Food groups and the likelihood of non-alcoholic fatty liver disease: a systematic review and meta-analysis

He, Kaiyin; Li, Yuting; Guo, Xin; Zhong, Lina; Tang, Shaohui

doi:10.1017/s0007114520000914

Cited by 73 publications

(67 citation statements)

References 74 publications

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“…Lastly, a more recent systematic review and meta-analysis ( n = 9887) that analysed the influence of all foods on NAFLD development found that dietary intake of added fructose specifically (in the form of sucrose or HFCS) was positively correlated with the likelihood of NAFLD (OR 1.29, CI 95% 0.19–1.40) [ 82 ]. It is not yet known if there is a safety threshold for SSB or sugary food consumption for NAFLD prevention [ 83 ].…”

Section: Nutrition and Nafldmentioning

confidence: 99%

Overview of Non-Alcoholic Fatty Liver Disease (NAFLD) and the Role of Sugary Food Consumption and Other Dietary Components in Its Development

2021

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NAFLD is the world’s most common chronic liver disease, and its increasing prevalence parallels the global rise in diabetes and obesity. It is characterised by fat accumulation in the liver evolving to non-alcoholic steatohepatitis (NASH), an inflammatory subtype that can lead to liver fibrosis and cirrhosis. Currently, there is no effective pharmacotherapeutic treatment for NAFLD. Treatment is therefore based on lifestyle modifications including changes to diet and exercise, although it is unclear what the most effective form of intervention is. The aim of this review, then, is to discuss the role of specific nutrients and the effects of different dietary interventions on NAFLD. It is well established that an unhealthy diet rich in calories, sugars, and saturated fats and low in polyunsaturated fatty acids, fibre, and micronutrients plays a critical role in the development and progression of this disease. However, few clinical trials have evaluated the effects of nutrition interventions on NAFLD. We, therefore, summarise what is currently known about the effects of macronutrients, foods, and dietary patterns on NAFLD prevention and treatment. Most current guidelines recommend low-calorie, plant-based diets, such as the Mediterranean diet, as the most effective dietary pattern to treat NAFLD. More clinical trials are required, however, to identify the best evidence-based dietary treatment approach.

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Section: Nutrition and Nafldmentioning

confidence: 99%

Overview of Non-Alcoholic Fatty Liver Disease (NAFLD) and the Role of Sugary Food Consumption and Other Dietary Components in Its Development

2021

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“…These eating habits are typically found in the Western pattern diet, which is highly related with the development of multiple metabolic diseases including NAFLD [ 13 , 14 , 15 ]. A recent meta-analysis indicated that consumption of red meat and soft drinks is related with an increased likelihood of NAFLD [ 16 ]. Likewise, high intake of red meat is associated with insulin resistance [ 15 ].…”

Section: Nutritional Management Of Nafldmentioning

confidence: 99%

Nutritional Approaches for the Management of Nonalcoholic Fatty Liver Disease: An Evidence-Based Review

2020

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Nonalcoholic fatty liver disease (NAFLD) is on the rise worldwide representing a public health issue. Its coexistence with obesity and other metabolic alterations is highly frequent. Therefore, current therapy interventions for NAFLD are mainly focused on progressive weight loss through modulation of overall calorie intake with or without specific macronutrient adjustments. Furthermore, other relevant nutritional interventions are built on food selection and time-restricted eating. Since every strategy might bring different results, choosing the optimal diet therapy for a patient is a complicated task, because NAFLD is a multifactorial complex disease. Importantly, some factors need to be considered, such as nutrition-based evidence in terms of hepatic morphophysiological improvements as well as adherence of the patient to the meal plan and adaptability in their cultural context. Thus, the purpose of this review is to explore and compare the subtleties and nuances of the most relevant clinical practice guidelines and the nutritional approaches for the management of NAFLD with a special attention to tangible outcomes and long-term adherence.

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“…However, despite clear documentation that dietary and exercise interventions are effective, many patients fail to adhere to the recommendations for different reasons [ 1 , 38 ]. A recent meta-analysis investigating the relationship between the risk for NAFLD in association with different food groups (e.g., vegetables, fruits, red meat, fish, refined grains, whole grains, soft drinks) found that red meat and soft drink intake is positively associated with NAFLD [ 39 ]. The impact of specific diets on NAFLD is now well documented, such as the differences in the effects of Westernized versus Mediterranean diets [ 1 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants

et al. 2020

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Non-alcoholic fatty liver disease (NAFLD) is often the hepatic expression of metabolic syndrome and its comorbidities that comprise, among others, obesity and insulin-resistance. NAFLD involves a large spectrum of clinical conditions. These range from steatosis, a benign liver disorder characterized by the accumulation of fat in hepatocytes, to non-alcoholic steatohepatitis (NASH), which is characterized by inflammation, hepatocyte damage, and liver fibrosis. NASH can further progress to cirrhosis and hepatocellular carcinoma. The etiology of NAFLD involves both genetic and environmental factors, including an unhealthy lifestyle. Of note, unhealthy eating is clearly associated with NAFLD development and progression to NASH. Both macronutrients (sugars, lipids, proteins) and micronutrients (vitamins, phytoingredients, antioxidants) affect NAFLD pathogenesis. Furthermore, some evidence indicates disruption of metabolic homeostasis by food contaminants, some of which are risk factor candidates in NAFLD. At the molecular level, several models have been proposed for the pathogenesis of NAFLD. Most importantly, oxidative stress and mitochondrial damage have been reported to be causative in NAFLD initiation and progression. The aim of this review is to provide an overview of the contribution of nutrients and food contaminants, especially pesticides, to oxidative stress and how they may influence NAFLD pathogenesis.

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Food groups and the likelihood of non-alcoholic fatty liver disease: a systematic review and meta-analysis

Cited by 73 publications

References 74 publications

Overview of Non-Alcoholic Fatty Liver Disease (NAFLD) and the Role of Sugary Food Consumption and Other Dietary Components in Its Development

Overview of Non-Alcoholic Fatty Liver Disease (NAFLD) and the Role of Sugary Food Consumption and Other Dietary Components in Its Development

Nutritional Approaches for the Management of Nonalcoholic Fatty Liver Disease: An Evidence-Based Review

Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants

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