Fluorescein angiography and patchy skin discoloration: a case report

Kurli, Madhavi; Hollingworth, K; Kumar, Vikrant; Sandramouli, Soupramanien

doi:10.1038/sj.eye.6700361

Cited by 11 publications

(9 citation statements)

References 6 publications

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“…[5][6][7][8][9][10] However, complications after angiography have been reported, including mild nausea, vomiting, skin discoloration and severe anaphylactic shock. 19,20 With non-invasive OCT, CME following uveitis or post-cataract surgery can be detected. The quality and sensitivity of OCT images are at least as good as angiography; however, OCT has fewer complications.…”

Section: Sixmentioning

confidence: 99%

Incidence and risk factors for cystoid macular edema following scleral buckling

Lai

Yeh

2016

Eye

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PurposeTo investigate the incidence of cystoid macular edema (CME) after scleral buckling (SB) and verify the possible risk factors of CME.MethodsA retrospective, non-comparative, interventional case series study was conducted. Clinical charts of 130 consecutive patients who were underwent successful SB for primary retinal detachment (RD) from 2009 to 2013 were reviewed. Optical coherence tomography (OCT) was applied to detect CME. Data pertaining to patient demographics, pre- and postoperative visual acuity, surgical procedures, and postoperative OCT findings were recorded. Factors associated with CME were also analyzed.ResultsThe incidence of CME was 9/130 (6.9%). Risk factors for developing CME were older age (non-CME vs CME: 44.8±14.8 vs 57.3±5.3 years, P<0.05), more extensive RD (RD extent by clock hours; non-CME vs CME: 4.61±1.57 vs 5.78±1.39, P<0.05), macular detachment (non-CME vs CME: 51.2 vs 88.9%, P<0.05), and external drainage (non-CME vs CME: 38.8% vs 77.8%, P<0.05). There was no significant difference between patient with and without CME regarding the use of gas tamponade and the lens status. In patients with more extensive RD (macular detachment plus RD of more than 3 clock hours before surgery), 8 of 68 patients had CME after SB and only older age and external drainage factors were associated with CME.ConclusionsThe risk factors associated with CME after SB were older age, more extended RD, macular detachment, and external drainage. External drainage should be used with caution in older patients with more extensive RD.

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Section: Sixmentioning

confidence: 99%

Incidence and risk factors for cystoid macular edema following scleral buckling

Lai

Yeh

2016

Eye

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“…43,44 Patients also experience dizziness, headache, diarrhea, convulsions with bradycardia, circulatory problems, irritation at the injection site, vasovagal episodes (fainting), pruritus (itchy), urticaria (in 0.5% of patients with reactions), myocardial infarction, breathlessness, extravasation, thrombophlebitis (infl ammation of a clot in the superfi cial venous system), local tissue necrosis, laryngeal and facial edema, bronchospasm, and anaphylaxis and allergic reactions (in 0.5-1% of total patients). [43][44][45][46][47][48] The primary route of excretion is the kidney. 38 Cardiac arrest and death are very rare; the mortality rate is 0.0005%.…”

Section: Fluoresceinmentioning

confidence: 99%

Toxicity of Organic Fluorophores Used in Molecular Imaging: Literature Review

et al. 2009

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Fluorophores are potentially useful for in vivo cancer diagnosis. Using relatively inexpensive and portable equipment, optical imaging with fluorophores permits real-time detection of cancer. However, fluorophores can be toxic and must be investigated before they can be administered safely to patients. A review of published literature on the toxicity of 19 widely used fluorophores was conducted by searching 26 comprehensive biomedical and chemical literature databases and analyzing the retrieved material. These fluorophores included Alexa Fluor 488 and 514, BODIPY FL, BODIPY R6G, Cy 5.5, Cy 7, cypate, fluorescein, indocyanine green, Oregon green, 8-phenyl BODIPY, rhodamine 110, rhodamine 6G, rhodamine X, rhodol, TAMRA, Texas red, and Tokyo green. Information regarding cytotoxicity, tissue toxicity, in vivo toxicity, and mutagenicity was included. Considerable toxicity-related information was available for the Food and Drug Administration (FDA)-approved compounds indocyanine green and fluorescein, but published information on many of the non-FDA-approved fluorophores was limited. The information located was encouraging because the amounts of fluorophore used in molecular imaging probes are typically much lower than the toxic doses described in the literature. Ultimately, the most effective and appropriate probes for use in patients will be determined by their fluorescent characteristics and the safety of the conjugates.

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“…Apesar de ser considerada segura, inúmeras complicações relacionadas à injeção de fluoresceína intravenosa já foram relatadas na literatura (2)(3)(4)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23) . Com o intuito de evitá-las vários estudos foram realizados comparando a ocorrência de reações adversas e alterações laboratoriais entre diferentes concentrações de fluoresceína sódica, porém na maioria dos trabalhos a dosagem injetada foi praticamente a mesma, de 500 mg (4,9,13,19,22) .…”

Section: Discussionunclassified