Formation of nitri- and nitrosylhemoglobin in systems modeling the Maillard reaction

Kosmachevskaya, O. V.; Шумаев, К. Б.; Nasybullina, E. I.; Топунов, А. Ф.

doi:10.1515/cclm-2012-0792

Cited by 12 publications

(6 citation statements)

References 44 publications

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“…•− ) released during Hb auto-oxidation [34]. These reactive compounds can interact with each other, and with SH groups, heme, and non-heme iron, which leads to shifts in the thioldisulfide equilibrium and in Hb state [41,161]. Free iron ions and the ones included in heme and non-heme complexes play an important role in the coupling of glycation and ROS formation processes [162].…”

Section: Relationship Of Carbonyl Stress With Oxidative and Nitrosatimentioning

confidence: 99%

“…•− and NO. We have previously investigated the effect of the NO donors on the non-enzymatic Hb modification with MG [41,161]. It was found that S-nitrosoglutathione (GSNO) increased the formation of radical intermediates of the lysine reaction with MG, which lead to Hb reduction and nitrosylation.…”

Section: Relationship Of Carbonyl Stress With Oxidative and Nitrosatimentioning

confidence: 99%

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Carbonyl Stress in Red Blood Cells and Hemoglobin

2021

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The paper overviews the peculiarities of carbonyl stress in nucleus-free mammal red blood cells (RBCs). Some functional features of RBCs make them exceptionally susceptible to reactive carbonyl compounds (RCC) from both blood plasma and the intracellular environment. In the first case, these compounds arise from the increased concentrations of glucose or ketone bodies in blood plasma, and in the second—from a misbalance in the glycolysis regulation. RBCs are normally exposed to RCC—methylglyoxal (MG), triglycerides—in blood plasma of diabetes patients. MG modifies lipoproteins and membrane proteins of RBCs and endothelial cells both on its own and with reactive oxygen species (ROS). Together, these phenomena may lead to arterial hypertension, atherosclerosis, hemolytic anemia, vascular occlusion, local ischemia, and hypercoagulation phenotype formation. ROS, reactive nitrogen species (RNS), and RCC might also damage hemoglobin (Hb), the most common protein in the RBC cytoplasm. It was Hb with which non-enzymatic glycation was first shown in living systems under physiological conditions. Glycated HbA1c is used as a very reliable and useful diagnostic marker. Studying the impacts of MG, ROS, and RNS on the physiological state of RBCs and Hb is of undisputed importance for basic and applied science.

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Section: Relationship Of Carbonyl Stress With Oxidative and Nitrosatimentioning

confidence: 99%

Section: Relationship Of Carbonyl Stress With Oxidative and Nitrosatimentioning

confidence: 99%

Carbonyl Stress in Red Blood Cells and Hemoglobin

2021

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“…According to the pertinent literature on the subject, α-oxoaldehyde such as methylglyoxal plays an important role in the non-enzymatic and enzymatic production of free radicals in biological systems [5,17,20,[30][31][32]. For example, the free radical derivatives can be formed in the reaction of methylglyoxal -induced protein glycation [18].…”

Section: Formation Of Superoxide and Organic Free Radicals In The Reamentioning

confidence: 99%

Non-Enzymatic Methylglyoxal Formation From glucose Metabolites and Generation of Superoxide Anion Radical During Methylglyoxal-Dependent Cross-Links Reaction

Ланкин

Шадыро

Шумаев

et al. 2019

JAA

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The paper explores the formation of a-oxoaldehydes during the interaction of glucose metabolites with hydroxyl or alkoxyl radicals. Hydroxyl radicals were generated under radiolysis of aqueous solutions, and alkoxyl radicals (t-BuO · ) were obtained in the model system tert-butyl hydroperoxide/Fe 2+ . High-performance liquid chromatography revealed that methylglyoxal was one of the organic products resulting from t-BuO · -induced transformations of fructose-1,6-bisphosphate under hypoxic conditions. The interaction of lysine and methylglyoxal one of the main targets of a-oxoaldehydes in proteins was also studied. As chemiluminescence and EPR spectroscopy demonstrated, this reaction generates a methylglyoxal anion radical, a cation-radical of methylglyoxal dialkylamine and a superoxide anion radical. EPR signal of methylglyoxal-derived free radicals was observed in hypoxia, whereas only the trace amounts of these free radicals were recorded in the aerated reaction medium.

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“…Leghemoglobin is glycosylating as other hemoglobins [54]. Thus, another way for nitrosyl Lb to be formed in nodules could be the joint action of reactive nitrogen species and reactive carbonyl compounds (simultaneous display of nitrosative and carbonyl stress) similar to the case of mammalian Hb [55,56]. ROS and RNS could be formed in legume nodules under various negative factors, whereas different kinds of stress have similar affect [57,58].…”

Section: Dinitrosyl Iron Complexes and Plant Hemoglobinsmentioning

confidence: 99%

Dinitrosyl Iron Complexes and other Physiological Metabolites of Nitric Oxide: Multifarious Role in Plants

Шумаев

Kosmachevskaya

Чумикина

et al. 2016

Natural Product Communications

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This review considers dinitrosyl iron complexes (DNICs) and some other metabolites of nitric oxide (NO) in plants. Nitric oxide is vital for all living organisms, although its role in plants has been studied insufficiently compared with that in animals. We presume that the spectrum of its functions in plants is even wider than in animals. The main NO metabolites could be S-nitrosothiols, DNICs and peroxynitrite. Of particular interest are pro-and antioxidant properties of these compounds. DNICs function and their potential biosynthetic role in plants are practically unknown and brought to the limelight in this review. Since the process of NO biosynthesis in plants is still under discussion, we also specially examine this problem.

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Formation of nitri- and nitrosylhemoglobin in systems modeling the Maillard reaction

Cited by 12 publications

References 44 publications

Carbonyl Stress in Red Blood Cells and Hemoglobin

Carbonyl Stress in Red Blood Cells and Hemoglobin

Non-Enzymatic Methylglyoxal Formation From glucose Metabolites and Generation of Superoxide Anion Radical During Methylglyoxal-Dependent Cross-Links Reaction

Dinitrosyl Iron Complexes and other Physiological Metabolites of Nitric Oxide: Multifarious Role in Plants

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