Abstract:This study tested the hypothesis that FSH promotes bone loss by inducing secretion of bone‐resorbing cytokines or by altering their receptor expression. Thirty six women (20–50 years old) were assessed for bone mineral density (BMD), circulating FSH, cytokine and soluble receptor concentrations, and expression of cytokine receptors on monocytes. Isolated mononuclear cells were also incubated in vitro with FSH. The results indicated that BMD was inversely related to serum FSH (R: −0.36 to −0.52, P: 0.03 to 0.00… Show more
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