Fluvoxamine ameliorates oxidative stress and inflammation induced by bile-duct ligation in male rats

Barmoudeh, Zahra; Sadeghi, Hossein; Gheitasi, Izadpanah; Khalvati, Bahman; Omidifar, Navid; Azizi, Mahdokht; Moslemi, Zahra; Nikbakht, Jafar; Doustimotlagh, Amir Hossein

doi:10.1016/j.heliyon.2022.e12344

Cited by 2 publications

(1 citation statement)

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“…In our study, BDL group exhibited an increase in the lipid peroxidation end product, MDA, coupled with a reduction in SOD activity in hepatic tissue. Similar results were reported by Barmoudeh et al 37 . Oxidative stress is a prominent phenomenon in cholestasis that develops from an imbalance between oxidants and antioxidants 38 .…”

Section: Discussionsupporting

confidence: 92%

Diacerein ameliorates cholestasis-induced liver fibrosis in rat via modulating HMGB1/RAGE/NF-κB/JNK pathway and endoplasmic reticulum stress

Abdelfattah

Mahmoud

El-Wafaey

et al. 2023

Sci Rep

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Diacerein is an interleukin (IL)-1β inhibitor approved for osteoarthritis. This study aimed to investigate the potential anti-fibrotic effect of diacerein against bile duct ligation (BDL)-induced liver fibrosis. Forty male Wistar rats were divided into: sham-operated group, BDL group, and BDL groups treated with diacerein at 10, 30, and 50 mg/kg/day starting two days before surgery and continued for 4 weeks. Diacerein decreased the hepatic injury markers and alleviated oxidative stress triggered by BDL by reducing hepatic malondialdehyde (MDA) and increasing hepatic superoxide dismutase (SOD) levels. Diacerein mitigated BDL-induced inflammation via lowering hepatic levels and mRNA expression of high mobility group box 1 (HMGB1), nuclear factor-κB (NF-κB), and IL-1β. The hepatic gene expression of Advanced Glycation End products Receptor (RAGE) gene and immunohistochemical expression of some ER stress markers, e.g., glucose-regulated protein 78 (GRP78), inositol-requiring enzyme 1 (IRE1α), protein kinase RNA-like endoplasmic reticulum kinase (PERK), CCAAT/enhancer-binding protein homologous protein (CHOP), and phosphorylated c-Jun N-terminal kinase protein contents were lowered by diacerein. Furthermore, diacerein suppressed the hepatic levels of fibrogenic mediators, e.g., Transforming growth factor β1 (TGF˗β1), α- smooth muscle actin (α-SMA), collagen 1, and hydroxyproline, as well as the apoptotic caspase 3 and BAX immunostaining in BDL rats. The histopathological abnormalities induced by BDL significantly improved. Our study demonstrated that diacerein exhibited an antifibrotic effect by inhibiting HMGB1/RAGE/NF-κB/JNK pathway, and ER stress. Better protection was observed with increasing the dose.

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Section: Discussionsupporting

confidence: 92%