2017
DOI: 10.1021/acs.jafc.7b03938
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Abstract: Adducts of 5-hydroxymethylfurfural (HMF)-amino acids are formed during food processing and digestion; the elimination capacity of in vitro intestinal digests of biscuits, instant noodles, and potato crisps for HMF is 652, 727, and 540 μg/g, respectively. However, the safety of these adducts is unknown. In this study, an HMF-cysteine adduct named 1-dicysteinethioacetal-5-hydroxymehtylfurfural (DCH), which was found to be produced in the gastrointestinal tract after HMF intake, was prepared to test its effect to… Show more

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Cited by 23 publications
(32 citation statements)
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“…A previous study conducted by Zhao Q [ 39 ] reported that HMF expressed significant injury to Caco-2 cells, and the cell viability decreased with an increase in the concentration of HMF. However, the cell type and the concentration of HMF and DCH were different from ours.…”
Section: Resultsmentioning
confidence: 99%
“…A previous study conducted by Zhao Q [ 39 ] reported that HMF expressed significant injury to Caco-2 cells, and the cell viability decreased with an increase in the concentration of HMF. However, the cell type and the concentration of HMF and DCH were different from ours.…”
Section: Resultsmentioning
confidence: 99%
“…Cell viability was measured by the CCK-8 method as described by Zhao et al ( 31 ) with modifications. Briefly, Caco-2 cells at a density of 2.5 × 10 4 cells/well were seeded into 96-well plates and maintained at 37°C under a humidified atmosphere containing 5% CO 2 and 95% air for 24 h. Subsequently, the origin culture medium was removed, and different concentrations (2, 4, 8, 16, 32, and 64 mM) of HMZ and HMF were added.…”
Section: Methodsmentioning
confidence: 99%
“…[123] Ou prepared dithioacetal 110 by the reaction of HMF and cysteine in order to evaluate its cytotoxicity because this dithioacetal could be formed during food processing and digestion. [124] Scheme 42. Thioacetalization of 5-HMF…”
Section: Scheme 41 the Acetalization Of Hmf And Its Derivative With mentioning
confidence: 99%