Folate and vitamin B<sub>12</sub>: friendly or enemy nutrients for the elderly

Cuskelly, Geraldine; Mooney, Kathleen M.; Young, Ian S.

doi:10.1017/s0029665107005873

Cited by 62 publications

(48 citation statements)

References 70 publications

(102 reference statements)

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“…In addition, FA fortification has been found to be a cause of masking vitamin B 12 deficiency, particularly in the elderly population (16) . However, diet by itself does not appear to provide pregnant women with sufficient amounts of folate to prevent major birth defects.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with a positive intake of folic acid in the periconceptional period among Korean women

Kim

Han

Cho

et al. 2008

PHN

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Objective: We aimed to investigate the factors associated with a positive intake of folic acid (FA) during the periconceptional period among Korean women. Design: In a cross-sectional study of demographic, obstetric and socio-economic data, history of periconceptional intake of FA and awareness of the benefits of FA supplementation in pregnancy were obtained and analysed using the x 2 test, followed by multiple logistic regression analysis. Setting: The Maternity School, Cheil General Hospital and Women's Healthcare Center, Seoul, South Korea, between October 2005 and March 2006. Subjects: In total 1313 pregnant women participating in a two-day training course available every month. Results: After excluding subjects with incomplete or inconsistent data, there were 1277 women included in the analysis. Participants were aged 29?4 (SD 2?9) years and had a mean gestational age of 27?9 (SD 7?1) weeks. Only 131 (10?3 %) women took FA during the periconceptional period. According to multiple logistic regression analyses, the adjusted OR for FA supplementation was 1?79 (95 % CI 1?10, 2?91) in women who had previous spontaneous abortions, 4?10 (95 % CI 2?43, 6?78) in women who planned their pregnancy and 6?63 (95 % CI 2?08, 21?12) in those who were aware of the protective effects of FA. Conclusions: Periconceptional intake of FA was more likely among Korean women with a history of previous spontaneous abortion, who planned their pregnancy or who were aware of the protective effects of FA during pregnancy. However, the proportion of women who took FA in the periconceptional period was low.

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Section: Discussionmentioning

confidence: 99%

Factors associated with a positive intake of folic acid in the periconceptional period among Korean women

Kim

Han

Cho

et al. 2008

PHN

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“…Even when macrocytosis is considered during diagnosis, increased mean cell volume (MCV) values are, in most cases, related to other conditions such as drug and alcohol abuse. Furthermore, cobalamin and folate deficiencies have been shown to be responsible for macrocytosis in only 6 % of the cases (3) . Cobalamin deficiency may be caused by pernicious anaemia, which is an autoimmune disease characterized by gastric mucosa destruction through a primarily cell-mediated process (4) .…”

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confidence: 99%

“…Cobalamin deficiency may be caused by pernicious anaemia, which is an autoimmune disease characterized by gastric mucosa destruction through a primarily cell-mediated process (4) . The factors that contribute to the malabsorption of food cobalamin include chronic presence of Helicobacter pylori, achlorhydria and intestinal microbial proliferation, which can be brought on by antibiotic treatment (3,5) . In patients with pernicious anaemia, studies of methylmalonic acid (MMA) and homocysteine values compared with vitamin B 12 levels have determined that metabolites are elevated prior to the development of any clinical abnormalities and often prior to abnormal serum vitamin B 12 concentrations (6) .…”

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confidence: 99%

“…Importantly, the stage at which neurological damage first appears during decreasing vitamin B 12 status is not yet clear. Therefore, exactly when vitamin B 12 deficiency becomes clinically important, or, alternatively, when the damage caused by this deficiency first occurs, has not yet been established (3) . There are few studies regarding vitamin B 12 deficiency in developing countries.…”

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confidence: 99%

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High frequency of vitamin B₁₂ deficiency in a Brazilian population

Xavier

Costa

Annichino‐Bizzacchi

et al. 2010

Public Health Nutr.

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Objective: There are few studies regarding vitamin B 12 deficiency in developing countries. In Brazil, a late diagnosis of vitamin B 12 deficiency progressing to severe neurological damage is common. Thus, the aim of the present study was to verify the frequency of vitamin B 12 deficiency in two Brazilian populations (elderly and adult participants) and to compare different methods of vitamin B 12 deficiency detection. Design: Five hundred participants were recruited from health centres from south-east Brazil and were separated into two groups: 60 years old or more and 30-59 years old. Vitamin B 12 and folate concentrations were measured using electrochemiluminescence immunoassay (ECI) and RIA. Methylmalonic acid (MMA) was measured by LC coupled to tandem MS. Full blood counts were acquired using standard methods. Results: All participants had normal blood count results and mean cell volume less than 99 fl; none of them presented folate deficiency according to the results, which were all greater than 3 ng/ml. Cobalamin levels less than 200 pmol/l were identified by one of the two or by both methods in 7?2 % of the participants aged 60 years or more and 6?4 % of the participants aged 30-59 years. MMA levels were higher in older subjects (P 5 0?007) compared with younger subjects. A greater correlation of MMA v. RIA was observed than of MMA v. ECI (P 5 0?0017 v. P 5 0?014). MMA quantification estimated that cobalamin deficiency was present in more than 11 % of the subjects for both studied groups. Conclusions: The study shows that vitamin B 12 deficiency is frequent in Brazilian adults and suggests that RIA is more sensitive than ECl for measuring cobalamin levels.

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“…This is generally not an issue for women of reproductive age but becomes a concern for those older than 65 years. 30 In addition, a slightly increased risk of wheeze and respiratory tract infections was found in offspring whose mothers took folic acid supplements during pregnancy. 31 Yajnik et al 32 reported that children whose mothers had high folate and low vitamin B12 levels during pregnancy had the highest risk of insulin-resistance, compared with those whose mothers who only had low B12 or high folate (but both of those groups had higher levels than did those whose mothers had normal B12 and folate).…”

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confidence: 99%

Policy statement on folic acid and neural tube defects

Toriello

2011

Genetics in Medicine

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Disclaimer: ACMG standards and guidelines are designed primarily as an educational resource for medical geneticists and other healthcare providers to help them provide quality medical genetic services. Adherence to these standards and guidelines does not necessarily ensure a successful medical outcome. These standards and guidelines should not be considered inclusive of all proper procedures and tests or exclusive of other procedures and tests that are reasonably directed to obtaining the same results. In determining the propriety of any specific procedure or test, the geneticists should apply their own professional judgment to the specific clinical circumstances presented by the individual patient or specimen. It may be prudent, however, to document in the patient's record the rationale for any significant deviation from these standards and guidelines.

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Folate and vitamin B₁₂: friendly or enemy nutrients for the elderly

Cited by 62 publications

References 70 publications

Factors associated with a positive intake of folic acid in the periconceptional period among Korean women

Factors associated with a positive intake of folic acid in the periconceptional period among Korean women

High frequency of vitamin B₁₂ deficiency in a Brazilian population

Policy statement on folic acid and neural tube defects

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Folate and vitamin B12: friendly or enemy nutrients for the elderly

Cited by 62 publications

References 70 publications

Factors associated with a positive intake of folic acid in the periconceptional period among Korean women

Factors associated with a positive intake of folic acid in the periconceptional period among Korean women

High frequency of vitamin B12 deficiency in a Brazilian population

Policy statement on folic acid and neural tube defects

Contact Info

Product

Resources

About

Folate and vitamin B₁₂: friendly or enemy nutrients for the elderly

High frequency of vitamin B₁₂ deficiency in a Brazilian population