Folate monoglutamate in cereal grains: Evaluation of extraction techniques and determination by LC-MS/MS

Mehmood, Shahid; Lian, Tong; Wan, Xing; Ling, Jiang; Han, Lida; Zhang, Chunyi; Liang, Qiuju

doi:10.1016/j.jfca.2020.103510

Cited by 17 publications

(9 citation statements)

References 32 publications

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“…Many food matrices have been reported to be rich in MeFox, which is the main oxidation product of 5-CH 3 -H 4 folate. 51,52 However, MeFox does not have bioactivity. PGA, which has been reported to be the most stable folate, could also suffer from losses in some food matrices during the intestinal phase.…”

Section: Hypothesised Pathway Of Folate Interconversion and Degradati...mentioning

confidence: 99%

The bioaccessibility of folate in breads and the stability of folate vitamers duringin vitrodigestion

et al. 2022

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Section: Hypothesised Pathway Of Folate Interconversion and Degradati...mentioning

confidence: 99%

The bioaccessibility of folate in breads and the stability of folate vitamers duringin vitrodigestion

et al. 2022

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“…In maodou, 5MTHF and 5FTHF accounted for 76.40% and 16.70% of total folate content, respectively. Comparatively, the total folate content of maodou was 10–20-fold higher than the folate content in staple crops (rice, maize, and wheat) ( 34 ) and other legumes, including pea (17-fold), common bean (2–3-fold), and lentils (3-fold) ( 35 ). To the best of our knowledge, this is the first study on the profile of the folate content of maodou.…”

Section: Discussionmentioning

confidence: 99%

The nutritional composition of the vegetable soybean (maodou) and its potential in combatting malnutrition

Agyenim-Boateng

Zhang

et al. 2023

Front. Nutr.

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IntroductionGlobal malnutrition continues to be a canker owing to poor eating habits and over-reliance on the major staple crops. Vegetable soybean (maodou) is gaining popularity globally as an affordable snack and vegetable.MethodsIn this study, we profiled the nutritional composition of 12 soybean cultivars at the vegetable (R6-R7) and mature (R8) stages. We also conducted an RNA-seq analysis during seed development, focusing on key biosynthesis enzymes for quality traits.ResultsThe results showed that 100 g of maodou contained 66.54% moisture, 13.49% protein, 7.81% fatty acids, 2.47% soluble sugar, abundant content of minerals, and micronutrients, including folate (462.27 μg FW) and carotenoids (3,935.41 μg FW). Also, the isoflavone content of maodou ranged between 129.26 and 2,359.35 μg/g FW. With regard to the recommended daily allowance, 100 g fresh weight of maodou can contribute 26.98, 115.57, and 11.60% of protein, folate, and zinc, respectively, and significant proportions of other nutrients including linoleic acid (21.16%), linolenic acid (42.96%), zinc (11.60%), and iron (18.01%). On a dry weight basis, maodou has two to six folds higher contents of folate, tocopherol, and carotenoid than the mature soybean. Furthermore, RNA-seq analysis revealed that key biosynthesis enzymes of quality traits are differentially expressed during seed development and may contribute to variations in the content of quality traits at the vegetable and mature stages. Correlation analysis of quality traits at both stages revealed that protein only correlated positively with zinc at the vegetable stage but negatively correlated with total tocopherol and total fatty acid at the mature stage. Complex associations among folates, soluble sugar, and isoflavones were also identified.DiscussionThis study provides insight into the nutritional contents of vegetable soybean and demonstrates that maodou is essential for meeting the nutritional requirements of most countries.

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“…The mixture was boiled for 1 h, then exposed to direct sunlight to degrade endogenous folates. Ten percent activated charcoal was added to the supernatant and was incubated with shaking for 1 h, and then centrifuged at 13,000 rpm for 30 min at 4 • C. The supernatant was filtered through 3KDa MWCO ultra-filtration tubes (29).…”

Section: Methods Validationmentioning

confidence: 99%

Foxtail millet [Setaria italica (L.) P. Beauv.] grown under nitrogen deficiency exhibits a lower folate contents

et al. 2023

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Foxtail millet [Setaria italica (L.) P. Beauv.], as a rich source of folates, has been cultivated on arid infertile lands, for which N deficiency is one of the major issues. Growing environments might have a significant influence on cereal folate levels. However, little is known whether N deficiency modulates cereal folate levels. In order to obtain enriched folate foxtail millet production in nutrient-poor soil, we conducted a study investigating the content of folate derivatives of 29 diverse foxtail millet cultivars under two N regimes (0 and 150 kg N ha−1) for 2 years to explore folate potential grown under low N. The contents of total folate and most derivatives were reduced by N deficiency. The effect on total folate content caused by N was stronger than cultivar genotype did. Folate content of enriched folate cultivars was prone to be reduced by N deficiency. Structural equation models (SEMs) revealed that N fertilization had a positive indirect effect on grain folate content through influencing plant N and K accumulation. Collectively, the results indicate much more attention should be paid to N management when foxtail millet is cultivated in infertile soil, to improve foxtail millet folate contents.

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Folate monoglutamate in cereal grains: Evaluation of extraction techniques and determination by LC-MS/MS

Cited by 17 publications

References 32 publications

The bioaccessibility of folate in breads and the stability of folate vitamers duringin vitrodigestion

The bioaccessibility of folate in breads and the stability of folate vitamers duringin vitrodigestion

The nutritional composition of the vegetable soybean (maodou) and its potential in combatting malnutrition

Foxtail millet [Setaria italica (L.) P. Beauv.] grown under nitrogen deficiency exhibits a lower folate contents

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