Follicular Dominance in Cattle Is Associated With Divergent Patterns of Ovarian Gene Expression for Insulin-Like Growth Factor (IGF)-I, IGF-II, and IGF Binding Protein-2 in Dominant and Subordinate Follicles

Yuan, Wenzhen; Bao, Bagna; Garverick, H.A.; Youngquist, R.S.; Lucy, M.C.

doi:10.1016/s0739-7240(97)00062-3

Cited by 72 publications

(54 citation statements)

References 29 publications

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“…circles, subordinate follicles; triangles, partially dominant follicles; diamonds, fully dominant follicles. (Bao et al 1997, Yuan et al 1998 or using gene expression profiling (Malhi et al 2005, Zielak et al 2007) with a view to understand the regulation of dominance. However, follicular dominance is also associated with a greater increase in size of the dominant follicle over the subordinate follicle leading eventually to its atresia.…”

Section: Discussionmentioning

confidence: 99%

Studies of granulosa cell maturation in dominant and subordinate bovine follicles: novel extracellular matrix focimatrix is co-ordinately regulated with cholesterol side-chain cleavage CYP11A1

Irving-Rodgers¹,

Harland²,

Sullivan³

et al. 2009

Reproduction

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During growth of antral ovarian follicles granulosa cells first become associated with a novel type of extracellular matrix, focimatrix, and at larger sizes follicles become either subordinate or dominant. To examine this, bovine subordinate (9.0GS.E.M. 0.4 mm; nZ16), partially dominant (12.0G0.6 mm; nZ18) and fully dominant (15.0G0.4 mm; nZ14) follicles were examined by real time RT-PCR analyses of granulosa cells and by immunohistochemistry of focimatrix. Changes in the expression of FSH receptor, LH receptor, cholesterol side-chain cleavage (CYP11A1), 3b-hydroxysteroid dehydrogenase, aromatase (CYP19A1) and inhibin-a and b-B were observed as expected for follicle sizes examined. After adjusting for size differences, only CYP11A1 was significantly different between the groups, and elevated in dominant follicles. Also after adjusting for differences in size there were no significant differences in expression of focimatrix components collagen type IV a-1 (COL4A1), laminin b-2, nidogen 1 (NID1), and perlecan (HSPG2) or the volume density of NID1 and -2 and HSPG2. The volume density of focimatrix components in laminin 111 was significantly elevated in dominant follicles. Adjusting for analysis of more than one follicle per animal and for multiple correlations, CYP11A1 mRNA levels were highly correlated with the focimatrix genes COL4A1, NID1 and -2 and HSPG2. Thus, focimatrix may potentially regulate CYP11A1 expression, and the regulation of both could be important in follicular dominance. Reproduction (2009) 137 825-834

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Section: Discussionmentioning

confidence: 99%

Studies of granulosa cell maturation in dominant and subordinate bovine follicles: novel extracellular matrix focimatrix is co-ordinately regulated with cholesterol side-chain cleavage CYP11A1

Irving-Rodgers¹,

Harland²,

Sullivan³

et al. 2009

Reproduction

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“…IGFBP-3 is produced by the liver and is the main high molecular weight BP found in serum. It is also found in bovine follicular fluid where local production does not take place [26,54,93]. Therefore, IGF-I in large normal follicles is derived at least in part, from the circulatory pool in vivo.…”

Section: Endocrine Effects Of Igf-i On Reproductive Functionmentioning

confidence: 99%

Insulin-Like Growth Factor-I as a Possible Hormonal Mediator of Nutritional Regulation of Reproduction in Cattle

