2012
DOI: 10.3233/jad-2011-110506 View full text |Buy / Rent full text
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Abstract: Formononetin, an active constituent of the Chinese herb Astragali Radix, has been reported to have beneficial effects for Alzheimer's disease (AD). Yet the mechanism of this effect remains to be elucidated. The present study shows that formononetin increases soluble-AβPPα (sAβPPα) secretion and thus protects human-AβPP Swedish mutation cell (N2a-AβPP cell) from hypoxia-induced apoptosis. Using hypoxic N2a-AβPP cell as an in vitro model of AD-like pathology, we confirmed that regular treatment with formononetin… Show more

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“…Isoflavones, including FMNT, have been reported to protect hippocampal and cortical neurons from oxidative stress and toxic insult (Occhiuto et al ., ; Sonee et al ., ). In addition, FMNT can protect neurons against hypoxia‐induced apoptosis (Sun et al ., ) and prevent lipopolysaccharide‐induced injury in dopaminergic neurons (Chen et al ., ). In present study, we found that FMNT mainly prevented the cell loss and the early phase apoptosis induced by NMDA exposure.…”
Section: Discussionmentioning
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“…Isoflavones, including FMNT, have been reported to protect hippocampal and cortical neurons from oxidative stress and toxic insult (Occhiuto et al ., ; Sonee et al ., ). In addition, FMNT can protect neurons against hypoxia‐induced apoptosis (Sun et al ., ) and prevent lipopolysaccharide‐induced injury in dopaminergic neurons (Chen et al ., ). In present study, we found that FMNT mainly prevented the cell loss and the early phase apoptosis induced by NMDA exposure.…”
Section: Discussionmentioning
“…In recent decades, ginseng was also introduced to western countries where it became a popular medicine (Helms, 2004). Ginseng was reported to have several pharmacological functions (Buettner et al, 2006;Sun et al, 2012), and isolated and purified forms of the major components and effective functional molecule in ginseng root, ginsenosides, are now attracting increasing research interest (Cheng et al, 2005). Of particular current interest are investigations aimed at determining the detailed mechanisms underlying the action of ginsenosides, which would help to clarify the discrepancies found in previous literature.…”
Section: Introductionmentioning
“…Although the pathophysiology of IBS is not fully understood, several mechanisms have been proposed, such as altered intestinal motility, visceral sensitivity, alterations in the two-way communication between the brain and gut, stress, and psychological factors (Arrieta et al, 2006;Aerssens et al, 2008;Sun et al, 2012). Recent studies have suggested immune system dysfunction as an important fundamental factor underlying the risk factors of IBS occurrence (Bertiaux-Vandaële et al, 2011).…”
Section: The Rome III Criteria Classify the Ibs Phenotype Into 4 Grmentioning