2002
DOI: 10.1161/hc0102.101388
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Abstract: Background-Homocysteine is a risk factor for coronary artery disease (CAD), although a causal relation remains to be proven. The importance of determining direct causality rests in the fact that plasma homocysteine can be safely and inexpensively reduced by 25% with folic acid. This reduction is maximally achieved by doses of 0.4 mg/d. High-dose folic acid (5 mg/d) improves endothelial function in CAD, although the mechanism is controversial. It has been proposed that improvement occurs through reduction in to… Show more

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Cited by 265 publications
(125 citation statements)
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“…FA has also been shown to improve endothelial function without lowering Hcy, suggesting an alternative explanation for the effect of FA on endothelial function. FA improves endothelial function in coronary artery disease via mechanisms largely independent of Hcy lowering [42]. …”
Section: Role Of Fa and B Vitamins In Cvdmentioning
confidence: 99%
“…FA has also been shown to improve endothelial function without lowering Hcy, suggesting an alternative explanation for the effect of FA on endothelial function. FA improves endothelial function in coronary artery disease via mechanisms largely independent of Hcy lowering [42]. …”
Section: Role Of Fa and B Vitamins In Cvdmentioning
confidence: 99%
“…[141][142][143][144][145][146][147][148][149] Several studies found that folic acid supplementation improved endothelial function in numerous disease states, including hypercholesterolemia, 150,151 hypertension, 143 diabetes, 152 coronary artery disease, 153,154 and cardiovascular disease. 155 In addition, folic acid has shown benefit in Alzheimer disease and the prevention of colon cancer and neural tube defects.…”
Section: Folic Acidmentioning
confidence: 99%
“…Folsäure führt zu einer Verbesserung der Endothelfunktion bei Patienten mit koronarer Herzerkrankung. Der zugrunde liegende Mechanismus ist nicht vollständig geklärt und scheint unabhängig vom Homocystein zu sein [81,82]. In einer kleinen Studie konnten Bergholm et al zeigen, dass eine 3-monatige Therapie mit Methotrexat die endothelabhängige Vasodilatation bei RA-Patienten verbessert [44].…”
Section: Dmardunclassified