Zulu

Nakao

Sawamukai

2002

The Journal of Veterinary Medical Science

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ABSTRACT. The current review aims to establish insulin-like growth factor-1 (IGF-I) as the factor that signals nutritional status to the reproductive axis, and show that assessment of IGF-I in blood early postpartum during the negative energy balance (NEB) period could be used to predict both nutritional and reproductive status in dairy cattle. The review also explores the effect of nutritional status on circulating IGF-I concentrations and the endocrine role of IGF-I on the reproductive axis. IGF-I plays an important role in gonadotropininduced folliculogenesis, ovarian steroidogenesis and corpus luteum (CL) function. It also modulates pituitary and hypothalamus function. IGF-I clearly has an endocrine role on the reproductive axis. Severe under nutrition significantly reduces plasma IGF-I concentrations. During the critical period of NEB in high yielding dairy cattle early postpartum, IGF-I concentrations are low in blood and its levels are positively correlated to energy status and reproductive function during this period. Changes in circulating IGF-I immediately postpartum may help predict both nutritional and reproductive status in dairy cattle. IGF-I is therefore one of the long sought factors that signal nutritional status to the reproductive axis.

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“…Previous studies have used the bovine DF model to examine changes in the expression of known follicular genes (such as for FSH and LH receptors, steroidogenic enzymes, specific growth factors and their binding proteins) when the DF becomes selected from the cohort , Yuan et al 1998, Canty et al 2006. While this candidate gene approach has merit, it is clear that approaches that utilise global gene and protein expression profiling are required to identify all key factors and pathways which regulate cell differentiation during DF development.…”

Section: Introductionmentioning

confidence: 99%

Differentiation of the bovine dominant follicle from the cohort upregulates mRNA expression for new tissue development genes

Mihm¹,

Baker²,

Fleming³

et al. 2008

Reproduction

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This study was designed to identify genes that regulate the transition from FSH-to LH-dependent development in the bovine dominant follicle (DF). Serial analysis of gene expression (SAGE) was used to compare the transcriptome of granulosa cells isolated from the most oestrogenic growing cohort follicle (COH), the newly selected DF and its largest subordinate follicle (SF) which is destined for atresia. Follicle diameter, follicular fluid oestradiol (E) and E:progesterone ratio confirmed follicle identity. Results show that there are 93 transcript species differentially expressed in DF granulosa cells, but only 8 of these encode proteins known to be involved in DF development. Most characterised transcripts upregulated in the DF are from tissue development genes that regulate cell differentiation, proliferation, apoptosis, signalling and tissue remodelling. Semiquantitative real-time PCR analysis confirmed seven genes with upregulated (P%0.05) mRNA expression in DF compared with both COH and SF granulosa cells. Thus, the new genes identified by SAGE and real-time PCR, which show enhanced mRNA expression in the DF, may regulate proliferation (cyclin D2; CCND2), prevention of apoptosis or DNA damage (growth arrest and DNA damage-inducible, b; GADD45B), RNA synthesis (splicing factor, arginine/serine rich 9; SFRS9) and unknown processes associated with enhanced steroidogenesis (ovary-specific acidic protein; DQ004742) in granulosa cells of DF at the onset of LH-dependent development. Further studies are required to show whether the expression of identified genes is dysregulated when abnormalities occur during DF selection or subsequent development.

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Follicular Dominance in Cattle Is Associated With Divergent Patterns of Ovarian Gene Expression for Insulin-Like Growth Factor (IGF)-I, IGF-II, and IGF Binding Protein-2 in Dominant and Subordinate Follicles

Cited by 72 publications

References 29 publications

Studies of granulosa cell maturation in dominant and subordinate bovine follicles: novel extracellular matrix focimatrix is co-ordinately regulated with cholesterol side-chain cleavage CYP11A1

Studies of granulosa cell maturation in dominant and subordinate bovine follicles: novel extracellular matrix focimatrix is co-ordinately regulated with cholesterol side-chain cleavage CYP11A1

Insulin-Like Growth Factor-I as a Possible Hormonal Mediator of Nutritional Regulation of Reproduction in Cattle

Differentiation of the bovine dominant follicle from the cohort upregulates mRNA expression for new tissue development genes

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