1979
DOI: 10.1001/archderm.115.8.978
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Folded skin associated with underlying nevus lipomatosus

Abstract: A mentally retarded female infant had abnormalities of the feet, hemiplegia, and an underlying nevus lipomatosus. To our knowledge, this represents the second reported case of marked folding of the skin; with an underlying nevus lipomatosus; this case demonstrated an association of this cutaneous disorder with multiple defects, including chromosomal abnormalities, which have not been previously reported.

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Cited by 16 publications
(11 citation statements)
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“…The currently accepted one is that NLCS develops from messenchymal perivascular cells present first as primitive lipoblasts that subsequently transform into mature lipocytes (5,8,(10)(11)(12). There is no evidence that the deposition of adipose tissue is secondary to degenerative changes in dermal collagen or elastic tissue as Zurhelle and Hoffman originally stated (13), and Nikolowsky also noted and agreed (14). Another theory is that the fat cells represent a true nevus that results from focal heterotopic development of adipose tissue (7).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The currently accepted one is that NLCS develops from messenchymal perivascular cells present first as primitive lipoblasts that subsequently transform into mature lipocytes (5,8,(10)(11)(12). There is no evidence that the deposition of adipose tissue is secondary to degenerative changes in dermal collagen or elastic tissue as Zurhelle and Hoffman originally stated (13), and Nikolowsky also noted and agreed (14). Another theory is that the fat cells represent a true nevus that results from focal heterotopic development of adipose tissue (7).…”
Section: Discussionmentioning
confidence: 99%
“…Finley and Musso point out that the buttock is a site offat storage, but this alone does not explain this peculiar localization in man (8). Nikolowsky points out that the peculiar local blood circulation and the intrauterine pressure on this region may contribute to this predilection (14). Holtz (11) postulates that there would be a "lipophilic" zone in this area, with the thick adipose tissue probably facilitating lipodystrophies.…”
Section: Discussionmentioning
confidence: 99%
“…In a case of circumscribed folded skin with underlying ‘nevus lipomatosus’ the associated anomalies of internal organs were quite different [3]. On the other hand, nevus psiloliparus differs clinically from the lipomatous tissue resulting in generalized folded skin [17, 18].…”
Section: Nevus Psiloliparus Versus Nevus Lipomatosus Underlying Foldementioning
confidence: 99%
“…However, from a clinical point of view it is our impression that this is not the only type of fatty tissue nevus. For example, Gardner et al [3] have documented an unusual nevus lipomatosus giving rise to the peculiar phenomenon of folded skin. Here we describe another distinct disorder for which we propose the term ‘nevus psiloliparus’.…”
Section: Introductionmentioning
confidence: 99%
“…[4] Paracentric inversion of long arm of chromosome 11[5] and deletion of short arm of chromosome 7[6] has been reported in association with MTBS. As noticed in our case, older family members may have remnants of the skin folds.…”
mentioning
confidence: 99%