Food for thought ... on the evolution of toxicology and phasing out of animal testing

Food for thought ... considerations and guidelines for basic test method descriptions in toxicology

“…Stimulation of discussion has always been a major intention of Altex, for instance in the food for thought articles (leist et al, 2008b;Hartung and Leist, 2008;Hartung, 2010aHartung, ,b, 2009Hartung, , 2008aHartung, ,b, 2007Bottini and Hartung, 2009;Rovida, 2010;Hartung and Koëter, 2008), in addition to the traditional provision of information on diverse topics related to animal welfare (Animal welfare perspective: Kolar and Rusche, 2008;Schmidt, 2008;Sauer, 2009b;Kamber, 2009Kamber, , eskes et al, 2009Stingl et al, 2009) and the teaching of 3R methods (Jukes, 2008(Jukes, , 2009Leist, 2006;Daneshian et al, 2010). ALtex has welcomed articles on test method validation Vogel, 2009;Hartung and Rovida, 2009), the regulatory context for such methods and also on funding for such method development (Devolder, 2008).…”

Critical evaluation of the use of dogs in biomedical research and testing in Europe

“…Though this vision has no aspect specific to dog use, it has created a spirit of optimism that the replacement of currently conducted animal testing by mechanistically based higher throughput tests can be possible (Hartung, 2008a;2010b;Hartung and Koëter, 2008;Hartung and leist, 2008), using human cells Kuegler et al, 2010), response pathways (Alon, 2007), and evidence-based procedures (Hoffmann and Hartung, 2006;Hartung, 2009b) to develop scientifically sound "Integrated testing Strategies" (Jaworska and Hoffmann, 2010). there are ongoing efforts in which experts from animal welfare organizations work together with regulators to produce new drug development guidelines for the use of alternative methods to replace animal use.…”

What do you mean, Supply Chain Security? A Taxonomy and Framework for Knowledge Sharing

“…[33,36] There is strong evidence that modern assays developed and optimized for nanotoxicology will be adaptable to the benefit of toxicology and the other fields for which classical toxicology has become crucial. [37,38,39,40] The specific properties of nanoparticles illustrate the disadvantage of using regulation and protocols born of another field. The rapid construction of a useful framework that has been adapted to suit the new field demonstrates the advantages of this approach.…”