Formation of Multicellular Aggregates of Adult Rat Hepatocytes

Sakai, Yasuyuki; Suzuki, Motoyuki

doi:10.1007/978-94-011-3550-4_15

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1992

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Cited by 4 publications

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“…In recent years, adult rat hepatocytes inoculated on some surfaces were reported to form spheroidal aggregates (spheroids), and they expressed higher liver-specific functions in longer term as compared to conventional monolayer cultures (Landry et al, 1985;Koide et al, 1989;Koide et al, 1990;Sakai and Suzuki, 1991a;Sakai and Suzuki, 1991b). In recent years, adult rat hepatocytes inoculated on some surfaces were reported to form spheroidal aggregates (spheroids), and they expressed higher liver-specific functions in longer term as compared to conventional monolayer cultures (Landry et al, 1985;Koide et al, 1989;Koide et al, 1990;Sakai and Suzuki, 1991a;Sakai and Suzuki, 1991b).…”

Section: Introductionmentioning

confidence: 99%

Immobilization and long-term albumin secretion of hepatocyte spheroids rapidly formed by rotational tissue culture methods

1992

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Spheroidal aggregates (spheroids) of adult rat hepatocytes in primary culture formed by rotational tissue culture methods. The time suitable for terminating the rotation and reseeding was determined. The spheroids formed were immobilized stably onto polylysine-coated surfaces, and they secreted albumin for about 2 weeks at almost the same level as compared to spheroids formed by stationary culture.

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