2010
DOI: 10.1016/j.devcel.2010.05.010
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Abstract: Cell competition promotes the elimination of weaker cells from a growing population. Here we investigate how cells of Drosophila wing imaginal discs distinguish "winners" from "losers" during cell competition. Using genomic and functional assays, we have identified several factors implicated in the process, including Flower (Fwe), a cell membrane protein conserved in multicellular animals. Our results suggest that Fwe is a component of the cell competition response that is required and sufficient to label cell… Show more

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Cited by 188 publications
(235 citation statements)
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References 42 publications
(62 reference statements)
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“…Therefore deregulated SWH signaling could contribute to the increased proliferative potential of Rac1 1 Ras ACT or scrib 2 1 Ras ACT tumors independently of JNK. Other factors, such as the relative level of the Myc cell growth protein, which has been shown to affect the survival of lgl 2 clones in the wing disc (Froldi et al 2010), or the recently discovered membrane protein isoform, FlowerLose, which is associated with dying cells in cell competition (Rhiner et al 2010), may also be involved in the overgrowth of Rac1 1 Ras ACT or scrib 2 1 Ras ACT tumors.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore deregulated SWH signaling could contribute to the increased proliferative potential of Rac1 1 Ras ACT or scrib 2 1 Ras ACT tumors independently of JNK. Other factors, such as the relative level of the Myc cell growth protein, which has been shown to affect the survival of lgl 2 clones in the wing disc (Froldi et al 2010), or the recently discovered membrane protein isoform, FlowerLose, which is associated with dying cells in cell competition (Rhiner et al 2010), may also be involved in the overgrowth of Rac1 1 Ras ACT or scrib 2 1 Ras ACT tumors.…”
Section: Discussionmentioning
confidence: 99%
“…Unbiased screens have been performed to identify specific cellular components that detect growth differentials and lead to the death of loser cells. A screen to identify genes that are upregulated in loser cells brought a dramatic advance as it led to the identification of Flower as a multipass transmembrane protein required for cell competition in myc and Minute mosaics 22 . The role of Flower has been extensively reviewed and will therefore only be briefly described here.…”
Section: Seeking Mediators Of Cell Competitionmentioning
confidence: 99%
“…Another, non-mutually exclusive possibility is that cell competition may be more readily detected in epithelia because of their planar organization. The discovery of cell competition and most of the sub sequent mechanistic insight came from studies of D. melano gaster appendages 13,14,[16][17][18][19][20][21][22][23] in which it is relatively easy to generate genetic mosaics 24 that confront cells with different features, including growth rates. This can be achieved, for example, by genetically reducing or boosting translational activity in a clone of cells within the tissue 13,14,25,26 .…”
mentioning
confidence: 99%
“…Recent Drosophila studies have shown that normal and transformed cells can recognize the difference(s) between them during cell competition. For example, a membrane protein Flower has been shown to play a role in intercellular recognition between normal and dMyc-overexpressing cells [15]. It remains to be studied whether a comparable molecular mechanism is also involved in cell competition in mammals.…”
Section: Translocation From the Epithelium Or Perturbation Of Intercementioning
confidence: 99%