Formaldehyde, acrolein and other carbonyls in dwellings of university students. Levels and source characterization

Villanueva, Florentina; Lara, Sonia; Notario, Alberto; Amo-Salas, Mariano; Cabañas, Beatriz

doi:10.1016/j.chemosphere.2021.132429

Cited by 10 publications

(4 citation statements)

References 48 publications

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“…Each factor from the PCA was associated with source characterization by its most representative CCs. Prior to statistical analysis, values below the limit of detection were substituted by LOD/2 to estimate means and standard deviations [35]. Multiple linear regression analysis was performed using a stepwise procedure with a 2…”

Section: Analytical Methodmentioning

confidence: 99%

Molecular Characteristics, Sources, and Health Risk Assessment of Gaseous Carbonyl Compounds in Residential Indoor and Outdoor Environments in a Megacity of Northwest China

Dai

Shen

et al. 2023

Indoor Air

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Carbonyl compounds (CCs) in indoor air pose a significant threat to residents’ health and have garnered considerable attention in recent years. However, most studies have focused on low-molecular-weight carbonyl compounds (LMW-CCs) and have underestimated the impact of high-molecular-weight ones (HMW-CCs), causing a failure to comprehensively understand their effects on health. In this study, we analyzed twenty carbonyls in the indoor and outdoor air at typical residential communities in a megacity in Northwest China by using high-performance liquid chromatography (HPLC) coupled with a photodiode array detector (DAD). The total concentration of indoor carbonyls was 1.4-3.4 times that of outdoor carbonyls. In addition, the concentration of indoor carbonyls was much higher during the heating season than that during the nonheating season. Conversely, the concentration of outdoor carbonyls was higher during the nonheating season than that during the heating season. The principal component analysis (PCA) revealed that indoor carbonyl pollution was primarily influenced by building materials, cooking fume, and wooden furniture. Formaldehyde exposure in indoor environments posed a greater health risk to children than acetaldehyde exposure. HMW-CCs were the primary contributors to indoor odor pollution, which was considered a significant cause of sick building syndrome (SBS). Our findings underscore the crucial role of HMW-CCs in indoor environments in exerting adverse impacts on health.

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Section: Analytical Methodmentioning

confidence: 99%

Molecular Characteristics, Sources, and Health Risk Assessment of Gaseous Carbonyl Compounds in Residential Indoor and Outdoor Environments in a Megacity of Northwest China

Dai

Shen

et al. 2023

Indoor Air

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“…Acrolein is a bis-electrophilic α,β-unsaturated carbonyl volatile organic compound with sky-high reactivity that ubiquitously exists in the environment from manifold natural and anthropogenic sources, such as wildfire, combustion of organic materials (wood, fuel, paper, incense, candle, etc. ), overheated cooking of food and oil, cigarette smoke, biocide utilization, furniture emission, and industry/automobile exhaust. − Collectively, people in daily life are widely exposed to substantial acrolein via inhalation, in contact with skin, and ingestion. − …”

Section: Introductionmentioning

confidence: 99%

Acrolein Exposure Impaired Glucose Homeostasis and Increased Risk of Type 2 Diabetes: An Urban Adult Population-Based Cohort Study with Repeated Measures

Wang

Liu

et al. 2023

Environ. Sci. Technol.

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Acrolein is an identified high-priority hazardous air pollutant ubiquitous in daily life and associated with cardiometabolic risk that attracts worldwide attention. However, the etiology role of acrolein exposure in glucose dyshomeostasis and type 2 diabetes (T2D) is unclear. This repeated-measurement prospective cohort study included 3522 urban adults. Urine/blood samples were repeatedly collected for determinations of acrolein metabolites (N-acetyl-S-(3-hydroxypropyl)-L-cysteine, N-acetyl-S-(2-carboxyethyl)-L-cysteine; acrolein exposure biomarkers), glucose homeostasis, and T2D at baseline and a three-year follow-up. We found that each 3-fold increment in acrolein metabolites was cross-sectionally associated with 5.91−6.52% decrement in homeostasis model assessmentinsulin sensitivity (HOMA-IS) and 0.07−0.14 mmol/L, 4.02−4.57, 5.91− 6.52, 19−20, 18−19, and 23−31% increments in fasting glucose (FPG), fasting insulin (FPI), HOMA-insulin resistance (HOMA-IR), risks of prevalent IR, impaired fasting glucose (IFG), and T2D, respectively; longitudinally, participants with sustained-high acrolein metabolite levels had increased risks of incident IR, IFG, and T2D by 63−80, 87−99, and 120−154%, respectively (P < 0.05). In addition, biomarkers of heme oxygenase-1 activity (exhaled carbon monoxide), lipid peroxidation (8-iso-prostaglandin-F2α), protein carbonylation (protein carbonyls), and oxidative DNA damage (8-hydroxy-deoxyguanosine) mediated 5.00−38.96% of these associations. Our study revealed that acrolein exposure may impair glucose homeostasis and increase T2D risk via mediating mechanisms of heme oxygenase-1 activation, lipid peroxidation, protein carbonylation, and oxidative DNA damage.

