Food selection based on total antioxidant capacity can modify antioxidant intake, systemic inflammation, and liver function without altering markers of oxidative stress

Valtueña, Silvia; Pellegrini, Nicoletta; Franzini, Laura; Bianchi, Marta; Ardigò, Diego; Rio, Daniele Del; Piatti, PierMarco; Scazzina, Francesca; Zavaroni, Ivana; Brighenti, Furio

doi:10.1093/ajcn/87.5.1290

Cited by 149 publications

(118 citation statements)

References 50 publications

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

Section: Discussionmentioning

confidence: 92%

“…Valtueña et al (2008) found that the total antioxidant capacity of food correlated with the liver function whereas plasma total antioxidant capacity did not change. Hepatic inflammation seems to contribute to the low-grade systemic inflammation associated with the metabolic syndrome (Valtueña et al, 2008). In our study, the plasma antioxidant capacity measured as ORAC did not change statistically significantly in either group, although there was an increasing trend, and the trend was stronger in the berry group.…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Berry meals and risk factors associated with metabolic syndrome

et al. 2010

View full text Add to dashboard Cite

Background/Objectives: Nonalcoholic fatty liver disease is commonly associated with obesity, insulin resistance, dyslipidemia and type 2 diabetes, and can thus be regarded as the hepatic manifestation of metabolic syndrome. In this study we compared the effects of lifestyle intervention with and without industrial berry products, on risk factors associated with metabolic syndrome on slightly overweight women. Subjects/Methods: Sixty-one female volunteers (average age 42.9 years) were recruited and randomized for a 20-week dietary intervention trial with two parallel treatment groups, one lifestyle intervention group with berry products equaling with an average daily dose of 163 g of northern berries (berry group, diet 1, N ¼ 31, of which 28 completed the study) and the other group with lifestyle intervention only (control group, diet 2, N ¼ 30, of which 22 completed the study). Results: Increased berry consumption as part of the normal daily diet was the only lifestyle difference between the two intervention groups. The major effects achieved by diet 1 were changes in the levels of alanine aminotransferase (ALAT) and adiponectin (at P-values o0.001 and 0.002, respectively). A statistically significant difference between the two intervention groups was the higher decrease in the ALAT value in the berry group (P ¼ 0.003). Conclusions: The 23% decrease in the ALAT value, from 20.29 to 15.66 U/l in the berry group may be regarded as nutritionally significant by enhancing the liver function. This may contribute positively to the low-grade systemic inflammation in body and decrease the risk of cardiovascular diseases.

show abstract

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 92%

Berry meals and risk factors associated with metabolic syndrome

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Nutrient data for specific foods were obtained from the food composition database for epidemiological studies in Italy (Salvini et al, 1998) integrated with the TAC values of a number of foods representative of the average Italian diet, such as fruits, vegetables, oils, beverages, spices, dried fruits, sweets, cereals, pulses and nuts (Pellegrini et al, 2003(Pellegrini et al, , 2006. The TAC database has been widely validated in the Italian population (Brighenti et al, 2005;Valtueña et al, 2008;Del Rio et al, 2011) as well in Spanish (Agudo et al, 2007) and Greek populations (Detopoulou et al, 2010;Psaltopoulou et al, 2011).…”

Section: Study Subjectsmentioning

confidence: 99%

Total dietary antioxidant capacity and lung function in an Italian population: a favorable role in premenopausal/never smoker women

