Follicular Mucinosis

Gibson, Lawrence E.

doi:10.1001/archderm.138.12.1615

Cited by 7 publications

(6 citation statements)

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“…[18][19][20][21] Mucinous degeneration of the follicular epithelia has always been considered a very typical and defining feature of so-called ''MF-associated follicular mucinosis.'' [22][23][24][25][26][27] However, as previously reported, follicular mucinosis in folliculotropic MF is not a constant feature. 4,[28][29][30] In almost 50% of our cases, after sectioning, no follicular mucinosis could be identified.…”

Section: Discussionmentioning

confidence: 67%

Folliculotropic mycosis fungoides: Clinicopathological features and outcome in a series of 20 cases

Muniesa

Estrach

Pujol³

et al. 2010

Journal of the American Academy of Dermatology

105

121

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Section: Discussionmentioning

confidence: 67%

Folliculotropic mycosis fungoides: Clinicopathological features and outcome in a series of 20 cases

Muniesa

Estrach

Pujol³

et al. 2010

Journal of the American Academy of Dermatology

105

121

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“…It is generally accepted that, in patients with limited disease (primarily of the head and neck) at the time of presentation, the condition typically runs a benign course . In a study of 33 individuals with FM, initial lesions were on the head and neck in 44% and on the trunk or extremities in 56% of those with MF, but were on the head and neck in 58% and on the trunk or extremities in 42% of those without MF .…”

Section: Discussionmentioning

confidence: 99%

Pediatric Follicular Mucinosis: Presentation, Histopathology, Molecular Genetics, Treatment, and Outcomes over an 11‐Year Period at the Mayo Clinic

Alikhan

Griffin

Nguyen

et al. 2012

Pediatric Dermatology

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Follicular mucinosis (FM) and folliculotropic mycosis fungoides (MF) are rare in children, and data regarding long-term outcomes are limited. We sought to describe clinical and histopathologic findings of children with FM with and without MF, as well as treatments administered and clinical outcomes. We conducted a retrospective chart review of patients younger than 22 years (at time of diagnosis) with a biopsy demonstrating FM who were seen in the Dermatology Department at the Mayo Clinic from September 1, 1999, to September 1, 2010. Eleven patients (six male, five female) ages 11 to 19 years at the time of diagnosis met the inclusion criteria. Follow-up data were available for 10 patients, with a mean duration of 4.9 years. The head, neck, and extremities were the most common sites of involvement, and lesions were follicular-based papules (18%), scaly alopecic patches and plaques (45%), or a combination of the two (36%). Overall, three patients were confirmed to have MF. T-cell receptor gene rearrangement demonstrated clonality in two cases and was equivocal in one case. Treatments included topical corticosteroids, topical retinoids, oral minocycline, and, in patients with MF, ultraviolet light and topical bexarotene. Lesions resolved completely in seven patients, partially in one, and not at all in two (no follow-up data on one patient). Of the three patients with MF, two had complete resolution, and one has intermittent flares. To our knowledge, no patients developed other lymphoproliferative disorders. FM in children is rare. A histopathologic diagnosis of FM does not equate to folliculotropic MF in all cases. Most patients responded to treatment with topical steroids, topical retinoids, or phototherapy. In our series of patients, the disease ran a benign course.

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“…Distinguishing between the clinical entity of follicular mucinosis (alopecia mucinosa) and FMF can be challenging histologically. 6,[14][15][16][17] Some authors have proposed that mycosis fungoides, follicular mucinosis, and FMF represent conditions along a continuous spectrum. 18 Accurate diagnosis is important because follicular mucinosis unassociated with mycosis fungoides, especially in young patients, tends to have a persistent but benign disease course, 15 in contrast to FMF.…”

Section: Systematic Reviewmentioning

confidence: 99%

Folliculotropic Mycosis Fungoides

et al. 2010

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To clarify clinicopathologic features and reconcile discrepancies in previous studies of folliculotropic mycosis fungoides (FMF).Design: A single-center retrospective clinicopathologic study and a systematic review of FMF.Setting: Tertiary referral center in the midwestern United States.Patients: Patients with clinical and histopathologic evidence of FMF seen at the tertiary referral center during a 12 1 ⁄2-year period.Main Outcome Measures: Clinicopathologic features of FMF.Results: Fifty patients (32 male [64%] and 18 female [36%]) met study criteria for the clinicopathologic review. Pruritic patches, plaques, and folliculocentric lesions (milia, cysts, and alopecia) on the head, neck, and

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Follicular Mucinosis

Cited by 7 publications

References 0 publications

Folliculotropic mycosis fungoides: Clinicopathological features and outcome in a series of 20 cases

Folliculotropic mycosis fungoides: Clinicopathological features and outcome in a series of 20 cases

Pediatric Follicular Mucinosis: Presentation, Histopathology, Molecular Genetics, Treatment, and Outcomes over an 11‐Year Period at the Mayo Clinic

Folliculotropic Mycosis Fungoides

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