Follicular degeneration syndrome in men

Sperling, L. C.

doi:10.1001/archderm.130.6.763

Cited by 28 publications

(30 citation statements)

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“…43 However, foci of alopecia, even in the same mouse, may spread centrifugally with expanding cicatricial foci, very similar to that observed in CCCA. 7,36–38 Hair regrowth was not clinically apparent in the residual scars in the mice as expected due to complete hair follicle destruction. The majority of the microscopically identified dystrophic hair follicles were adjacent to the fibrotic areas of the specimens in an area with normal hair regrowth.…”

Section: Discussionsupporting

confidence: 56%

Primary Follicular Dystrophy With Scarring Dermatitis in C57BL/6 Mouse Substrains Resembles Central Centrifugal Cicatricial Alopecia in Humans

et al. 2010

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A number of C57BL/6 (B6) substrains are commonly used by scientists for basic biomedical research. One of several B6 strain specific background diseases is focal alopecia that may resolve or progress to severe, ulcerative dermatitis. Clinical and progressive histologic changes of skin disease commonly observed in C57BL/6J and preliminary studies in other closely related substrains are presented. Lesions develop due to a primary follicular dystrophy with rupture of severely affected follicles leading to formation of secondary foreign body granulomas (trichogranulomas) in affected B6 substrains of mice. Histologically these changes resemble the human disease called central centrifugal cicatrical alopecia (CCCA). Four B6 substrains tested have a polymorphism in alcohol dehydrogenase 4 (Adh4) that reduces its activity and potentially affects removal of excess retinol. Using immunohistochemistry, differential expression of epithelial retinol dehydrogenase (DHRS9) was detected which may partially explain anecdotal reports of frequency differences between B6 substrains. The combination of these two defects have the potential to make high dietary vitamin A levels toxic in some B6 substrains while not affecting most other commonly used inbred strains.

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Section: Discussionsupporting

confidence: 56%

Primary Follicular Dystrophy With Scarring Dermatitis in C57BL/6 Mouse Substrains Resembles Central Centrifugal Cicatricial Alopecia in Humans

et al. 2010

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“…Most of the histologic findings seen in early AK are virtually identical to those found in another form of primary scarring alopecia, namely central centrifugal scarring alopecia (CCSA), also known as the follicular degeneration syndrome, 17,18 hot-comb alopecia, 17,19 and pseudopelade of the vertex/crown. 20,21 This does not imply that AK is the same disease as CCSA since different diseases commonly result in similar histopathologic changes.…”

Section: Commentmentioning

confidence: 71%

“…roids, such as fluocinonide, along with prolonged use of an oral antibiotic, such as tetracycline, is of considerable benefit in the treatment of both CCSA 18 and AK. Both conditions are characterized by rather extensive subclinical disease and are chronic and progressive, requiring long-term prophylactic treatment.…”

mentioning

confidence: 99%

Acne Keloidalis Is a Form of Primary Scarring Alopecia

Sperling¹,

Homoky²,

Pratt³

et al. 2000

Arch Dermatol

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“…11,12 The histological findings of advanced lesions in our patients share features with the recently described follicular degeneration syndrome observed in black patients. 13,14 Also, the clinical presentation of these black women might mimic female pattern AGA because it pro- duces frontovertical alopecia. 13 The earliest observable histological abnormalities considered distinctive of this disorder are premature degeneration of the inner root sheath and migration of the hair shaft through the outer root sheath, 13 whereas the follicular interface dermatitis present in most of our patients is not a feature.…”

Section: Commentmentioning

confidence: 99%