Focal Segmental Glomerulosclerosis Associating Kimura Disease

Dede, Fatih; Aylı, Deniz; Atilgan, Kadir Gokhan; Yüksel, Ciineyt; Duranay, Murat; Sener, Didem; Türker, Funda

doi:10.1081/jdi-200056593

Cited by 9 publications

(10 citation statements)

References 8 publications

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“…Nephrotic syndrome has been reported as a complication of Kimura's disease, including membranous nephropathy, minimal change disease, diffuse proliferative glomerulonephritis, mesangial proliferative glomerulonephritis and membrane proliferative glomerulonephritis [8], with a few FSGS cases [9][10][11]. Steroid monotherapy has been used for Kimura's disease and FSGS with varying degrees of success [9][10][11][12]. In this case, the patient was steroid-sensitive on remission of eosinophils, eosinophilic peritonitis, lymph nodes and partial remission of renal damage, which was clinically considered to be associated with systematic involvement of Kimura's disease, however without stronger evidence, and needs long-term follow-up.…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic peritonitis and nephrotic syndrome in Kimura’s disease: a case report and literature review

Yang

Song

et al. 2020

BMC Nephrol

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Background: Eosinophilic peritonitis is a relatively rare entity. Kimura's disease is a rare chronic inflammatory disorder of unknown etiology, characterized by subcutaneous nodules mainly in the head and neck region, regional lymphadenopathy and occasional involvement of kidney. There is currently no report of eosinophilic peritonitis in Kimura's disease. Case presentation: A 44-year-old Chinese man presented with abdominal distention, nausea, vomiting and edema in lower limbs for 1 month. Laboratory data showed elevated eosinophils in peripheral blood and ascites, nephrotic syndrome with progressively renal dysfunction, and elevated IgE. Ultrasonography of lymph nodes showed multiple lymphadenopathy in bilateral inguinal regions. Surgical excision was performed for one of the enlarged lymph nodes and histopathology revealed diagnosis of Kimura's disease. Renal biopsy indicated focal segmental glomerulosclerosis (FSGS) and acute tubulointerstitial nephritis with infiltration of eosinophils in renal interstitium. The patient was prescribed with oral prednisolone therapy (30 mg/day), and underwent continuous ambulatory peritoneal dialysis (CAPD). The peripheral and peritoneal eosinophil count decreased rapidly and normalized within 2 days. Forty-five days after prednisolone therapy, partial remission of nephrotic syndrome and decrease of serum creatinine were achieved while peritoneal dialysis dosage had decreased. Inguinal lymph nodes gradually shrunk in size. The overall conditions remain stable afterwards. Conclusions: This rare case highlighted the clinical conundrum of a patient presenting with eosinophilic peritonitis, lymphadenopathy, nephrotic syndrome and renal failure associated with Kimura's disease. The remarkable eosinophilia, pathology of lymph node and kidney, as well as significant response to steroids should guide towards the diagnosis.

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Section: Discussionmentioning

confidence: 99%

Eosinophilic peritonitis and nephrotic syndrome in Kimura’s disease: a case report and literature review

Yang

Song

et al. 2020

BMC Nephrol

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“…Diabetes mellitus has been found in about 37–40% of patient with AG, and may be caused by injury of elastic fiber from hyperglycemic state [ 12 ]. As for the renal condition, focal segmental glomerulosclerosis has been described in association with various granulomatous diseases (e.g., sarcoidosis, Wegener's granulomatosis, Churg-Strauss syndrome, and Kimura's disease) [ 13 , 14 , 15 , 16 ]. However, the association of AG and focal segmental glomerulosclerosis has never been reported.…”

Section: Discussionmentioning

confidence: 99%

Actinic Granuloma with Focal Segmental Glomerulosclerosis

2016

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Actinic granuloma is an uncommon granulomatous disease, characterized by annular erythematous plaque with central clearing predominately located on sun-damaged skin. The pathogenesis is not well understood, ultraviolet radiation is recognized as precipitating factor. We report a case of a 52-year-old woman who presented with asymptomatic annular erythematous plaques on the forehead and both cheeks persisting for 2 years. The clinical presentation and histopathologic findings support the diagnosis of actinic granuloma. During that period of time, she also developed focal segmental glomerulosclerosis. The association between actinic granuloma and focal segmental glomerulosclerosis needs to be clarified by further studies.

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“…Membranous glomerulopathy is the most common finding, but mesangial proliferative glomerulonephritis, minimal change disease and IgA-nephropathy have been reported as well [ 4,5 ]. FSGS associated with Kimura’s disease has only been reported six times previously in the literature, but none of them was of African ancestry [ 6,7 ]. FSGS is more common in patients of African ancestry, but the tip lesion as was found in our patient is not typical.…”

Section: Discussionmentioning

confidence: 99%