Follow‐up study on a susceptibility locus for schizophrenia on chromosome 6q

Martínez, María; Goldin, Lynn R.; Cao, Quihe; Zhang, Jing; Sanders, Alan R.; Nancarrow, Derek J.; Taylor, Jennifer; Levinson, Douglas F.; Kirby, Andrew; Crowe, Raymond R.; Andreasen, Nancy C.; Black, Donald W.; Silverman, Jeremy M.; Lennon, David P.; Nertney, Deborah A.; Brown, Donna; Mowry, Bryan; Gershon, Elliot S.; Gejman, Pablo V.

doi:10.1002/(sici)1096-8628(19990820)88:4<337::aid-ajmg9>3.3.co;2-1

Cited by 31 publications

(46 citation statements)

References 8 publications

(12 reference statements)

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“…Subsequent finemapping analysis of these regional findings, conducted at the Australian Genome Research Facility, provided support for the initial findings on chromosomes 2 and 10 [57]. To follow up the original 6q linkage finding by Pablo Gejman (Northwestern University, Chicago), we are collaborating with his group on linkage [70] and candidate gene studies [71][72][73] in this region. In addition, our group has continued to contribute to methodological issues [59,60,45] and to the analysis of the field's most prominent hot-spot regions both separately [62][63][64], and as part of multi-site collaborative analyses, including the investigation of defined chromosomal regions on 22q [65], 3p, 6p and 8p [66], Xp [67], on 5q, 6q, 10p and 13q [52] and more recently on 1q [68] and 22q [69].…”

Section: Independent and Collaborative Molecular Genetic Analysesmentioning

confidence: 82%

Queensland Centre for Mental Health Research: The First 17 Years

McGrath

Mowry

Whiteford

2005

Aust N Z J Psychiatry

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Section: Independent and Collaborative Molecular Genetic Analysesmentioning

confidence: 82%

Queensland Centre for Mental Health Research: The First 17 Years

McGrath

Mowry

Whiteford

2005

Aust N Z J Psychiatry

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“…This study is unique in that a second independent sample of families held by the same researchers was used to replicate the finding internally, and supported the results from the first sample. A further replication study by the same group found positive but less significant maxima in a third independent sample (Martinez et al, 1999). Combining the data from both replication samples, an interval of ~8 Mb gave the strongest results under both parametric and nonparametric approaches, with a LOD of 3.82 and highly significant excess allele sharing.…”

Section: Chromosome 6q21-q22 Linkage Studiesmentioning

confidence: 88%

Linkage studies of schizophrenia

Riley

2004

neurotox res

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The study of schizophrenia genetics has revealed much about the disease but none of the essential secrets of its etiology, so far, for numerous reasons. First, schizophrenia is a complex trait, influenced by both genes and environment. Second, it appears to be a highly heterogeneous disease, with locus and allelic heterogeneity both between and within families likely. Third, since it is common, it is likely that the genetic liability variants are common, and so are found with relatively high frequency in the general population. Fourth, linkage methods, which deliver rapid coverage of the genome, have great power to identify single genes causing Mendelian disorders but are poorly suited to the genetic architecture of complex traits. Although association methods are undeniably more powerful in such situations, affordable technologies to deliver the much higher density whole genome coverage required are not yet available and candidate gene studies of schizophrenia have not produced robust and replicable results. In spite of these limitations, there are now sufficient data to support several conclusions. Numerous regions of the human genome give consistent, though by no means unanimous, support for linkage. The precise nature of these signals is not yet understood, and power to position the effects is poor, but metanalyses show the co-occurrence is unlikely to be due to chance. Combined approaches utilizing linkage for rapid genome coverage and association for fine-scale follow-up have identified several promising candidate genes. Although the definition of replication in a complex trait is itself complex, a number of these candidates have been supported by numerous studies. These converging lines of evidence suggest that the genetics of schizophrenia, long considered a most intractable problem, are at last beginning to be unraveled.

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“…The CB1R gene is located in human chromosome 6q14-q15, and it is interesting that previous reports showed evidence for possible linkage to schizophrenia with chromosome 6q markers (Martinez et al, 1999). In addition, evidence exists for a schizophrenia susceptibility locus on chromosome 6q (Cao et al, 1997).…”

Section: Polymorphic Structure Of Cannabinoid Receptor Genesmentioning

confidence: 99%

Handbook of Neurochemistry and Molecular Neurobiology

2008

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Additionally, the whole set will be available upon completion under The electronic version of the whole set will be available under The print and electronic bundle of the whole set will be available under ISBN: 978-0-387-35478-1 ß 2008 Springer Science+Business Media, LLC.All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC., 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. springer.comPrinted on acid-free paper SPIN: 11416593 2109 -5 4 3 2 1 0 PrefaceThe brain is the organ that collects information from the environment, processes and stores the information, and generates behavior as and when needed. In essence, the brain makes us who we are. For this reason, understanding the biology of brain function is a great challenge and a major goal of modern science. The brain is one of the last great frontiers in science, and the unraveling of its mysteries is comparable in complexity to efforts in space exploration. Therefore, it was not a surprise that the U.S. Congress proclaimed the 1990s the ''Decade of the Brain,'' a movement also introduced by several other countries, thereby giving a chance for neuroscientists to focus on this topic and to have better conditions for their research.A fundamental goal of neuroscience is to understand how neurons generate behavior and the pathophysiology of different mental and neurological diseases. This requires, among other things, information about where these neurons are located, how they are connected, and how they communicate with each other in various physiological and pathophysiological conditions.At the end of the nineteenth century, the great neuroanatomist Santiago Ramon y Cajal recognized that neurons are the individual signaling elements of the brain. In this book, we focus on these nerve cells of the brain and the chemical molecules that allow them to talk to each other. The discovery of intercellular communication through endogenous molecules is a milestone in the history of science. It makes the brain a unique organ.Our aim is to describe recent discoveries about the basic operations of the brain and to provide an introduction to the adaptations for specific types of information processing. For example, at a chemical synapse, the presynaptic terminal liberates a transmitter substance that acts on the postsynaptic process. Thus, a synapse converts a presynaptic electrical signal into a chemical signal and back into a postsynaptic electrical signal.Cur...

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Follow‐up study on a susceptibility locus for schizophrenia on chromosome 6q

Cited by 31 publications

References 8 publications

Queensland Centre for Mental Health Research: The First 17 Years

Queensland Centre for Mental Health Research: The First 17 Years

Linkage studies of schizophrenia

Handbook of Neurochemistry and Molecular Neurobiology

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