Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis

Effect of folic or folinic acid supplementation on methotrexate-associated safety and efficacy in inflammatory disease: a systematic review

“…We also found a meta‐analysis performed by Ortiz et al. and published in the Cochrane databases, 4,5 and two reviews on the topic of folic or folinic acid supplementation 20,21 …”

Effect of folic or folinic acid supplementation on methotrexate-associated safety and efficacy in inflammatory disease: a systematic review

“…We also found a meta‐analysis performed by Ortiz et al. and published in the Cochrane databases, 4,5 and two reviews on the topic of folic or folinic acid supplementation 20,21 …”

Methotrexate Inhibits T Cell Proliferation but Not Inflammatory Cytokine Expression to Modulate Immunity in People Living With HIV

“…Importantly, because participants in A5314 also received 1mg folic acid daily throughout the study, our data also suggest that this dose of folic acid or its timing is insufficient to rescue the anti-proliferative effect of LDMTX in vivo in persons with HIV. Neither folic acid nor folinic acid supplementation reverses the anti-inflammatory effects of LDMTX in people with RA, except when given very proximate to the MTX dose (28)(29)(30)(31)(32)(33)(34)(35). Whether our findings are specific to PWH who maintain robust levels of cycling T cells or is more generalizable is an open question, as is a better understanding of the mechanisms that drive T cell cycling in PWH (36,37).…”

Temporomandibular joint involvement in rheumatoid arthritis, systemic lupus erythematosus and systemic sclerosis

“…Methotrexate appears to be related with the highest incidence of stomatitis, but the presentations of low-dose regimens used in rheumatology are considerably less florid than adverse effects of methotrexate at high chemotherapeutic doses. Ten of the 57 patients using methotrexate in our study were also receiving folate supplementation, which is reported to reduce mucosal methotrexate toxicity 22 . According to Kalantzis et al 23 DMARD therapy may not be the primary a etiological factor in some oral lesions, but it may be a secondary factor preventing healing in lesions such as traumatic ulcers, ulcerated lichenoid drug reactions, or infections.…”

Effect of folic or folinic acid supplementation on methotrexate-associated safety and efficacy in inflammatory disease: a systematic review

“…We also found a meta‐analysis performed by Ortiz et al. and published in the Cochrane databases, 4,5 and two reviews on the topic of folic or folinic acid supplementation 20,21 …”

Methotrexate Inhibits T Cell Proliferation but Not Inflammatory Cytokine Expression to Modulate Immunity in People Living With HIV

“…Importantly, because participants in A5314 also received 1mg folic acid daily throughout the study, our data also suggest that this dose of folic acid or its timing is insufficient to rescue the anti-proliferative effect of LDMTX in vivo in persons with HIV. Neither folic acid nor folinic acid supplementation reverses the anti-inflammatory effects of LDMTX in people with RA, except when given very proximate to the MTX dose (28)(29)(30)(31)(32)(33)(34)(35). Whether our findings are specific to PWH who maintain robust levels of cycling T cells or is more generalizable is an open question, as is a better understanding of the mechanisms that drive T cell cycling in PWH (36,37).…”

Temporomandibular joint involvement in rheumatoid arthritis, systemic lupus erythematosus and systemic sclerosis

“…Methotrexate appears to be related with the highest incidence of stomatitis, but the presentations of low-dose regimens used in rheumatology are considerably less florid than adverse effects of methotrexate at high chemotherapeutic doses. Ten of the 57 patients using methotrexate in our study were also receiving folate supplementation, which is reported to reduce mucosal methotrexate toxicity 22 . According to Kalantzis et al 23 DMARD therapy may not be the primary a etiological factor in some oral lesions, but it may be a secondary factor preventing healing in lesions such as traumatic ulcers, ulcerated lichenoid drug reactions, or infections.…”

Effect of folic or folinic acid supplementation on methotrexate-associated safety and efficacy in inflammatory disease: a systematic review

“…We also found a meta‐analysis performed by Ortiz et al. and published in the Cochrane databases, 4,5 and two reviews on the topic of folic or folinic acid supplementation 20,21 …”

Methotrexate Inhibits T Cell Proliferation but Not Inflammatory Cytokine Expression to Modulate Immunity in People Living With HIV

“…Importantly, because participants in A5314 also received 1mg folic acid daily throughout the study, our data also suggest that this dose of folic acid or its timing is insufficient to rescue the anti-proliferative effect of LDMTX in vivo in persons with HIV. Neither folic acid nor folinic acid supplementation reverses the anti-inflammatory effects of LDMTX in people with RA, except when given very proximate to the MTX dose (28)(29)(30)(31)(32)(33)(34)(35). Whether our findings are specific to PWH who maintain robust levels of cycling T cells or is more generalizable is an open question, as is a better understanding of the mechanisms that drive T cell cycling in PWH (36,37).…”

Temporomandibular joint involvement in rheumatoid arthritis, systemic lupus erythematosus and systemic sclerosis

“…Methotrexate appears to be related with the highest incidence of stomatitis, but the presentations of low-dose regimens used in rheumatology are considerably less florid than adverse effects of methotrexate at high chemotherapeutic doses. Ten of the 57 patients using methotrexate in our study were also receiving folate supplementation, which is reported to reduce mucosal methotrexate toxicity 22 . According to Kalantzis et al 23 DMARD therapy may not be the primary a etiological factor in some oral lesions, but it may be a secondary factor preventing healing in lesions such as traumatic ulcers, ulcerated lichenoid drug reactions, or infections.…”