Infectious Disease Clinics of North America volume 19, issue 3, P617-628 2005 DOI: 10.1016/j.idc.2005.05.005 View full text
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Urs B. Schaad

Abstract: The use of fluoroquinolones in children is limited because of the potential of these agents to induce arthropathy in juvenile animals and to potentiate development of bacterial resistance. No quinolone-induced cartilage toxicity as described in animal experiments has been documented unequivocally in patients, but the risk fro rapid emergence of bacterial resistance associated with widespread, uncontrolled fluoroquinolones use in children is a realistic threat. Overall, the fluoroquinolones have been safe and e…

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