Follicular Helper T Cells in Peripheral Blood of Patients With Rheumatoid Arthritis

Costantino, Alicia Beatriz; Acosta, Cristina; Onetti, Laura; Mussano, Eduardo; Cadile, Isaac; Ferrero, Paula Gallego

doi:10.1016/j.reumae.2016.07.011

Cited by 9 publications

(8 citation statements)

References 28 publications

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“…In seven studies, it was observed increased frequencies of cTfh cells in the patients [32,[35][36][37][38][39][40] and some authors found association with the disease activity [36,[38][39][40] and with autoantibody titers [32,36,37,40]. By contrast, other ones did not found the increase of cTfh cells nor differences in the percentages of cTfh1, cTfh2, and cTfh17 subsets in RA patients, compared to healthy controls or patients with undifferentiated arthritis [41,42]. To summarize, cTfh cell, especially cTfh17 cells, could be increased in RA and might have pathogenetic roles (Table 1).…”

Section: Rheumatoid Arthritismentioning

confidence: 96%

T follicular helper cell subsets: a potential key player in autoimmunity

Kurata

Matsumoto

Sumida

2020

Immunological Medicine

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Follicular helper T (Tfh) cells are one of CD4þ helper T subsets which promote B cell maturation, activation and antigen-specific antibody production. Autoantibodies are hallmarks of autoimmune diseases, and crucial contributions of Tfh cells in development of these diseases are now evident. Deregulation of Tfh activities can contribute to a pathogenic autoantibody production and can play an important role in the promotion of autoimmune diseases. These days multiple researchers reported three subpopulations which has distinct effector functions in Tfh cells: Tfh1, Tfh2 and Tfh17 cells. In this review, we summarize the observed alterations in whole Tfh cells and subset distribution during autoimmune diseases.

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Section: Rheumatoid Arthritismentioning

confidence: 96%

T follicular helper cell subsets: a potential key player in autoimmunity

Kurata

Matsumoto

Sumida

2020

Immunological Medicine

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“…In initial step, we carried out meta-analysis to compare the proportion of Tfh cells between RA and HC groups regardless of the markers used for de nition of Tfh cells. Some of these studies reported a signi cant increase in the proportion of Tfh cells in BP of RA versus HC subjects [22][23][24][25][26][27][28][29][30][31][32][33][34], some studies showed no differences [35][36][37][38][39], some studies revealed both increase in RA and no differences between the two groups depending on the de nition markers [40][41][42][43], and some other reported non-signi cant decrease in Tfh cells proportion in RA group [44,45]. Based on the pooled result of meta-analysis, RA patients had a signi cantly higher proportion of cTfh cells compared with HCs (SMD 0.75, [0.56, 0.93], p < 0.0001), although high level of heterogeneity (I 2 = 80.15, p < 0.0001) was observed between studies (Fig.…”

Section: Pooled Resultsmentioning

confidence: 99%

“…First we analyzed the studies in which "CD4 + CXCR5 + " was used to identify Tfh cells. From a total of 15 studies, 7 studies found higher frequency of Tfh cells in BP of patients with RA compared to HCs [22][23][24][25][26][27]34], 7 studies showed no difference [35][36][37][40][41][42][43], and 1 study reported non-signi cant decrease in proportion of Tfh cells in RA group [45]. Analysis of the pooled effect size of the 15 studies revealed that RA patients had a signi cant increased Tfh cells proportion in comparison with the HC group when Tfh cell was de ned as "CD4 + CXCR5 + " (SMD 0.6, [0.23, 0.96], p = 0.001; I 2 = 86.23%, p < 0.0001) (Supplementary Fig.…”

Section: Subgroup Analysismentioning

confidence: 99%

“…A total of 12 articles covering 21 studies evaluated the proportion of Tfh cells in patients who did not take any medicine at the time of sample collection. Of these, some of studies included patients who didn't receive any drug for at least 1 month [22], 2 months [30,35] and 3 months [32,36,42] before blood sample collection, and 6 articles covering 12 studies included patients with lack of any treatment history [23,26,27,29,38,43]. Therefore, the proportion of Tfh cells was compared between RA patients without immunosuppressive treatments and HCs.…”

Section: Subgroup Analysismentioning

confidence: 99%

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Proportion of T follicular helper cells in peripheral blood of rheumatoid arthritis patients: a systematic review and meta-analysis

Bemani

Eklund

Ali‐Hassanzadeh

et al. 2021

Expert Review of Clinical Immunology

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Objectives: Follicular helper T (Tfh) cells have critical roles in the development and promotion of humoral immune responses. Accumulating evidence points to alterations in the levels and activity of Tfh which may lead to impaired immune tolerance and development of antibody-mediated autoimmune diseases, such as rheumatoid arthritis (RA). To elucidate the status of Tfh cells in patients with RA, we conducted a systematic review and meta-analysis to assess the proportion and types of Tfh cells in the PB of RA patients.Method: We systematically searched databases of Embase, Pubmed, Web of sciences (WOS), and Scopus to identify the eligible articles. We performed meta-analysis to assess the proportion of Tfh cells in PB of RA patients compared to healthy controls (HCs). We also assessed the proportion of Tfh cells based on different parameters including Tfh de nition markers, disease activity status, disease stage, treatment status, serum markers, and the geographical location of the included articles.Results: Regardless of de nition markers, the proportion of Tfh cells in RA patients was signi cantly higher than that in HCs (SMD 0.75, [0.56, 0.93], p<0.0001). Based on subgroup analyses, the proportion of Tfh cells with the individual de nitions were also signi cantly higher in PB of RA patients compared to HCs. Tfh cells proportion in untreated-RA and early-RA patients was markedly greater than HCs, when comparisons were made without considering the de nition markers, and also when Tfh cells was de ned by the speci ed de nition markers. While the proportion of Tfh cells by all de nitions was signi cantly higher in active-and remission-RA compared to HCs, individual analysis of two de nitions, CD4 + CXCR5 + and CD4 + CXCR5 + ICOS + , didn't show signi cant differences. In addition, higher proportion of Tfh cells de ned by all de nitions as well as a speci ed de nition (CD4 + CXCR5 + PD-1 high ) was observed when S + RA and S -RA patients were compared to the HCs. Higher Tfh cells proportion in RA patients compared with HCs was observed in the Asian populations (SMD 0.89, [0.68, 1.09], p<0.0001), while there was a trend toward signi cant in the proportion of Tfh between the two groups in non-Asians (SMD 0.29, [-0.003, 0.59], p=0.052). Conclusion:Altogether, our results demonstrate that circulating Tfh are highly elevated in RA patients and are also signi cantly increased in untreated-, early-and S + -RA patients, underscoring the potential pathogenic role of this cell population in RA and its potential use as a biomarker and a target for RA therapy.HCs. Hence, in the present work, we systematically searched and reviewed the available studies documenting the proportion of Tfh among CD4 + T cells in PB of RA patients, and conducted a meta-analysis to elucidate the proportion of Tfh cells in the PB of RA patients compared to the HCs. Materials And Methods Search StrategyThis study was carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was registe...

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“…The aetio-pathogenic mechanisms include an interaction between the innate and adaptive immune response that involves antigen-presenting cells, the formation of autoreactive T cells and the production of autoantibodies, such as RF and ACPAs [3]. Thus, RA may be considered a prototype of autoimmune disease, with the hallmarks of synovial inflammation and presence of autoantibodies [4].…”

Section: Introductionmentioning

confidence: 99%