Focal Segmental Glomerulosclerosis Associated with Pulmonary Sarcoidosis

Peces, R; Torre, Mercedes de la; Fructuoso, Ana Sánchez; Escalada, P.

doi:10.1159/000187591

Cited by 7 publications

(8 citation statements)

References 9 publications

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“…However, the failure of steroid therapy to control sarcoidosis symptoms did not preclude the remission of glomerular disease in three patients (pt1, pt 3 and pt6). These observations are different from those of existing case reports, in which glomerular disease activity appeared to be influenced by the response of the sarcoidosis to steroid therapy [17,20,24,52]. Altogether, these observations show that the steroid responsiveness of sarcoidosis does not correlate with that of glomerular disease and suggest that both diseases require possibly a more aggressive therapy.…”

Section: Discussioncontrasting

confidence: 98%

“…Most publications reporting glomerular diseases in the context of sarcoidosis consisted exclusively in case reports. The nature of glomerular lesions seems to be diverse, with membranous nephropathy (MN) [10-14]; minimal change nephrotic syndrome (MCNS) [15-17]; focal segmental glomerulosclerosis (FSGS) [18-20], imunoglobulin A nephropathy (IgAN) [21-24] and proliferative glomerulonephritis [13,25,26]. …”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological study of glomerular diseases associated with sarcoidosis: a multicenter study

Stehlé

Joly

Vanhille

et al. 2013

Orphanet J Rare Dis

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BackgroundThe association between sarcoidosis and glomerular diseases has not been extensively investigated in a large series and the potential features of this uncommon association remain to be determined.MethodsWe retrospectively identified 26 patients with biopsy-proven glomerular lesions that occurred in a sarcoidosis context. Potential remission of glomerular disease and sarcoidosis under specific treatment (steroid and/or immunosuppressive agents) was recorded for all patients. Demographic, clinical and biological characteristics were assessed at the time of kidney biopsy for each patient. Therapeutic data were analyzed for all patients.ResultsGlomerular disease occurred after the diagnosis of sarcoidosis in 11 of 26 cases (42%) (mean delay of 9.7 years). In six patients (23%), the glomerulopathy preceded the sarcoidosis diagnosis (mean delay 8 years). In the last nine patients (35%), both conditions occurred simultaneously. The most frequent glomerular disease occurring in sarcoidosis patients was membranous nephropathy in eleven cases. Other glomerular lesions included IgA nephropathy in six cases, focal segmental glomerulosclerosis in four patients, minimal change nephrotic syndrome for three patients and proliferative lupus nephritis in two patients. Granulomatous interstitial nephritis was associated with glomerular disease in six patients and was exclusively found in patients in whom the both disease occurred simultaneously. In nine patients with simultaneous glomerular and sarcoidosis diseases, we observed a strong dissociation between glomerular disease and sarcoidosis in terms of steroid responsiveness. At the end of the follow-up (mean of 8.4 years), six patients had reached end-stage renal disease and three patients had died.ConclusionsA wide spectrum of glomerular lesions is associated with sarcoidosis. The close temporal relationship observed in some patients suggests common causative molecular mechanisms of glomerular injury but complete remission of both diseases in response to exclusive steroid therapy is infrequent.

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Section: Discussioncontrasting

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Clinicopathological study of glomerular diseases associated with sarcoidosis: a multicenter study

Stehlé

Joly

Vanhille

et al. 2013

Orphanet J Rare Dis

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“…Renal manifestation in sarcoidosis commonly involves disordered calcium metabolism, interstitial noncaseating granulomas, and glomerular lesions (6)(7)(8)(9)(10)(11)(12)(13). In the present case, although 1.25-dihydroxyvitamin D was slightly ele-F i g u r e 4 .…”

Section: Sarcoidosis Is a Systemic Disorder Of Unknown Origin Typicamentioning

confidence: 50%

Sarcoidosis Associated with Renal Masses on Computed Tomography

et al. 2006

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“…Therefore, nephrotic syndrome is thought to be mainly due to renal involvement of sarcoidosis. A total of 5 cases of nephrotic syndrome with FSGS associated with sarcoidosis have been reported [5, 6, 7, 8, 9]. One of the cases reported by Peces et al [5]had active pulmonary sarcoidosis and nephrotic syndrome secondary to FSGS.…”

Section: Discussionmentioning

confidence: 99%

A Rare Cause of Focal Segmental Glomerulosclerosis: Sarcoidosis

Altıparmak

Oygar²,

Bilir³

et al. 2002

Nephron

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A 58-year-old female patient diagnosed as having sarcoidosis 23 years ago developed nephrotic syndrome. No pathology was found which could explain this, so it was attributed to her sarcoidosis. Renal biopsy showed global and segmental sclerosis. The occurrence of focal segmentary glomerulosclerosis in a case of sarcoidosis is rare. In systemic sarcoidosis it is thought that T-cell dysfunction may play a role in the pathogenesis of glomerulonephritis. When treatment is considered, corticosteroid therapy may be used according to the clinical status at diagnosis as well as on follow-up of the patient.

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Focal Segmental Glomerulosclerosis Associated with Pulmonary Sarcoidosis

Cited by 7 publications

References 9 publications

Clinicopathological study of glomerular diseases associated with sarcoidosis: a multicenter study

Clinicopathological study of glomerular diseases associated with sarcoidosis: a multicenter study

Sarcoidosis Associated with Renal Masses on Computed Tomography

A Rare Cause of Focal Segmental Glomerulosclerosis: Sarcoidosis

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