volume 301, issue 1, PG9-G19 2011
DOI: 10.1152/ajpgi.00267.2010
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Abstract: Although fluoxetine, a selective serotonin reuptake inhibitor, is known to demonstrate antiinflammatory activity, little information is available on the effect of fluoxetine regarding intestinal inflammation. This study investigates the role of fluoxetine in the attenuation of acute murine colitis by suppression of the NF-B pathway in intestinal epithelial cells (IEC). Fluoxetine significantly inhibited activated NF-B signals and the upregulated expression of interleukin-8 (IL-8) in COLO 205 colon epithelial …

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