Folic acid, dietary habits, and homocysteine levels in relation to neural tube defects: A case–control study in North India

Deb, Roumi; Arora, Jyoti; Samtani, Ratika; Garg, Gaurav; Saksena, Deepti; Sharma, Noopur; Kalla, A.K.; Saraswathy, Kallur Nava

doi:10.1002/bdr2.1373

Cited by 10 publications

(10 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…High plasma homocysteine levels has been associated with a risk for NTDs occurrence (Peker et al., 2016). Plasma homocysteine levels were found to be significantly higher in mothers of NTD offspring compared with mothers of healthy offspring (Aydin et al., 2016; Deb et al., 2018; Deshmukh et al., 2013; Gu et al., 2012; Nasri et al., 2015). In these studies, homocysteine levels were only measured in the mothers, so it is unknown whether homocysteine levels were also higher in infants with NTDs compared with healthy infants (Gu et al., 2012; Nasri et al., 2015).…”

Section: Resultsmentioning

confidence: 99%

The role of Vitamin B12 and genetic risk factors in the etiology of neural tube defects: A systematic review

Wahbeh

Manyama

2021

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

Neural tube defects (NTDs) are birth defects that arise during embryogenesis when normal neural tube closure fails to occur. According to the World Health Organization, NTDs are detected annually in approximately 300,000 neonates worldwide. The exact etiology of NTDs remains complex and poorly understood. It is generally agreed that most NTD cases are of multifactorial origin, having a combination of multiple genes and a number of environmental risk factors. The role of folic acid, vitamin B12 deficiency, genetics and other risk factors, in the etiology of NTDs, has also been extensively studied. This knowledge synthesis brings together different types of evidence to update the role of vitamin B12 deficiency, genetics and other risk factors, in the etiology of NTDs. Following a PubMed search and screening for relevant articles, we included 40 studies in our review (30 case–control studies, 3 cross‐sectional studies, 5 cohort studies, and 2 case reports). The available data showed that vitamin B12 levels were decreased in mothers and infants in NTD groups compared with control groups. Holo‐transcobalamin, the active form of vitamin B12, was also found in lower levels in mothers with NTD‐affected infants. Several studies reported elevated homocysteine levels in mothers and infants in NTD groups. Additionally, numerous studies reported links between genetic variants and increased NTD risk. These genes include GIF, LRP2, CUBN, TCb1R, MTHFR, and others. Several maternal factors have also been linked with significant NTD risk such as BMI, maternal diet, air pollutants, low maternal age, and many others. The majority of studies on NTDs have focused on the role of folic acid, hence there is a need for well‐designed studies on the role of other risk factors like vitamin B12 deficiency in the etiology of NTDs.

show abstract

Section: Resultsmentioning

confidence: 99%

The role of Vitamin B12 and genetic risk factors in the etiology of neural tube defects: A systematic review

Wahbeh

Manyama

2021

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

show abstract

“…Deb et al [62] observed that mean Hcy levels were elevated in cases (15.71 ± 8.35 µmol/L) of NTD births compared to controls (12.87 ± 5.95 µmol/L) but were lower among the non-vegetarians (13.55 ± 6.64 µmol/L) than the vegetarians (14.78 ± 7.93 µmol/L). Due to low intake of vitamin B12, vegetarianism increased the risk of NTDs 1.6-fold (95% CI = 1.0-2.7), while folic acid supplementation demonstrated a protective effect for conceptions (OR = 0.59; 95% CI = 0.3-0.9).…”

Section: Pregnancymentioning

confidence: 98%

Homocysteine: Its Possible Emerging Role in At-Risk Population Groups

Azzini

Ruggeri

Polito

2020

IJMS

105

View full text Add to dashboard Cite

Increased plasma homocysteine is a risk factor for several pathological disorders. The present review focused on the role of homocysteine (Hcy) in different population groups, especially in risk conditions (pregnancy, infancy, old age), and on its relevance as a marker or etiological factor of the diseases in these age groups, focusing on the nutritional treatment of elevated Hcy levels. In pregnancy, Hcy levels were investigated in relation to the increased risk of adverse pregnancy outcomes such as small size for gestational age at birth, preeclampsia, recurrent abortions, low birth weight, or intrauterine growth restriction. In pediatric populations, Hcy levels are important not only for cardiovascular disease, obesity, and renal disease, but the most interesting evidence concerns study of elevated levels of Hcy in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Finally, a focus on the principal pathologies of the elderly (cardiovascular and neurodegenerative disease, osteoporosis and physical function) is presented. The metabolism of Hcy is influenced by B vitamins, and Hcy-lowering vitamin treatments have been proposed. However, clinical trials have not reached a consensus about the effectiveness of vitamin supplementation on the reduction of Hcy levels and improvement of pathological condition, especially in elderly patients with overt pathologies, suggesting that other dietary and non-dietary factors are involved in high Hcy levels. The importance of novel experimental designs focusing on intra-individual variability as a complement to the typical case–control experimental designs and the study of interactions between different factors it should be emphasized.

