Foods and liver health

Morisco, Filomena; Vitaglione, Paola; Amoruso, Daniela Caterina; Russo, Barbara; Fogliano, Vincenzo; Caporaso, N.

doi:10.1016/j.mam.2007.09.003

Cited by 52 publications

(26 citation statements)

References 45 publications

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“…Foods rich in antioxidants have also been proposed as a tool to prevent liver damage (Morisco et al, 2008). It is generally assumed that these antioxidant compounds may scavenge free radicals and regulate the activity and/or expression of certain enzymatic systems implicated in relevant physiological processes like the metabolism of xenobiotics in the liver (Singletary and Rokusek, 1997;Subbaramaiah et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of Rosmarinus officinalis and rosmarinic acid on acetaminophen-induced liver damage

Lucarini

Bernardes

Tozatti

et al. 2014

Emir. J. Food Agric

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The hydroalcoholic extract of the leaves of Rosmarinus officinalis (HE), a species of medicinal value, and its constituent rosmarinic acid (RA) were evaluated for hepatoprotective in the acetaminophen-induced liver damage model. Groups of Wistar albino rats (n=6) were pre-administered with HE (100, 250 and 500 mg/kg, p.o.) and RA (10, 25 and 50 mg/kg, p.o.) prior to a single dose of acetaminophen (APAP, 600 mg/kg body weight; p.o). The hepatoprotective activity of HE extract was observed through histopathological analysis and reduction of the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP). These observations were comparable to the normal group prior to APAP administration. Group that was treated with APAP alone exhibited high levels of transaminases and ALP. The obtained results from the present study suggested that HE may prevent APAP-induced hepatic injuries. RA did not displayed significant hepatoprotective activity against APAP-induced liver damage.

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Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of Rosmarinus officinalis and rosmarinic acid on acetaminophen-induced liver damage

Lucarini

Bernardes

Tozatti

et al. 2014

Emir. J. Food Agric

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“…The study by Ding and Li (2007) provides preliminary data confirming the hepatoprotective effect of the crude ethanolic extract of Meconopsis quintuplinervia. Antioxidants extracted from plants play an important role in liver protection (Morisco et al, 2008;Akanitapichat et al, 2010;Huang et al, 2010). However, the antioxidant activity of Meconopsis quintuplinervia has not been reported yet.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo antioxidant activity of the ethanolic extract from Meconopsis quintuplinervia

Huang

Ban

et al. 2012

Journal of Ethnopharmacology

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“…This leads to different types of liver diseases. 27,28 These medicinal plants are always beneficial for mankind by resolving the health issues and various studies has been conducted on traditional medicine to develop new drug for antioxidant and hepatoprotective activity. 29 Ethanol extract of B.scandens has phytoconstituents like phenols flavonoids, tannins, alkaloids.…”

Section: Discussionmentioning

confidence: 99%

In vitro Antioxidant and Hepatoprotective Activity of Bridelia scandens (Roxb.)Willd

Jinadatta¹,

Rao²,

Rajshekarappa³

et al. 2017

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Natural products are emerging out as potent and alternative therapies for many diseases. Today herbs have become the part of mankind, because of its manifold ways in targeting diseased cells with minimal effects on normal cells and tissues. The present research investigated the in vitro antioxidant activity and hepatoprotective of B.scandens leaf. Preliminary phytochemical analysis exhibited the presence of most of the constituent in ethanol extract (BSE). Antioxidant capacity of various extracts of B.scandens was examined. DPPH assay revealed that ethanol extract has a good antioxidant with IC 50 value of 31.68µg/ml, whereas standard ascorbic acid with 8.78 µg/ml. BSE revealed dose dependent response with increase in concentration for reducing power assay. ORAC assay directly measured the scavenging capacity and BSE (2485 trolox eq/gm) was found to be potent than other extracts. In vitro hepatoprotective activity was performed for BSE using MTT assay in BRL 3A cell line, which revealed nontoxic dose with CTC 50 value more than 1000 µg/ml. At the dose 200 µg/ml, BSE and standard silymarin offered cell protection of 57% and 76 % respectively. Present study concludes that B.scandens leaf extract possess antioxidant potential and protect the liver cells against CCl 4 damage. However in vivo studies are being carried out to validate the traditional usage of Bridelia scandens.

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Foods and liver health

Cited by 52 publications

References 45 publications

Hepatoprotective effect of Rosmarinus officinalis and rosmarinic acid on acetaminophen-induced liver damage

Hepatoprotective effect of Rosmarinus officinalis and rosmarinic acid on acetaminophen-induced liver damage

In vitro and in vivo antioxidant activity of the ethanolic extract from Meconopsis quintuplinervia

In vitro Antioxidant and Hepatoprotective Activity of Bridelia scandens (Roxb.)Willd

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