Flying spot remote sensing of ICG kinetics of undeformed tissues

Wang, X.; Zhao, Zhongyao; Becker, Wolfgang; Troxler, T.; Chance, Britton

doi:10.1117/12.610991

Cited by 2 publications

(1 citation statement)

References 1 publication

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“…To improve on these shortcomings, NIRS undergoes a transition from a single-point technique employing one or several source-detector pairs towards an optical mapping technique by applying, first of all, large arrays of source-detector pairs [9]. Secondly, two-dimensional (2D) imaging approaches are realized in a variety of different methods, ranging from structured illumination combined with frequency-domain NIRS [10][11][12][13] to flying-spot scanning methods [14]. These imaging approaches have already been applied to a variety of tasks, such as measuring optical properties of different types of phantoms and biological tissue [10,12,15,16].…”

Section: Introductionmentioning

confidence: 99%

Non-contact in vivo diffuse optical imaging using a time-gated scanning system

Mazurenka¹,

Sieno²,

Boso³

et al. 2013

Biomed. Opt. Express

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Abstract:We report on the design and first in vivo tests of a novel noncontact scanning imaging system for time-domain near-infrared spectroscopy. Our system is based on a null source-detector separation approach and utilizes polarization-selective detection and a fast-gated single-photon avalanche diode to record late photons only. The in-vivo tests included the recording of hemodynamics during arm occlusion and two brain activation tasks. Localized and non-localized changes in oxy-and deoxyhemoglobin concentration were detected for motor and cognitive tasks, respectively. The tests demonstrate the feasibility of non-contact imaging of absorption changes in deeper tissues.

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Section: Introductionmentioning

confidence: 99%

Non-contact in vivo diffuse optical imaging using a time-gated scanning system

Mazurenka¹,

Sieno²,

Boso³

et al. 2013

Biomed. Opt. Express

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Non-contact time-resolved diffuse reflectance imaging at null source-detector separation

Mazurenka¹,

Jelzow²,

Wabnitz³

et al. 2011

Opt. Express

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We report results of the proof-of-principle tests of a novel non-contact tissue imaging system. The system utilizes a quasi-null source-detector separation approach for time-domain near-infrared spectroscopy, taking advantage of an innovative state-of-the-art fast-gated single photon counting detector. Measurements on phantoms demonstrate the feasibility of the non-contact approach for the detection of optically absorbing perturbations buried up to a few centimeters beneath the surface of a tissue-like turbid medium. The measured depth sensitivity and spatial resolution of the new system are close to the values predicted by Monte Carlo simulations for the inhomogeneous medium and an ideal fast-gated detector, thus proving the feasibility of the non-contact approach for high density diffuse reflectance measurements on tissue. Potential applications of the system are also discussed.

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Flying spot remote sensing of ICG kinetics of undeformed tissues

Cited by 2 publications

References 1 publication

Non-contact in vivo diffuse optical imaging using a time-gated scanning system

Non-contact in vivo diffuse optical imaging using a time-gated scanning system

Non-contact time-resolved diffuse reflectance imaging at null source-detector separation

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