Fluorophotometry

Subtotal pancreatectomy in five different rat strains: Incidence and course of development of diabetes

“…Furthermore, published data indicate possible differences in the susceptibility of various strains of rats to the development diabetes. For example, in male Wistar Albino rats, the incidence of diabetes was reported to be 90% 6 months after subtotal pancreatectomy [3] and 50% after 3 months [4], while in another, not exactly defined strain (hooded rats), all animals became diabetic within 8 days of the operation [5]. This apparent variation led us to investigate the incidence and the course of development of diabetes during 12 months after subtotal pancreatectomy in five strains of rats available to us from our local breeding station.…”

Subtotal pancreatectomy in five different rat strains: Incidence and course of development of diabetes

“…Furthermore, published data indicate possible differences in the susceptibility of various strains of rats to the development diabetes. For example, in male Wistar Albino rats, the incidence of diabetes was reported to be 90% 6 months after subtotal pancreatectomy [3] and 50% after 3 months [4], while in another, not exactly defined strain (hooded rats), all animals became diabetic within 8 days of the operation [5]. This apparent variation led us to investigate the incidence and the course of development of diabetes during 12 months after subtotal pancreatectomy in five strains of rats available to us from our local breeding station.…”

Vitreous fluorescein accumulation determined by in vivo fluorophotometry and by vitreous extraction in normal and diabetic rats

“…Elevated vitreous fluorescein levels [7,8] in diabetic rats which could be normalized by insulin treatment [9,10], as well as no differences between normal and diabetic rats, have been reported [11,12]. Technical difficulties [13,14] in measuring vitreous fluorescein levels in rats and biological factors [11,14] such as metabolic state and strain differences of the animals might have caused these inconsistent data. Parameters which influence the vitreous readings such as plasma fluorescein pharmacokinetics and fluorescein protein binding were also not sufficiently considered [15].…”

Subtotal pancreatectomy in five different rat strains: Incidence and course of development of diabetes

“…Furthermore, published data indicate possible differences in the susceptibility of various strains of rats to the development diabetes. For example, in male Wistar Albino rats, the incidence of diabetes was reported to be 90% 6 months after subtotal pancreatectomy [3] and 50% after 3 months [4], while in another, not exactly defined strain (hooded rats), all animals became diabetic within 8 days of the operation [5]. This apparent variation led us to investigate the incidence and the course of development of diabetes during 12 months after subtotal pancreatectomy in five strains of rats available to us from our local breeding station.…”

Vitreous fluorescein accumulation determined by in vivo fluorophotometry and by vitreous extraction in normal and diabetic rats

“…Elevated vitreous fluorescein levels [7,8] in diabetic rats which could be normalized by insulin treatment [9,10], as well as no differences between normal and diabetic rats, have been reported [11,12]. Technical difficulties [13,14] in measuring vitreous fluorescein levels in rats and biological factors [11,14] such as metabolic state and strain differences of the animals might have caused these inconsistent data. Parameters which influence the vitreous readings such as plasma fluorescein pharmacokinetics and fluorescein protein binding were also not sufficiently considered [15].…”

Subtotal pancreatectomy in five different rat strains: Incidence and course of development of diabetes

“…Furthermore, published data indicate possible differences in the susceptibility of various strains of rats to the development diabetes. For example, in male Wistar Albino rats, the incidence of diabetes was reported to be 90% 6 months after subtotal pancreatectomy [3] and 50% after 3 months [4], while in another, not exactly defined strain (hooded rats), all animals became diabetic within 8 days of the operation [5]. This apparent variation led us to investigate the incidence and the course of development of diabetes during 12 months after subtotal pancreatectomy in five strains of rats available to us from our local breeding station.…”

Vitreous fluorescein accumulation determined by in vivo fluorophotometry and by vitreous extraction in normal and diabetic rats

“…Elevated vitreous fluorescein levels [7,8] in diabetic rats which could be normalized by insulin treatment [9,10], as well as no differences between normal and diabetic rats, have been reported [11,12]. Technical difficulties [13,14] in measuring vitreous fluorescein levels in rats and biological factors [11,14] such as metabolic state and strain differences of the animals might have caused these inconsistent data. Parameters which influence the vitreous readings such as plasma fluorescein pharmacokinetics and fluorescein protein binding were also not sufficiently considered [15].…”