Food matrix and co-presence of turmeric compounds influence bioavailability of curcumin in healthy humans

Nasef, Noha Ahmed; Loveday, Simon M.; Golding, Matthew; Martins, Ralph N.; Shah, Tejal; Clarke, Michael; Coad, Jane; Moughan, Paul J.; Garg, Manohar L.; Singh, Harjinder

doi:10.1039/c9fo01063g

Cited by 23 publications

(20 citation statements)

References 33 publications

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“…Some recent papers have also showed the importance of food matrix in curcumin absorption [71,72], highlighting an enhanced bioavailability when it is consumed as fresh or powdered turmeric with respect to supplements, which could be due to the synergic activity with other turmeric compounds and/or to a turmeric matrix effect [71].…”

Section: Curcumin: Metabolism and Bioavailabilitymentioning

confidence: 99%

Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin

2020

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Curcumin, a lipophilic polyphenol contained in the rhizome of Curcuma longa (turmeric), has been used for centuries in traditional Asian medicine, and nowadays it is widely used in food as dietary spice worldwide. It has received considerable attention for its pharmacological activities, which appear to act primarily through anti-inflammatory and antioxidant mechanisms. For this reason, it has been proposed as a tool for the management of many diseases, among which are gastrointestinal and neurological diseases, diabetes, and several types of cancer. However, the pharmacology of curcumin remains to be elucidated; indeed, a discrepancy exists between the well-documented in vitro and in vivo activities of curcumin and its poor bioavailability and chemical instability that should limit any therapeutic effect. Recently, it has been hypothesized that curcumin could exert direct regulative effects primarily in the gastrointestinal tract, where high concentrations of this polyphenol have been detected after oral administration. Consequently, it might be hypothesized that curcumin directly exerts its regulatory effects on the gut microbiota, thus explaining the paradox between its low systemic bioavailability and its wide pharmacological activities. It is well known that the microbiota has several important roles in human physiology, and its composition can be influenced by a multitude of environmental and lifestyle factors. Accordingly, any perturbations in gut microbiome profile or dysbiosis can have a key role in human disease progression. Interestingly, curcumin and its metabolites have been shown to influence the microbiota. It is worth noting that from the interaction between curcumin and microbiota two different phenomena arise: the regulation of intestinal microflora by curcumin and the biotransformation of curcumin by gut microbiota, both of them potentially crucial for curcumin activity. This review summarizes the most recent studies on this topic, highlighting the strong connection between curcumin and gut microbiota, with the final aim of adding new insight into the potential mechanisms by which curcumin exerts its effects.

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Section: Curcumin: Metabolism and Bioavailabilitymentioning

confidence: 99%

Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin

2020

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“…The literature is controversial about the use of dTAC, since the bioavailability of antioxidants in the diet is not yet known [ 15 ]. However, recent studies suggest that there is a synergistic effect between the food components released by the digestion process that enhances antioxidant compound bioaccessibility and absorption [ 59 – 62 ]. These components may act as carriers of antioxidant compounds, through the gastrointestinal tract, protecting them from oxidative reactions and maintaining their stability [ 59 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

Baseline Diet Quality Is Related to Changes in the Body Composition and Inflammatory Markers: An Intervention Study Based on Resistance Training and Nutritional Advice

Coelho

Lopes

Oliveira

et al. 2021

BioMed Research International

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Habitual food intake and physical activity can affect chronic low-grade inflammation, which is common in the elderly, because of changes in the immune system and body composition. Thus, the present study proposes an evaluation of the influence of past eating habits on the effects of an intervention of resistance training plus dietary advice on the inflammatory profile of the elderly. We conducted an intervention study with 40 elderly people. The Revised Diet Quality Index (HEI-R) and the dietary total antioxidant capacity (dTAC) were calculated before the intervention based on a food frequency questionnaire validated to the elderly population. Participants were categorized according to the median of HEI-R and dTAC to assess the influence of the habitual diet quality on anthropometry and inflammatory markers (CRP, IL-8, CCL-2, and leptin) before and after the intervention. The 19-week intervention provided a long-term progressive resistance training associated with dietary advice focused on foods rich in compounds with anti-inflammatory and antioxidant properties. There was a greater reduction in weight, body mass index (BMI), and body fat (%) in the group with the lowest HEI-R and a greater reduction in the body fat (%) in the group with the lowest dTAC, indicating that the group that had a worse diet quality before the intervention responded better to it. The index HEI-R correlated negatively with Δ weight and Δ BMI. dTAC correlated positively with Δ monocyte 1 chemotactic protein (CCL-2) and Δ C-reactive protein (CRP). In this scenario, elderly persons with bad habits can benefit from interventions to lifestyle change, while the better diet quality including dietary antioxidant sources can be useful to control weight and inflammatory biomarkers in this population.

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“…The formulation was obtained by combining the hydrophobic and hydrophilic compoundsthe three major curcuminoids, once extracted, are combined with turmeric water-soluble constituents, such as dietary fiber, carbohydrates, proteins, and lipophilic turmeric essential oil [84,98]. The synergism that occurs within turmeric matrix constituents enhances curcumin bioavailability thanks to physical stability improvement, protection from degradation, controlled release of curcuminoids, and, consequently, higher absorbability [84,99]. Human bioavailability was assessed by a pilot crossover study involving 12 healthy males and the formulation resulted in a 5.5-fold AUC increase compared to unformulated powder [83].…”

Section: How To Improve Absorption Affecting Intestinal Uptakementioning

confidence: 99%

Improving Curcumin Bioavailability: Current Strategies and Future Perspectives

2021

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Curcumin possesses a plethora of interesting pharmacological effects. Unfortunately, it is also characterized by problematic drug delivery and scarce bioavailability, representing the main problem related to the use of this compound. Poor absorption, fast metabolism, and rapid systemic clearance are the most important factors contributing to low curcumin levels in plasma and tissues. Accordingly, to overcome these issues, numerous strategies have been proposed and are investigated in this article. Due to advances in the drug delivery field, we describe here the most promising strategies for increasing curcumin bioavailability, including the use of adjuvant, complexed/encapsulated curcumin, specific curcumin formulations, and curcumin nanoparticles. We analyze current strategies, already available in the market, and the most advanced technologies that can offer a future perspective for effective curcumin formulations. We focus the attention on the effectiveness of curcumin-based formulations in clinical trials, providing a comprehensive summary. Clinical trial results, employing various delivery methods for curcumin, showed that improved bioavailability corresponds to increased therapeutic efficacy. Furthermore, advances in the field of nanoparticles hold great promise for developing curcumin-based complexes as effective therapeutic agents. Summarizing, suitable delivery methods for this polyphenol will ensure the possibility of using curcumin-derived formulations in clinical practice as preventive and disease-modifying therapeutics.

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Food matrix and co-presence of turmeric compounds influence bioavailability of curcumin in healthy humans

Abstract: Turmeric enhances curcumin bioavailability in healthy men.

Cited by 23 publications

References 33 publications

Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin

Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin

Baseline Diet Quality Is Related to Changes in the Body Composition and Inflammatory Markers: An Intervention Study Based on Resistance Training and Nutritional Advice

Improving Curcumin Bioavailability: Current Strategies and Future Perspectives

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