Fluorescent sensing with Fresnel microlenses for optofluidic systems

Siudzińska, Anna; Miszczuk, A.; Marczak, Jacek; Komorowska, Katarzyna

doi:10.1117/1.oe.56.5.057106

Cited by 5 publications

(2 citation statements)

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“…TEs generally have a relatively high refractive index, with NOAs ranging from 1.52 to 1.56, , Ostemer 322 at 1.58, and PETMP/TATATO around 1.56 for all stochiometric ratios . For this reason, thiol–ene–epoxy and NOA-89 have been successfully used to prepare microoptical elements.…”

Section: Properties Of Thiol–ene Polymersmentioning

confidence: 99%

Thiol–Ene Based Polymers as Versatile Materials for Microfluidic Devices for Life Sciences Applications

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Geczy

Häfeli

et al. 2020

ACS Appl. Mater. Interfaces

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While there is a steady growth in the number of microfluidics applications, the search for an optimal material that delivers the diverse characteristics needed for the numerous tasks is still nowhere close to being settled. Often overlooked and still underrepresented, the thiol−ene family of polymer materials has an enormous potential for applications in organs-on-a-chip, droplet productions, microanalytics, and point of care testing. In this review, the main characteristics of the thiol−ene materials are given, and advantages and drawbacks with respect to their potential in microfluidic chip fabrication are critically assessed. Select applications, which exploit the versatility of the thiol−ene polymers, are presented and discussed. It is concluded that, in particular, the rapid prototyping possibility combined with the material's resulting mechanical strength, solvent resistance, and biocompatibility, as well as the inherently easy surface functionalization, are strong factors to make thiol−ene polymers strong contenders for promising future materials for many biological, clinical, and technical labon-a-chip applications.

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Section: Properties Of Thiol–ene Polymersmentioning

confidence: 99%

Thiol–Ene Based Polymers as Versatile Materials for Microfluidic Devices for Life Sciences Applications

Sticker

Geczy

Häfeli

et al. 2020

ACS Appl. Mater. Interfaces

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“…Fresnel lenses are flat, low thickness structures with concentric rings designed to focus the light (40% efficiency) in optical microfluidic devices (see Fig. 8b) Their fabrication within a microfluidic channel is based on the nanoimprint process (Siudzinska et al 2017). Efficient beaming of the emitted radiation is very important since it can drastically affect the performance of the assay.…”

Section: Optics Layer-integrated Designsmentioning

confidence: 99%

Miniaturization of fluorescence sensing in optofluidic devices

Măriuța

Colin

Barrot-Lattes

et al. 2020

Microfluid Nanofluid

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Successful development of a micro-total-analysis system (µTAS, lab-on-a-chip) is strictly related to the degree of miniaturization, integration, autonomy, sensitivity, selectivity, and repeatability of its detector. Fluorescence sensing is an optical detection method used for a large variety of biological and chemical assays, and its full integration within lab-on-a-chip devices remains a challenge. Important achievements were reported during the last few years, including improvements of previously reported methodologies, as well as new integration strategies. However, a universal paradigm remains elusive. This review considers achievements in the field of fluorescence sensing miniaturization, starting from off-chip approaches, representing miniaturized versions of their lab counter-parts, continuing gradually with strategies that aim to fully integrate fluorescence detection on-chip, and reporting the results around integration strategies based on optical-fiber-based designs, optical layer integrated designs, CMOS-based fluorescence sensing, and organic electronics. Further successful development in this field would enable the implementation of sensing networks in specific environments that, when coupled to Internet-of-Things (IoT) and artificial intelligence (AI), could provide real-time data collection and, therefore, revolutionize fields like health, environmental, and industrial sensing.

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Unmasking the Resolution–Throughput Tradespace of Focused‐Ion‐Beam Machining

Madison

Villarrubia

Liao

et al. 2022

Adv Funct Materials

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Focused‐ion‐beam machining is a powerful process to fabricate complex nanostructures, often through a sacrificial mask that enables milling beyond the resolution limit of the ion beam. However, current understanding of this super‐resolution effect is empirical in the spatial domain and nonexistent in the temporal domain. This article reports the primary study of this fundamental tradespace of resolution and throughput. Chromia functions well as a masking material due to its smooth, uniform, and amorphous structure. An efficient method of in‐line metrology enables characterization of ion‐beam focus by scanning electron microscopy. Fabrication and characterization of complex test structures through chromia and into silica probe the response of the bilayer to a focused beam of gallium cations, demonstrating super‐resolution factors of up to 6 ± 2 and improvements to volume throughput of at least factors of 42 ± 2, with uncertainties denoting 95% coverage intervals. Tractable theory models the essential aspects of the super‐resolution effect for various nanostructures. Application of the new tradespace increases the volume throughput of machining Fresnel lenses by a factor of 75, enabling the introduction of projection standards for optical microscopy. These results enable paradigm shifts of sacrificial masking from empirical to engineering design and from prototyping to manufacturing.

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Fluorescent sensing with Fresnel microlenses for optofluidic systems

Cited by 5 publications

References 0 publications

Thiol–Ene Based Polymers as Versatile Materials for Microfluidic Devices for Life Sciences Applications

Thiol–Ene Based Polymers as Versatile Materials for Microfluidic Devices for Life Sciences Applications

Miniaturization of fluorescence sensing in optofluidic devices

Unmasking the Resolution–Throughput Tradespace of Focused‐Ion‐Beam Machining

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