Fluorometric Studies on the Blood-Retinal Barrier in Experimental Animals

Intravitreal triamcinolone as a primary therapy in diabetic macular oedema

“…20 In addition, both clinical observations and studies involving diabetic animal models have implicated breakdown of the outer blood-retinal barrier in the development of diabetic macular oedema. 21,22 Some studies suggest that vitreo-macular traction may play a role in increased retinal vascular permeability. 23,24 So, pars plana vitrectomy has been advocated for the treatment of macular oedema with or without a taut, attached posterior hyaloid.…”

Intravitreal triamcinolone as a primary therapy in diabetic macular oedema

“…20 In addition, both clinical observations and studies involving diabetic animal models have implicated breakdown of the outer blood-retinal barrier in the development of diabetic macular oedema. 21,22 Some studies suggest that vitreo-macular traction may play a role in increased retinal vascular permeability. 23,24 So, pars plana vitrectomy has been advocated for the treatment of macular oedema with or without a taut, attached posterior hyaloid.…”

Reversal of Abnormalities in Ocular Fluorophotometry in Insulin-dependent Diabetes After Five to Nine Months of Improved Metabolic Control

“…Recently, we have found that fluorescein injected into the vitreous is removed more slowly in diabetic and iodate-treated rats than in controls. 31 The improvement in anterior chamber fluorophotometry in patients with proliferative retinopathy seen in our study could represent improvement in anterior segment pigment epithelial function.…”

Surgical Management of Diabetic Macular Edema

“…Abnormal permeability of the inner blood-retinal barrier has been seen on fluorescein angiography and breakdown of the outer blood-retinal barrier has been implicated in animal models. 42,43 Condensation and contraction of the premacular hyaloidal membrane is thought to cause tangential vitreomacular traction (VMT) (rather than anteroposterior traction) in these patients without PVD and increase the permeability of the retinal vasculature. 7 In addition, imaging studies using OCT suggest that these tangential tractional forces can lead to a subclinical macular detachment.…”

Intravitreal triamcinolone as a primary therapy in diabetic macular oedema

“…20 In addition, both clinical observations and studies involving diabetic animal models have implicated breakdown of the outer blood-retinal barrier in the development of diabetic macular oedema. 21,22 Some studies suggest that vitreo-macular traction may play a role in increased retinal vascular permeability. 23,24 So, pars plana vitrectomy has been advocated for the treatment of macular oedema with or without a taut, attached posterior hyaloid.…”

Reversal of Abnormalities in Ocular Fluorophotometry in Insulin-dependent Diabetes After Five to Nine Months of Improved Metabolic Control

“…Recently, we have found that fluorescein injected into the vitreous is removed more slowly in diabetic and iodate-treated rats than in controls. 31 The improvement in anterior chamber fluorophotometry in patients with proliferative retinopathy seen in our study could represent improvement in anterior segment pigment epithelial function.…”

Surgical Management of Diabetic Macular Edema

“…Abnormal permeability of the inner blood-retinal barrier has been seen on fluorescein angiography and breakdown of the outer blood-retinal barrier has been implicated in animal models. 42,43 Condensation and contraction of the premacular hyaloidal membrane is thought to cause tangential vitreomacular traction (VMT) (rather than anteroposterior traction) in these patients without PVD and increase the permeability of the retinal vasculature. 7 In addition, imaging studies using OCT suggest that these tangential tractional forces can lead to a subclinical macular detachment.…”

Intravitreal triamcinolone as a primary therapy in diabetic macular oedema

“…20 In addition, both clinical observations and studies involving diabetic animal models have implicated breakdown of the outer blood-retinal barrier in the development of diabetic macular oedema. 21,22 Some studies suggest that vitreo-macular traction may play a role in increased retinal vascular permeability. 23,24 So, pars plana vitrectomy has been advocated for the treatment of macular oedema with or without a taut, attached posterior hyaloid.…”

Reversal of Abnormalities in Ocular Fluorophotometry in Insulin-dependent Diabetes After Five to Nine Months of Improved Metabolic Control

“…Recently, we have found that fluorescein injected into the vitreous is removed more slowly in diabetic and iodate-treated rats than in controls. 31 The improvement in anterior chamber fluorophotometry in patients with proliferative retinopathy seen in our study could represent improvement in anterior segment pigment epithelial function.…”

Surgical Management of Diabetic Macular Edema

“…Abnormal permeability of the inner blood-retinal barrier has been seen on fluorescein angiography and breakdown of the outer blood-retinal barrier has been implicated in animal models. 42,43 Condensation and contraction of the premacular hyaloidal membrane is thought to cause tangential vitreomacular traction (VMT) (rather than anteroposterior traction) in these patients without PVD and increase the permeability of the retinal vasculature. 7 In addition, imaging studies using OCT suggest that these tangential tractional forces can lead to a subclinical macular detachment.…”