Fluorine-18 Fluorodeoxyglucose with Positron Emission Tomography Revealed Bone Marrow Involvement in Sarcoidosis Patients with Anaemia

Prost, Nicolas de; Kerrou, Khaldoun; Sibony, Mathilde; Talbot, Jean-Noël; Wislez, Marie; Cadranel, Jacques

doi:10.1159/000204901

Cited by 18 publications

(5 citation statements)

References 27 publications

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“…As PET-CT is not routinely used for the diagnosis of sarcoidosis, there is no correct data about BM involvement rates yet. Yanardag and de Prost reported that, BM involvement must be suspected in case of anemia in a sarcoidosis patient [20,21]. In our study, BM involvement determined by PET-CT was significantly different between the two groups favoring the patients with lymphoma (p < 0.001).…”

Section: Discussioncontrasting

confidence: 38%

The differential diagnostic role of pet-CT in sarcoidosis and lymphoma

Kargi¹,

Süslü²,

Unsal³

et al. 2018

Curr Thorac Surg

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Section: Discussioncontrasting

confidence: 38%

The differential diagnostic role of pet-CT in sarcoidosis and lymphoma

Kargi¹,

Süslü²,

Unsal³

et al. 2018

Curr Thorac Surg

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“…This suggests that age-related changes in females, such as the hormonal dysregulation associated with menopause, may contribute to sarcoidosis. Although significant heterogeneity in disease presentation and disease severity occurs among different ethnic and racial groups [13,14,15,16], both of these pulmonary granulomatous diseases, sarcoidosis and nontuberculous mycobacterial disease, are likely to be characterized by a preponderance in postmenopausal females. Therefore, it is likely that fluctuations of sex hormones may be associated with enhanced granuloma formation in the lung.…”

Section: Introductionmentioning

confidence: 99%

Sex Hormones Alter Th1 Responses and Enhance Granuloma Formation in the Lung

Tajima

Miura²,

Ishiwata³

et al. 2011

Respiration

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Background: The lung is one of the sites of granulomatous responses, which are characterized by the recruitment and organization of activated macrophages and lymphocytes. There have been several reports that have shown that some pulmonary granulomatous diseases, such as sarcoidosis and nontuberculous mycobacterial disease, are likely to be characterized by a preponderance in postmenopausal females. Although sex hormones have been shown to play an important role in the regulation of the immune system, the influence of sex hormones on pulmonary granuloma formation is still unclear. Objectives: The purpose of this study was to assess whether sex hormones are involved in granulomatous inflammation and to evaluate how sex hormones modulate this response in the lung. Methods: Ovariectomized rats were used as an experimental postmenopausal model in which chronic pulmonary granulomatous inflammation was induced by intravenous injection of complete Freund’s adjuvant. Results: Histological analysis of lung tissues demonstrated enhancement of granuloma formation in the ovariectomized group. Such enhanced granuloma formation was significantly associated with generalized Th1-biased cytokine production in the bronchoalveolar lavage fluid. Conclusion: These results indicate that sex hormones play an important role in pulmonary granuloma formation by altering the Th1 responses.

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“…Bronchiectasis is uncommon form of sarcoidosis [21]. Anaemia is uncommon but if present, it is usually anaemia of chronic disease or autoimmune haemolyticanaemia can occur [22]. There can be leukopenia, eosinophilia.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Kumar¹

2018

Int J Case Rep Images

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Subcutaneous sarcoidosis is a multisystem granulomatous disease with cutaneous lesions present in about one fourth of patients. Diagnosis may require a high index of suspicion. A patient was referred to the respiratory clinic for evaluation of a firm, nontender, subcutaneous, mobile mass on the left forearm with bilateral hilar lymphadenopathy on the CT chest. There is a strong association between subcutaneous sarcoidosis and bilateral hilar lymphadenopathy (72.7%). Clinical and histopathological reports have confirmed subcutaneous sarcoidosis, also radiological examination with the hilar lymph node involvement. About 15% of patients have in order of frequency uveitis, parotitis, arthritis, mucositis, dactylitis, neurological and renal involvement, hepatosplenomegaly. This is a rare form of the nodular cutaneous sarcoidosis.

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Fluorine-18 Fluorodeoxyglucose with Positron Emission Tomography Revealed Bone Marrow Involvement in Sarcoidosis Patients with Anaemia

Abstract: sion: Whole-body 18 F-FDG PET imaging should be considered in sarcoidosis patients with symptomatic anaemia. It can noninvasively suggest bone marrow involvement, indicate sarcoidosis treatment and monitor its efficiency.

Cited by 18 publications

References 27 publications

The differential diagnostic role of pet-CT in sarcoidosis and lymphoma

The differential diagnostic role of pet-CT in sarcoidosis and lymphoma

Sex Hormones Alter Th1 Responses and Enhance Granuloma Formation in the Lung

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