FNA in diagnosis of orbital lesions causing proptosis in adults

Singhal, Niti; Mundi, Irneet; Handa, Uma; Punia, Raj Pal Singh; Mohan, Harsh

doi:10.1002/dc.21649

Cited by 8 publications

(6 citation statements)

References 9 publications

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“…It is a valuable procedure for preoperative assessment of the lesions. Various studies have shown the diagnostic accuracy of orbital FNAC range between 72 and 100% (Table ) . A low diagnostic concordance rate was reported, mostly in the initial days of orbital FNAC; whereas more recent and larger studies have shown consistently better results with an overall diagnostic accuracy of 100% .…”

Section: Discussionmentioning

confidence: 99%

Fine‐needle aspiration cytology of orbital and eyelid lesions

Agrawal

Dey

Lal

2013

Diagnostic Cytopathology

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Fine-needle aspiration cytology (FNAC) of orbital lesions is now increasingly popular. Because of its unique location and the occurrence of varieties of lesions, diagnosis of orbital lesion is a challenge to the cytopathologists. FNAC of orbital and eyelid tumors is a suitable diagnostic technique that necessitates close co-operation between the ophthalmologist and pathologist. No radical procedure should be planned on the basis of FNAC, but it allows the diagnosis of a new primary lesion or the recurrence or metastasis of a tumor and can be done to identify lesions that require either specific medical therapy, as in nonresectable, inflammatory, and lymphoid tumors, or limited surgery for benign resectable neoplasms. With the help of various ancillary techniques a definitive diagnosis is possible on orbital and adnexal lesions. It is essential to have a detailed knowledge on the FNAC of these lesions and their potential pitfalls. In this present review, we have discussed various orbital lesions, their clinical presentations, cytomorphology, and ancillary techniques to confirm the diagnosis.

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Section: Discussionmentioning

confidence: 99%

Fine‐needle aspiration cytology of orbital and eyelid lesions

Agrawal

Dey

Lal

2013

Diagnostic Cytopathology

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“…[9101112131516] The main limitations of the procedure include varying sensitivity, nondiagnostic aspirates and possible complications such as retrobulbar haemorrhage, blindness, motility disturbances, ptosis and globe perforation with vitreous haemorrhage. [17] In orbital mass lesions, the diagnostic accuracy of FNAC varies from 23% to 100%, depending on the skill of the operator, size and site of the lesion, and the expertise of the cytopathologist in interpreting the smears.…”

Section: Discussionmentioning

confidence: 99%

Role of fine needle aspiration cytology as a diagnostic tool in orbital and adnexal lesions

Khan

Malukani

Malaiya

et al. 2016

J Ophthalmic Vis Res

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Purpose:To evaluate the role of fine needle aspiration (FNAC) as a diagnostic tool in cases of orbital and ocular adnexal masses. Cytological findings were correlated with histopathological diagnosis wherever possible.Methods:FNAC was performed in 29 patients of different age groups presenting with orbital and ocular adnexal masses. Patients were evaluated clinically and investigated by non-invasive techniques before fine needle aspiration of the masses. Smears were analyzed by a cytologist in all cases. Further, results of cytology were compared with the histopathological diagnosis.Results:The age of patients ranged from 1 to 68 years (mean: 29.79±19.29). There were 14 males and 15 females with a male to female ratio of 0.93:1. Out of 29 cases, 26 aspirates were cellular. Cellularity was insufficient in three (10.34%) aspirates. Out of 26 cellular aspirates, 11 were non-neoplastic while 15 were neoplastic on cytology. Subsequent histopathologic examination was done in 21/26 cases. Concordance rate of FNAC in orbital and ocular adnexal mass lesions with respect to the precise histologic diagnosis was 90%.Conclusion:When properly used in well-indicated patients (in cases where a diagnosis cannot be made by clinical and imaging findings alone), FNAC of orbital and periorbital lesions is an invaluable and suitable adjunct diagnostic technique that necessitates close cooperation between the ophthalmologist and cytologist. However, nondiagnostic aspirates may sometimes be obtained, and an inconclusive FNAC should not always be ignored.

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“…The most important clinical variables are the age of the patient and medical history [3], which can either suggest or exclude certain diagnoses (for example, cystic lymphangiomas are more likely to manifest themselves at a young age; more patients with orbital pseudotumors may have swollen eyelids, conjunctival congestion, pain, retinal folds or hemorrhage and optic nerve atrophy than patients with lymphoid tumors [4]). The first diagnostic step after clinical examination is represented by imaging techniques.…”

Section: Discussionmentioning

confidence: 99%

The Role of Fine Needle Aspiration of Orbital Lesions: A Case Series

Pagni¹,

Jaconi²,

Smith³

et al. 2016

Acta Cytologica

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Objective: This paper analyzes a series of ultrasound (US)-guided orbital fine needle aspirations (FNAs) which provide diagnostic information that cytopathologists approaching orbital lesions for the first time can find useful and underlines the importance of teamwork. Study Design: The investigators retrospectively obtained data from 24 consecutive orbital FNAs. For all patients, a complete clinicoradiological database was created. FNAs were performed under US guidance with 25-gauge needles and an aspiration biopsy syringe gun, and sent to the Department of Pathology for examination and data management. Results: The mean age of the patients was 54 years. Imaging studies included US, magnetic resonance imaging and computed tomography scans; 9 lesions involved the right orbit and 15 the left orbit. The mean lesion size was 23.6 ± 7.2 mm. After microscopic examination, 7 smears were labeled as ‘nondiagnostic', while in 17 cases a definitive diagnosis was proposed, which always proved to be correct (70.8%, specificity = 100%). Conclusions: The investigators believe that FNA biopsy of orbital masses is a necessary step; its weaknesses lie in the particularly delicate site of sampling and the extreme heterogeneity of lesions. Nevertheless, when orbital FNA is performed within a well-coordinated multidisciplinary team, it is a powerful tool that can be used to define the most appropriate management of these patients.

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FNA in diagnosis of orbital lesions causing proptosis in adults

Cited by 8 publications

References 9 publications

Fine‐needle aspiration cytology of orbital and eyelid lesions

Fine‐needle aspiration cytology of orbital and eyelid lesions

Role of fine needle aspiration cytology as a diagnostic tool in orbital and adnexal lesions

The Role of Fine Needle Aspiration of Orbital Lesions: A Case Series

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