show abstract

“…Five hundred and ninety‐six studies were retrieved by electronic database search. Out of which 33 studies were assessed the level of homocysteine in NTD mothers (Figure 1) (Afman, Blom, Van der Put, & Van Straaten, 2003; Arbour et al, 2002; Aydin et al, 2016; Cadenas‐Benitez et al, 2014; Candito et al, 2008; Ceyhan et al, 2010; Christensen et al, 1999; Deb et al, 2018; Félix, Leistner, & Giugliani, 2004; Gaber, Farag, Soliman, El‐Bassyouni, & El‐Kamah, 2007; Godbole et al, 2011; Groenen et al, 2004; Gu, Li, Cui, & Luo, 2012; Guo et al, 2013; Gupta et al, 2018; Lacasaña et al, 2012; Lucock, Daskalakis, Lumb, Schorah, & Levene, 1998; Martín et al, 2004; Mills et al, 1995; Mobasheri, Keshtkar, & Golalipour, 2010; Paul, Sadhukhan, Munian, Bankura, & Das, 2018; Peker et al, 2016; Ratan et al, 2008; Shaw et al, 2009; Steegers‐Theunissen et al, 1994, 1995; Ubbink et al, 1999; Wang et al, 2008, 2010, 2013; Yildiz et al, 2016; Zhang et al, 2008; Zhao et al, 2006). Arbour et al (2002) reported two different populations (Cree and non‐Cree) we treated them as separate studies so finally for homocysteine we have 34 studies (2,109 cases and 3,514 controls).…”

Section: Resultsmentioning

confidence: 99%

“…Figure 1)(Afman, Blom, Van der Put, & Van Straaten, 2003;Arbour et al, 2002;Aydin et al, 2016;Cadenas-Benitez et al, 2014;Candito et al, 2008;Ceyhan et al, 2010;Christensen et al, 1999;Deb et al, 2018;Félix, Leistner, & Giugliani, 2004;Gaber, Farag, Soliman, El-Bassyouni, & El- Kamah, 2007;Godbole et al, 2011;Groenen et al, 2004;Gu, Li, Cui, & Luo, 2012;Guo et al, 2013;Gupta et al, 2018; …”

unclassified

Maternal biomarkers for early prediction of the neural tube defects pregnancies

Yadav

Kumar

Rai

2020

Birth Defects Research

View full text Add to dashboard Cite

Background: Neural tube defects (NTD) are one of the most common congenital birth defects. The reason for the NTD cause is still not completely known, but it is believed that some genetic and environmental factors might play a role in its etiology. Among the genetic factors the polymorphism in the folate gene pathway is crucial. Numerous studies have suggested the possible role of maternal higher plasma concentration of homocysteine and low concentration of folate and cobalamin in the development of NTD but some negative studies are also published. Aim: Aim of the present was to find out the exact relation between NTD and maternal biomarkers like folate, cobalamin and homocysteine by conducting a meta-analysis. Method: Different electronic databases were searched for the eligible studies. Standardized mean difference (SMD) with 95% confidence interval (CI) was used to determine association between maternal markers as risk for NTD pregnancy. The p value <0.05 was considered statistically significant in all tests. All the statistical analyses were done in the Open Meta-Analyst program. Results: The homocysteine is significantly associated with the increased risk of NTD (SMD = 0.57; 95% CI: 0.35−0.80, p = <0.001; I2 = 93.01%), s-folate showed protective role in NTD (SMD = −0.48; 95% CI: −0.77 to −0.19, p = 0.001; I2 = 95.73%), similarly cobalamin is also having protective role (SMD = −0.28; 95% CI: −0.43 to −0.13, p = <0.001; I2 = 80.40%). Conclusion: In conclusion this study suggest that different maternal biomarkers may be used for the early prediction of the NTDs.

show abstract

Folic acid, dietary habits, and homocysteine levels in relation to neural tube defects: A case–control study in North India

Cited by 10 publications

References 16 publications

The role of Vitamin B12 and genetic risk factors in the etiology of neural tube defects: A systematic review

The role of Vitamin B12 and genetic risk factors in the etiology of neural tube defects: A systematic review

Homocysteine: Its Possible Emerging Role in At-Risk Population Groups

Maternal biomarkers for early prediction of the neural tube defects pregnancies

Contact Info

Product

Resources

About