Follicular fluid levels of inhibin A, inhibin B, and activin A levels reflect changes in follicle size but are not independent markers of the oocyte’s ability to fertilize

Wen, Xuesong; Tozer, Amanda; Butler, Stephen A.; Bell, Celia M.; Docherty, Suzanne M.; Iles, Ray K.

doi:10.1016/j.fertnstert.2005.11.058

Cited by 39 publications

(28 citation statements)

References 18 publications

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“…Elevated follicular fluid levels of inhibin B and estradiol have been reported to be associated with ovarian response, high quality of oocytes, and high fertilization and pregnancy rates (22)(23)(24), but the reverse also has been reported by some studies (15,23,25). In our study, the follicular fluid levels of inhibin B, estradiol, and progesterone were not statistically significantly different in the fertilized group and the nonfertilized group.…”

Section: Discussionsupporting

confidence: 66%

Anti-Müllerian hormone substance from follicular fluid is positively associated with success in oocyte fertilization during in vitro fertilization

Takahashi

Fujito

Kazuka

et al. 2008

Fertility and Sterility

108

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Section: Discussionsupporting

confidence: 66%

Anti-Müllerian hormone substance from follicular fluid is positively associated with success in oocyte fertilization during in vitro fertilization

Takahashi

Fujito

Kazuka

et al. 2008

Fertility and Sterility

108

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“…Furthermore, since it has been suggested that serum inhibin B in relation to male and female reproductive health have been published internationally and the risk of leukemia that may spread to other organs like ovary (Ahmed et al, 2001;Wen et al, 2006;Lee et al, 2008;Moos et al, 2009;Taflan et al, 2011;Dillon and Gracia, 2012), the present study attempt to clarify the correlation between inhibin and serum protein, glutathione and the two vitamins E and C in patients with ALL, the results were reanalyzed by using linear regression analysis, Table 2.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Inhibin and Several Antioxidants in Children with Acute Lymphoblastic Leukemia

Mehde¹,

Mehdi²,

Zainulabdeen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Acute lymphoblastic leukemia (ALL) is most common in childhood. Inhibin (a non-steroidal glycoprotein hormone of gonadal origin) can be used as marker of fertility. The current study was conducted to evaluate inhibin levels in ALL patients and to estimate its correlation with some antioxidants in these in comparison with control subjects. Materials and Methods: This study was conducted on sixty patients with ALL and thirty children as controls. Fasting blood samples were taken from each subject and analyzed for haemoglobin, serum protein, vitamin E and C, in addition to glutathione and inhibin. Results: The results of the study showed highly significant decreases (p<0.001) in haemoglobin, glutathione and inhibin levels with significant decreases (p<0.05) in serum protein and vitamin E levels for patients group in comparison with controls while there was no significant differences in vitamin C. Moreover, there were significant correlations between inhibin levels and serum protein, glutathione and both vitamins (E and C) in the ALL patient group (r= 0.81, 0.80, 0.77 and 0.69, respectively). Conclusions: The present results indicated infertility in patients with ALL demonstrated by low inhibin level as a consequence of abnormality in anti-oxidative metabolism due to the cancer process. So, it can be suggested the need for routine measurement of inhibin for leukemic patients to estimate the action of hormones of gonadal origin.

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“…The details of patients' selection and treatment are described elsewhere [11]. The procedure for FF aspiration involved random selection of individual follicles measured in two dimensions by transvaginal ultrasound (Hitachi, model EUB-525, Northants UK) in order to obtain a mean diameter.…”

Section: Patient Selection and Sample Collectionmentioning

confidence: 99%

Capillary electrophoresis of human follicular fluid

Wen

Perrett

Patel

et al. 2009

Journal of Chromatography B

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Some of the major serum proteins that are also found in follicular fluid, including transferrin, -macroglobulin and albumin, are thought to play a role in oocyte maturation. This study set out to identify proteins in human follicular fluid by capillary zone electrophoresis and to investigate their relationship to follicular/oocyte maturity and fertility outcome.176 individual follicular fluid samples, from 30 women undertaking in vitro fertilization/ intracytoplasmic sperm injection (IVF/ICSI), were run using an optimized capillary zone electrophoresis method that gave a good separation of sixteen peaks in most samples. Nine of the peaks were identified and quantified but seven remain unknown and require further proteomic identification. Of the identified protein peaks, levels of each were corrected for follicular volume and total content calculated. No significant difference in protein levels was found with regard to oocyte recovery and fertilization. Protein concentrations tended to decrease as the follicular sphere increased whilst total content in follicular fluid increased in proportion to size. This is consistent with simple transudation across a sphere surface area which does not increase in proportion to the follicular fluid. This is not true of the concentration and content pattern of other proteins/biomolecules which are produced by follicular cells locally.In conclusion, neither concentration nor absolute levels of nine major proteins identified in follicular fluids correlated with oocyte presence and fertility outcome. Future work to remove more concentrated proteins (e.g. albumin) would enhance separation of smaller peaks and identification of the unknown molecules.

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Follicular fluid levels of inhibin A, inhibin B, and activin A levels reflect changes in follicle size but are not independent markers of the oocyte’s ability to fertilize

Cited by 39 publications

References 18 publications

Anti-Müllerian hormone substance from follicular fluid is positively associated with success in oocyte fertilization during in vitro fertilization

Anti-Müllerian hormone substance from follicular fluid is positively associated with success in oocyte fertilization during in vitro fertilization

Correlation of Inhibin and Several Antioxidants in Children with Acute Lymphoblastic Leukemia

Capillary electrophoresis of human follicular fluid

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