Follow up study of dermal hyaluronic acid injection by high frequency ultrasound and magnetic resonance imaging

Josse, Gwendal; Haftek, Marek; Gensanne, D.; Turlier, Virginie; Mas, Amandine; Lagarde, Jean Michel; Schmitt, Anne-Marie

doi:10.1016/j.jdermsci.2009.12.012

Cited by 12 publications

(7 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An increasing number of methods are applied to determine the longevity of hyaluronic acid fillers in vivo, including histology, cytochemistry, magnetic resonance imaging, electron microscopy, and high-frequency ultrasound. 12 High-frequency ultrasound is a noninvasive approach for visualizing hyaluronic acid fillers and dermal modifications that can be performed without skin biopsies. Moreover, dermal changes over a long-term period can be monitored and quantified by the use of high-frequency ultrasound, in the event of cyst or granuloma induced by hyaluronic acid filler treatment.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Follow-Up of Longevity and Diffusion Pattern of Hyaluronic Acid in Nasolabial Fold Correction through High-Frequency Ultrasound

Qiao

Jia

Jin

et al. 2019

Plastic &Amp; Reconstructive Surgery

View full text Add to dashboard Cite

Background: Injectable hyaluronic acid fillers have been widely applied in the clinical treatment of facial wrinkles. However, further information and clinical evidence concerning dermal changes and hyaluronic acid filler longevity after injection and diffusion pattern are limited. Methods: The authors evaluated the longevity and diffusion pattern of two hyaluronic acid fillers generated by different cross-linking technologies used in the treatment of nasolabial folds using high-frequency ultrasound. Forty-one subjects were treated with Restylane 2 and the remaining 41 were treated with Dermalax DEEP. Wrinkle severity rating scale score and high-frequency ultrasound evaluation of nasolabial folds were performed before and after the injection of hyaluronic acid filler. The ultrasound images were acquired and analyzed to determine dermal thickness and the shape and distribution of hyaluronic acid filler. Results: At 2 and 24 weeks from baseline, increased dermal thickness induced by hyaluronic acid filler treatment was not significantly different between groups. At 48 weeks after injection, increased dermal thicknesses of the Restylane 2 group (0.14 ± 0.12 mm) were much lower than those of the Dermalax DEEP group (0.20 ± 0.13 mm). Ultrasound examination revealed that hyaluronic acid materials form well-demarcated and hypoechogenic areas. Restylane 2 tended to form a more diffuse pattern, with multiple smaller bubbles, whereas Dermalax DEEP developed into a more localized configuration, with larger clumps. Conclusions: This study is the first long-term assessment of nasolabial fold correction that reveals the performance of different hyaluronic acid materials in vivo and validates high-frequency ultrasound as a simple and rapid modality. Hyaluronic acid fillers generated by different cross-linking technologies display differential diffusion patterns in skin tissues. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.

show abstract

Section: Discussionmentioning

confidence: 99%

Long-Term Follow-Up of Longevity and Diffusion Pattern of Hyaluronic Acid in Nasolabial Fold Correction through High-Frequency Ultrasound

Qiao

Jia

Jin

et al. 2019

Plastic &Amp; Reconstructive Surgery

View full text Add to dashboard Cite

show abstract

“…In vivo, a region of HA filler appears as a hypoechoic delimited structure of low intensity or relatively low echogenicity (i.e., darker), as opposed to areas of edema, which appear as hypoechoic areas without defined limits. 11 The tonality or darkness of HA depends, among other factors, on the degree of viscosity and density of the product, but HA can easily be differentiated from anatomical structures by its distinct boundaries with surrounding soft tissues. 12 For locating and differentiating HA, it is also helpful for the operator to have thorough knowledge regarding US techniques and the anatomy of the region.…”

Section: Resultsmentioning

confidence: 99%

Ultrasonography for long-term evaluation of hyaluronic acid filler in the face: A technical report of 180 days of follow-up

Rocha

Rocha²,

Rocha³

et al. 2020

Imaging Sci Dent

View full text Add to dashboard Cite

Purpose: In this study, we used ultrasonography to monitor the use of hyaluronic acid (HA) as a filler in the face for esthetic reasons. We monitored changes in the filler shape, distribution, and relationship with adjacent anatomical structures over a 180-day period. Materials and Methods: Two patients each received an ultrasound-guided injection of HA, with different products and application sites for each patient. In 1 patient, the injection was administered in the angle of the mandible, while in the other, it was administered in the zygomatic region. The injection sites were monitored via ultrasonography at 24 hours, 30 days, and 180 days, at which times the imaging characteristics of the filler were observed. All injections were performed by the same professional, as were the ultrasound exams, which were conducted using the same equipment. Results: In both cases, the HA fillers were visualized using ultrasound at all time points. Some differences were observed between the cases in the images and the distribution of the pockets of filler. In 1 case, the filler appeared as a dark hypoechoic region with well-defined contours, and the material was observed to have moved posteriorly by the 180-day mark. In the other case, the material appeared hyperechoic relative to the previous case and presented no noticeable changes in its anteroposterior distribution over time. Conclusion:Based on these 2 cases, ultrasonography can be a complementary tool used to monitor facial fillers over the long term, allowing for the dynamic observation of different fillers.

show abstract

“…MRI seems to be the best diagnostic tool, allowing a correct assessment of filler dislocation due to multiplanar acquisitions and determination of anatomical landmarks. 14 Various studies have investigated MRI 1 5 14 15 as a diagnostic modality for accurately identifying the presence of foreign material. Grippaudo et al 14 showed that contrast-enhanced MRI enabled the identification of sub-cutaneous abscesses or granulomas characterized, respectively, by circular or diffuse enhancement.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging appearance of foreign-body granulomatous reactions to dermal cosmetic fillers

et al. 2017

View full text Add to dashboard Cite

Foreign body granulomas can develop after the injection of various cosmetic filling materials into the facial area to flatten wrinkles. Clinically, reactive lesions are easily mistaken for soft-tissue neoplasms or cysts. This report presents a case of foreign body granuloma in a 52-year-old female patient complaining of a painless swelling in the nasolabial region. Both clinical and histological features are described, underscoring the diagnostic role of magnetic resonance imaging findings.

show abstract

Follow up study of dermal hyaluronic acid injection by high frequency ultrasound and magnetic resonance imaging

Cited by 12 publications

References 11 publications

Long-Term Follow-Up of Longevity and Diffusion Pattern of Hyaluronic Acid in Nasolabial Fold Correction through High-Frequency Ultrasound

Long-Term Follow-Up of Longevity and Diffusion Pattern of Hyaluronic Acid in Nasolabial Fold Correction through High-Frequency Ultrasound

Ultrasonography for long-term evaluation of hyaluronic acid filler in the face: A technical report of 180 days of follow-up

Magnetic resonance imaging appearance of foreign-body granulomatous reactions to dermal cosmetic fillers

Contact Info

Product

Resources

About