2001
DOI: 10.1161/hq0701.092000
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Abstract: Abstract-Homocysteine is a risk factor for coronary artery disease (CAD). Folic acid lowers homocysteine and may improve endothelial function in CAD, although the mechanism is unclear. We investigated the effect of folic acid on endothelial function, homocysteine, and oxidative stress in patients with CAD. We also examined the acute effect of 5-methyltetrahydrofolate (5-MTHF), the principal circulating folate, on endothelial function in vivo and on intracellular superoxide in cultured endothelial cells. A rand… Show more

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Cited by 217 publications
(64 citation statements)
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“…Although Doshi et al reported that folic acid reduces intracellular endothelial superoxide (Doshi et al 2001) and Nakano et al reported folic acid protects against oxidative modification of human LDL (Nakano et al 2001), we could not find any clear results with folic acid supplementation on hsCRP. Although there was a significant decrease in the hsCRP level in the folic acid group at 3 months (paired t test, P = 0.041) compared with the baseline level, the changes from baseline in the folic acid group and those in the placebo group were not different significantly (data not shown).…”
Section: Discussioncontrasting
confidence: 77%
“…Although Doshi et al reported that folic acid reduces intracellular endothelial superoxide (Doshi et al 2001) and Nakano et al reported folic acid protects against oxidative modification of human LDL (Nakano et al 2001), we could not find any clear results with folic acid supplementation on hsCRP. Although there was a significant decrease in the hsCRP level in the folic acid group at 3 months (paired t test, P = 0.041) compared with the baseline level, the changes from baseline in the folic acid group and those in the placebo group were not different significantly (data not shown).…”
Section: Discussioncontrasting
confidence: 77%
“…Hence supplementation with folate alone could to some extent improve endothelial function independently of homocysteine lowering. 19 However in this case, the serum folate at baseline and at 15 months were not different suggesting that other cofactors essential for homocysteine metabolism that we did not measure might be more important.…”
Section: Discussionmentioning
confidence: 60%
“…The molecular basis behind this increased oxidative stress in folate-depleted is not established. Reduced folate such as tetrahydrofolate and 5-methyltetrahydrofolate has been known for its antioxidant ability to scavenge free radicals in vitro (Rezk et al, 2003) and to alleviate oxidative stress in vivo (Doshi et al, 2001;Coppola et al, 2005). Folate was reported to interact with nitric oxide synthase, improve quinonoid BH4 availability and reduce superoxide production (Doshi et al, 2001;Stroes et al, 2006).…”
Section: Discussionmentioning
confidence: 99%
“…Reduced folate such as tetrahydrofolate and 5-methyltetrahydrofolate has been known for its antioxidant ability to scavenge free radicals in vitro (Rezk et al, 2003) and to alleviate oxidative stress in vivo (Doshi et al, 2001;Coppola et al, 2005). Folate was reported to interact with nitric oxide synthase, improve quinonoid BH4 availability and reduce superoxide production (Doshi et al, 2001;Stroes et al, 2006). The present study showed that after administration of folic acid mitochondrial antioxidant level was reduced which indicates that formation of tetrahydrofolate and 5 -methyl tetrafolate after administration of folic acid by 1st pass metabolism.…”
Section: Discussionmentioning
confidence: 99%