et al. 2011

View full text Add to dashboard Cite

Background/Objectives: Antioxidant-rich foods may favorably influence lung function. We examined possible associations between the total dietary antioxidant capacity (TAC) and pulmonary function in a healthy Italian population. Subjects/Methods: Until May 2009, 22 300 persons were randomly recruited from the general population in the Moli-sani project. A sample only including healthy women (5824) and men (5848) was analyzed. TAC was measured in foods by three different assays and the ferric reducing-antioxidant power (FRAP) assay was selected as the better indicator of dietary TAC. The European Investigation into Cancer and Nutrition Food Frequency Questionnaire was used for dietary assessment. The association between quintiles of dietary FRAP and pulmonary indexes was assessed using analysis of variance separately for men and women. Results: After adjustment for confounders, women in the highest quintile of FRAP intake had þ 39 ml forced expiratory volume in the first second (FEV 1 ) and þ 54 ml forced vital capacity, compared with those in the lowest quintile (P for trend p0.006). Stratified analysis showed that this relationship only occurred in women who were premenopausal/never smokers. In this subgroup, the observed effect of higher FRAP intake on FEV 1 was equivalent to an improvement in pulmonary age of 3.3 years. In men, all significant associations between pulmonary function and TAC were lost after adjustment for confounding. Conclusions: Dietary TAC may have a favorable role in respiratory health, particularly in premenopausal/never smoker women.

show abstract

“…A total of 34 healthy adults were recruited among a population of workers and former workers of a food company in the Parma area, as described elsewhere (Valtueña et al, 2008). Exclusion criteria were diabetes mellitus, cardiovascular events, evidence of hepatitis B virus or hepatitis C virus infection, chronic liver diseases or nephropathies, cancer, organ failure, smoking, last menses within the past 12 months, taking cholesterol-lowering or antiinflammatory medications, and having taken hormone replacement therapy for the past 12 months.…”

Section: Participantsmentioning

confidence: 99%

“…The study was originally designed with the primary objective of investigating the effects of low and high-antioxidant diets on systemic inflammation and liver dysfunction, as previously reported (Valtueña et al, 2008), and also to assess whether dietary TAC could influence plasma concentrations of b-carotene while controlling for other dietary factors known to affect b-carotene concentrations, including its own intake. Briefly, participants were asked to follow a high-TAC diet (HT) and a low-TAC diet (LT) for 14 days each, with a 14-day washout period (WO) in between.…”

Section: Study Design and Sample Collectionmentioning

confidence: 99%

Intervention study with a high or low antioxidant capacity diet: effects on circulating β-carotene

et al. 2009

View full text Add to dashboard Cite

Background and objectives: A cross-sectional observation suggests that total antioxidant capacity (TAC) of the diet positively affects plasma concentrations of b-carotene independent of b-carotene intake. This study was carried out to investigate the effect of two dietary strategies, designed to be comparable in fruits, vegetables, fibre, alcohol and b-carotene intake but substantially different in their TAC, on changes in antioxidant intake and antioxidant status, and in particular in circulating b-carotene concentrations. Subjects: A randomized cross-over intervention trial involving 33 healthy participants and consisting of two 14-day dietary periods (high TAC diet, HT; low TAC diet, LT) with a 14-day washout in between was conducted. Results: Energy, macronutrient, dietary fibre, alcohol and b-carotene intake was not significantly different between LT and HT, whereas intake of other carotenoids and dietary TAC was significantly higher in the HT than in the LT (Po0.001). Circulating carotenoids (with the exception of a-carotene, which followed an inverse trend) and a-tocopherol decreased significantly during the LT and increased during the HT period. Among these, b-carotene almost doubled its concentration in plasma after the HT diet. Conclusions: The increase in circulating b-carotene along with the increase in dietary TAC suggests that plasma b-carotene could be a marker of TAC intake rather than of b-carotene intake itself. This may explain, in part, why b-carotene supplementation alone has shown no benefit in chronic disease prevention and adds to a putative beneficial role of high dietary TAC diets, which merits further investigation.

show abstract

Food selection based on total antioxidant capacity can modify antioxidant intake, systemic inflammation, and liver function without altering markers of oxidative stress

Abstract: Selecting foods according to their TAC markedly affects antioxidant intake and modulates hepatic contribution to systemic inflammation without affecting traditional markers of antioxidant status.

Cited by 149 publications

References 50 publications

Berry meals and risk factors associated with metabolic syndrome

Berry meals and risk factors associated with metabolic syndrome

Total dietary antioxidant capacity and lung function in an Italian population: a favorable role in premenopausal/never smoker women

Intervention study with a high or low antioxidant capacity diet: effects on circulating β-carotene

Contact Info

Product

Resources

About