2018
DOI: 10.1159/000485153
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Abstract: Extracellular fluid overload (FO), which is assessed using bioimpedance technologies, is an important predictor of outcome in dialysis patients and in patients with early stages of chronic kidney disease. While traditional cardiovascular abnormalities are assumed to mediate this risk, recently also, the importance of noncardiovascular factors, such as systemic inflammation and malnutrition has been shown. While both FO and inflammation are independent risk factors for mortality, recent studies have shown that … Show more

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Cited by 51 publications
(56 citation statements)
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“…Compared to the l‐BNP group, the h‐BNP group had less muscle strength, lower body weight, lower lean tissue index and lower levels of hemoglobin and albumin, but higher CRP levels. These findings indicate malnutrition and inflammation, which have been associated with overhydration . However, although the h‐BNP group had higher CRP levels, we were not able to confirm the association between overhydration and IL‐6 and TNF‐alpha or any other inflammatory markers, which has been found in studies with larger samples …”
Section: Discussioncontrasting
confidence: 84%
See 1 more Smart Citation
“…Compared to the l‐BNP group, the h‐BNP group had less muscle strength, lower body weight, lower lean tissue index and lower levels of hemoglobin and albumin, but higher CRP levels. These findings indicate malnutrition and inflammation, which have been associated with overhydration . However, although the h‐BNP group had higher CRP levels, we were not able to confirm the association between overhydration and IL‐6 and TNF‐alpha or any other inflammatory markers, which has been found in studies with larger samples …”
Section: Discussioncontrasting
confidence: 84%
“…These findings indicate malnutrition and inflammation, which have been associated with overhydration . However, although the h‐BNP group had higher CRP levels, we were not able to confirm the association between overhydration and IL‐6 and TNF‐alpha or any other inflammatory markers, which has been found in studies with larger samples …”
Section: Discussionmentioning
confidence: 96%
“…The relation between FO and inflammation is likely complex and has been discussed in detail in a recent review paper [34]. Although it appears likely that an increased capillary permeability would play a major role in this phenomenon, the single study addressing this subject observed that capillary leakage, assessed by the Iodine-125 albumin method, was more strongly related to markers of platelet activation as compared to inflammatory markers in a cohort of PD patients [35].…”
Section: Non-cardiovascular Factors On Abnormalities In Fluid Statusmentioning
confidence: 99%
“…The mechanisms of the relation between FO and malnutrition remain to be elucidated and may range from a lack of adjustment of dry weight in cases where a decline in fat or lean tissue mass goes undetected, the combined presence of inflammation and hypoalbuminemia leading to an alteration in fluid distribution or the presence of underlying illness which makes the patient more prone to hemodynamic instability making the achievement of dry weight more difficult [34]. It has also been suggested that malnutrition without renal failure itself leads to an increase in the ECV: weight ratio [39], but this may be also due to a change in the denominator.…”
Section: Non-cardiovascular Factors On Abnormalities In Fluid Statusmentioning
confidence: 99%
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