Formulation and evaluation of chitosan/polyethylene oxide nanofibers loaded with metronidazole for local infections

Zupančič, Špela; Potrč, Tanja; Baumgartner, Stephan; Kocbek, Petra; Kristl, Julijana

doi:10.1016/j.ejps.2016.10.030

Cited by 47 publications

(27 citation statements)

References 37 publications

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“…For example, ciprofloxacin, a hydrophilic antibiotic drug for wound healing, showed burst release behavior in 2 min when incorporated into a water-soluble polymer [ 81 ] whereas sustained release of the same drug was reported up to 10 days (80% cumulative) when using a hydrophobic polymer [ 82 ]. Similar release behaviors with respect to the polymer used for small molecule hydrophilic antibiotics such as ampicillin [ 83 , 84 , 85 ], metronidazole [ 86 , 87 , 88 ], and cefazolin [ 89 , 90 ] were reported by others. In addition, drug loading in the polymer matrix plays an important role in the release mechanism of small molecule drugs from fibers.…”

Section: Release Of Small Molecule Drugssupporting

confidence: 74%

Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications

et al. 2018

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Wound healing is a complex tissue regeneration process that promotes the growth of new tissue to provide the body with the necessary barrier from the outside environment. In the class of non-healing wounds, diabetic wounds, and ulcers, dressing materials that are available clinically (e.g., gels and creams) have demonstrated only a slow improvement with current available technologies. Among all available current technologies, electrospun fibers exhibit several characteristics that may provide novel replacement dressing materials for the above-mentioned wounds. Therefore, in this review, we focus on recent achievements in electrospun drug-eluting fibers for wound healing applications. In particular, we review drug release, including small molecule drugs, proteins and peptides, and gene vectors from electrospun fibers with respect to wound healing. Furthermore, we provide an overview on multifunctional dressing materials based on electrospun fibers, including those that are capable of achieving wound debridement and wound healing simultaneously as well as multi-drugs loading/types suitable for various stages of the healing process. Our review provides important and sufficient information to inform the field in development of fiber-based dressing materials for clinical treatment of non-healing wounds.

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Section: Release Of Small Molecule Drugssupporting

confidence: 74%

Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications

et al. 2018

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“…Metronidazole is an antimicrobial with a high potential for local administration against anaerobic bacteria and protozoa pathogens [38]; its importance in the local treatment of vaginal infections is decades long and remains attractive.…”

Section: Resultsmentioning

confidence: 99%

Chitosan-Based Nanomedicine to Fight Genital Candida Infections: Chitosomes

et al. 2017

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Vaginal infections are associated with high recurrence, which is often due to a lack of efficient treatment of complex vaginal infections comprised of several types of pathogens, especially fungi and bacteria. Chitosan, a mucoadhesive polymer with known antifungal effect, could offer a great improvement in vaginal therapy; the chitosan-based nanosystem could both provide antifungal effects and simultaneously deliver antibacterial drugs. We prepared chitosan-containing liposomes, chitosomes, where chitosan is both embedded in liposomes and surface-available as a coating layer. For antimicrobial activity, we entrapped metronidazole as a model drug. To prove that mucoadhesivness alone is not sufficient for successful delivery, we used Carbopol-containing liposomes as a control. All vesicles were characterized for their size, zeta potential, entrapment efficiency, and in vitro drug release. Chitosan-containing liposomes were able to assure the prolonged release of metronidazole. Their antifungal activity was evaluated in a C. albicans model; chitosan-containing liposomes exhibited a potent ability to inhibit the growth of C. albicans. The presence of chitosan was crucial for the system’s antifungal activity. The antifungal efficacy of chitosomes combined with antibacterial potential of the entrapped metronidazole could offer improved efficacy in the treatment of mixed/complex vaginal infections.

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“…When tetracycline was incorporated into the core‐shell of the nanofibers, the drug was released over a period of 75 days, with a burst release of 19% within the first 2 hours. Using the electrospinning technique, Zupančič et al developed biocompatible and biodegradable chitosan/polyethylene oxide nanofibers with metronidazole as the active agent. The nanofibers swelled, eroded, and gradually released the metronidazole.…”

Section: Fibers As Delivery Systemsmentioning

confidence: 99%

Sustained‐release delivery of antimicrobial drugs for the treatment of periodontal diseases: Fantasy or already reality?

Steinberg

Friedman

2020

Periodontology 2000

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Periodontal diseases are prevalent in humans. Conventional means of combating these diseases involve basic oral hygiene, mostly toothbrushing, use of mouthwashes, and flossing. Supplementary means of treatment, either clinical or pharmaceutical, are often necessary. The use of sustained‐release delivery systems, applied locally to the periodontal pocket, seems to be one feasible approach: local sustained‐release delivery of antibacterial agents to treat periodontal diseases is conceivable. The use of local (intrapocket) sustained‐release delivery systems has numerous clinical, pharmacologic, and toxicologic advantages over conventional treatments for periodontal diseases. Sustained‐release technology has been proven to be effective over the last few decades. Films, gels, and fibers are the three main classical intrapocket pharmaceutical delivery systems. Research today is more focused on improving drug delivery, and less on introducing new drugs. New approaches, eg, those making use of nanotechnology, are emerging for local drug‐delivery systems. The local sustained‐release delivery system concept is innovative and a few products are already commercially available.

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Formulation and evaluation of chitosan/polyethylene oxide nanofibers loaded with metronidazole for local infections

Cited by 47 publications

References 37 publications

Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications

Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications

Chitosan-Based Nanomedicine to Fight Genital Candida Infections: Chitosomes

Sustained‐release delivery of antimicrobial drugs for the treatment of periodontal diseases: Fantasy or already reality?

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