2010
DOI: 10.1083/jcb.200906139
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Abstract: Analysis of the relationship between actin network velocity and traction forces at the substrate shows that force transmission mechanisms vary with distinct regions of the cell.

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Cited by 208 publications
(208 citation statements)
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References 42 publications
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“…As indicated above, cell motion requires the transmission of the traction forces developed in actomyosin microfilaments to the substrate via focal adhesion complexes that connect actin microfilaments to the extracellular matrix (35). Experimental disruption of the generation of such intracellular forces impedes a range of functions, including directed cell migration.…”
Section: Resultsmentioning
confidence: 99%
“…As indicated above, cell motion requires the transmission of the traction forces developed in actomyosin microfilaments to the substrate via focal adhesion complexes that connect actin microfilaments to the extracellular matrix (35). Experimental disruption of the generation of such intracellular forces impedes a range of functions, including directed cell migration.…”
Section: Resultsmentioning
confidence: 99%
“…S3 A and B). Cell spreading is known to be mediated by actin treadmilling (36,37), which controls the extension of the lamellipodium (38). An effect of treadmilling is the net flow of filamentous actin from the lamellipodial region to the proximal part of the actomyosin cytoskeleton between adhesions (37, 39), which persists even if the cell and its adhesions are immobile (18).…”
Section: Resultsmentioning
confidence: 99%
“…A signicant progress has been recently made, especially for relatively simple cells like the well-studied keratocytes living on the skin of most sh and participating in its wound healing response. [10][11][12] However, a thorough understanding of the functioning and design concepts of cellular substrate-based selfpropelled motion has not yet been fully achieved. It is therefore an important challenge to design and control synthetic selfpropelled substrate-based objects and to support these efforts by efficient modeling approaches.…”
Section: Introductionmentioning
confidence: 99%