Follicular Colonization in B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue

Isaacson, Peter G.; Wotherspoon, Andrew; Diss, Tim C.; Pan, Langxing

doi:10.1097/00000478-199109000-00001

Cited by 224 publications

(86 citation statements)

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“…Classically, MALT lymphomas reveal a histological triad composed of reactive lymphoid follicles, diffuse infiltration of small irregular lymphocytes (centrocytes), and lymphoepithelial lesions (LELs). The histological features closely simulate those of Peyer's patches [14] . The lymphoma infiltrates, around reactive follicles in the region corresponding to the marginal zone, were found to be spreading diffusely into the surrounding mucosa.…”

Section: Discussionsupporting

confidence: 52%

Primary gastric mucosa associated lymphoid tissue lymphoma: Clinical data predicted treatment outcome

Todorović¹,

Balint²,

Jevtic³

et al. 2008

WJG

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AIM:To determine clinical characteristics and treatment outcome of gastric lymphoma after chemotherapy and immuno-chemotherapy. METHODS:Thirty four patients with primary gastric mucosa associated lymphoid tissue (MALT) lymphoma (Ann Arbor stages Ⅰ to Ⅳ) were enrolled. All had upper gastric endoscopy, abdominal ultrasonography, CT and H pylori status assessment (histology and serology). After anti-H pylori treatment and initial chemotherapy, patients were re-examined every 4 mo. RESULTS:Histological regression of the lymphoma was complete in 22/34 (64.7%) and partial in 9 (26.5%) patients. Median follow up time for these 31 responders was 60 mo (range 48-120). No regression was noted in 3 patients. Among the 25 (73.5%) H pylori positive patients, the eradication rate was 100%. CONCLUSION:Using univariate analysis, predictive factors for overall survival were international prognostic index (IPI) score, hemoglobin level, erythrocyte sedimentation rate (ESR), and platelet numbers (P < 0.005). In addition to this, Cox proportion hazard model differentiate IPI score, ESR, and platelets as predictors of survival.

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Section: Discussionsupporting

confidence: 52%

Primary gastric mucosa associated lymphoid tissue lymphoma: Clinical data predicted treatment outcome

Todorović¹,

Balint²,

Jevtic³

et al. 2008

WJG

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“…98 The absence of CD10 in gastric lymphoma with an apparent follicular architecture has been rationalized by the concept of ''follicular colonization.'' 11 As noted earlier, follicular colonization refers to the replication of follicular lymphoma as a result of invasion by the marginal zone cells of MALT into preexisting reactive follicles ( Figure 6, E and F).…”

Section: Gastric Lymphomas Especially Marginal Zone Lymphomas Of Malmentioning

confidence: 76%

“…Frequently, the neoplastic marginal zone lymphocytes invade the germinal centers in a process referred to as ''follicular colonization.'' 11 When follicles are numerous, follicular colonization may imitate follicular lymphoma. In some cases, the lymphomatous infiltrate may result in architectural destruction with concealment of remaining germinal centers; however, the presence of cryptic germinal centers can be accentuated by the immunohistochemical demonstration of follicular dendritic cells with an antibody against CD21 or CD23.…”

Section: 30mentioning

confidence: 99%

“…Since the initial descriptions of lymphomas of MALT in 1983 and 1984, the morphologic criteria have evolved and expanded to encompass the following: a more precise definition of various cell types in MALT lymphoma, proposals for ''lymphoepithelial lesions'' and ''follicular colonization,'' the relationship between MALT lymphomas and marginal zone B cells, and a scoring system for diagnosis of gastric MALT lymphoma. [7][8][9][10][11][12] Moreover, the morphologic criteria have expanded to embrace immunophenotypic, biologic, molecular genetic, and clinical discoveries. 9,[13][14][15][16][17][18] Developments, such as the association of gastric MALT lymphoma with H pylori infection, the notion of acquired MALT, the biology of autoantigen activation and continuous somatic mutations, the documentation of genetic aberrations, for example, the discovery of the t(11;18)(q21;q21) chromosomal translocation in lymphomas of MALT, and the clinical implications of specific cytogenetic alterations, have been the subject of excellent reviews and will not be recapitulated to any degree.…”

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confidence: 99%

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Lymphoproliferative Disorders of the Gastrointestinal Tract: A Review and Pragmatic Guide to Diagnosis

Burke

2011

Archives of Pathology &Amp; Laboratory Medicine

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Context.—The gastrointestinal tract is the most common site of extranodal lymphomas. Although all histologic categories of malignant lymphoma develop in the gastrointestinal tract, large B-cell lymphomas predominate, followed by extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) type; the latter is especially prevalent in stomach. The acceptance of extranodal marginal zone lymphoma of MALT type as a clinicopathologic entity has reduced the number of cases that formerly were interpreted as florid lymphoid hyperplasia (“pseudolymphoma”). Nonetheless, the distinction of lymphoid hyperplasia from a lymphoma of MALT type in small biopsy specimens remains problematic. Objective.—To assess the relevant morphologic, immunologic, molecular, and genetic properties of gastrointestinal lymphomas and to present a feasible tactic for diagnosis, expressly for small biopsy specimens. Data Sources.—Case-derived material and literature review using PubMed (National Library of Medicine). Conclusions.—Most gastrointestinal lymphomas are readily amenable to an unqualified diagnosis, primarily those cases consisting of monomorphic large cells whether of B- or T-cell lineage, including cases associated with enteropathy. Diagnosis for infiltrates dominated by small lymphocytes remains taxing, as the differential diagnosis embraces not only MALT lymphoma and lymphoid hyperplasia but also mantle cell lymphoma, follicular lymphoma, and chronic lymphocytic leukemia/small lymphocytic lymphoma. Adherence to strict morphologic criteria is the standard for diagnosis, but these criteria should be augmented by immunologic studies together with judicious use of molecular techniques to determine clonality. In establishing a diagnosis of gastric marginal zone lymphoma of MALT type, determination of t(11;18)(q21;q21) status may be required since this translocation has clinical ramifications.

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“…The latter cases may morphologically mimic follicular lymphoma. 10 Studies that have examined gastric resection specimens in patients with MALT lymphoma have highlighted the presence of a small neoplastic infiltrate derived from the same neoplastic clone as the main lymphoma around most of the lymphoid follicles in the gastric mucosa distant from the main lesion. 11,12 The distinction between acquired lymphoid tissue with the characteristics of MALT and early MALT lymphoma can be problematic.…”

Section: Extranodal Marginal Zone Lymphoma Of Mucosa-associated Lymphmentioning

confidence: 99%

Extranodal and splenic small B-cell lymphoma

Wotherspoon

2013

Modern Pathology

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Follicular Colonization in B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue

Cited by 224 publications

References 0 publications

Primary gastric mucosa associated lymphoid tissue lymphoma: Clinical data predicted treatment outcome

Primary gastric mucosa associated lymphoid tissue lymphoma: Clinical data predicted treatment outcome

Lymphoproliferative Disorders of the Gastrointestinal Tract: A Review and Pragmatic Guide to Diagnosis

Extranodal and splenic small B-cell lymphoma

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