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“…Ceramic industries can also emit Cl2 inlands (Galán et al, 2002). Saturated aldehydes, like formaldehyde, acetaldehyde, pentanal, and hexanal, are emitted into the atmosphere (Clarisse et al, 2003;Calvert et al, 2011;Villanueva et al, 2022) mainly from primary sources, e.g. natural gas from power stations, landfill gas, 35 flaring from offshore, and transport (Calvert et al, 2011).…”

mentioning

confidence: 99%

“…In this work, we focus on the atmospheric chemistry of 2-methylpentanal (2MP, CH3CH2CH2CH(CH3)C(O)H) and its consequences on air quality. This aldehyde can be released to the environment from some foods (Villanueva et al, 2022; 40 Clarisse et al, 2003;Calvert et al, 2011) and from contaminated water in waste streams (Bao et al, 1998), since it is widely used as a flavoring ingredient and as an intermediate in the synthesis of dyes, resins, and pharmaceuticals (Furia and Bellanca, 1975). Moreover, 2MP has been detected in ambient air at the foot of the Everest mountain (Ciccioli et al, 1993) and in certain indoor environments from emissions of the cigarette smoke (Xu et al, 2003;Lippmann, 2000).…”

mentioning

confidence: 99%

Atmospheric impact of 2-methylpentanal emissions: Kinetics, photochemistry, and formation of secondary pollutants

Asensio¹,

Blázquez²,

Antiñolo³

et al. 2023

Preprint

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Abstract. The tropospheric fate of 2-methylpentanal (2MP) has been investigated in this work. First, the photochemistry of 2MP under simulated solar conditions was investigated by determining the UV absorption cross sections (220–360 nm) and the effective photolysis quantum yield in the UV solar actinic region (λ > 290 nm). The photolysis rate coefficient in that region was estimated using a radiative transfer model. Photolysis products were identified by Fourier Transform Infrared (FTIR) spectroscopy. Secondly, a kinetic study of the Cl- and OH- reactions of 2MP was also performed at 298 K and as a function of temperature (263–353 K), respectively. For the Cl-reaction, a relative kinetic method was used in a smog chamber coupled to FTIR spectroscopy, whereas for the OH-reaction, the Pulsed Laser Photolysis with Laser Induced Fluorescence (PLP-LIF) technique was employed. The estimated lifetime of 2MP depends on the location, the season, and the time of the day. Under mild-strong irradiation conditions, UV photolysis of 2MP may compete with its OH-reaction in a global atmosphere, while Cl reaction dominates in coastal areas at dawn. Finally, the gaseous product distribution of the Cl- and OH-reactions was measured in a smog chamber as well as the formation of secondary organic aerosols (SOAs) in the Cl-reaction and its size distribution (diameter between 5.6 and 560 nm). The implications on air quality are discussed based on the observed products.

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Formaldehyde, acrolein and other carbonyls in dwellings of university students. Levels and source characterization

Cited by 10 publications

References 48 publications

Molecular Characteristics, Sources, and Health Risk Assessment of Gaseous Carbonyl Compounds in Residential Indoor and Outdoor Environments in a Megacity of Northwest China

Molecular Characteristics, Sources, and Health Risk Assessment of Gaseous Carbonyl Compounds in Residential Indoor and Outdoor Environments in a Megacity of Northwest China

Acrolein Exposure Impaired Glucose Homeostasis and Increased Risk of Type 2 Diabetes: An Urban Adult Population-Based Cohort Study with Repeated Measures

Atmospheric impact of 2-methylpentanal emissions: Kinetics, photochemistry, and formation of secondary pollutants

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