Flower cells in patients with infective dermatitis associated with HTLV-1

Oliveira, Maria de Fátima; Vieira, Maria das Graças; Primo, Janeusa; Siqueira, Isadora Cristina de; Carvalho, Edgar M.; Farré, Lourdes; Fatal, Priscila Lima; Bittencourt, Achiléa Lisboa

doi:10.1016/j.jcv.2010.05.005

Cited by 16 publications

(11 citation statements)

References 17 publications

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“…IDH patients typically have a high HTLV-1 proviral load, comparable to HAM/TSP patients [26]. IDH is suspected to increase the risk of HAM/TSP or ATLL development [26], [27], [28], [29], but the evidence is not conclusive.…”

Section: Introductionmentioning

confidence: 99%

Strongyloidiasis and Infective Dermatitis Alter Human T Lymphotropic Virus-1 Clonality in vivo

et al. 2013

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Human T-lymphotropic Virus-1 (HTLV-1) is a retrovirus that persists lifelong by driving clonal proliferation of infected T-cells. HTLV-1 causes a neuroinflammatory disease and adult T-cell leukemia/lymphoma. Strongyloidiasis, a gastrointestinal infection by the helminth Strongyloides stercoralis, and Infective Dermatitis associated with HTLV-1 (IDH), appear to be risk factors for the development of HTLV-1 related diseases. We used high-throughput sequencing to map and quantify the insertion sites of the provirus in order to monitor the clonality of the HTLV-1-infected T-cell population (i.e. the number of distinct clones and abundance of each clone). A newly developed biodiversity estimator called “DivE” was used to estimate the total number of clones in the blood. We found that the major determinant of proviral load in all subjects without leukemia/lymphoma was the total number of HTLV-1-infected clones. Nevertheless, the significantly higher proviral load in patients with strongyloidiasis or IDH was due to an increase in the mean clone abundance, not to an increase in the number of infected clones. These patients appear to be less capable of restricting clone abundance than those with HTLV-1 alone. In patients co-infected with Strongyloides there was an increased degree of oligoclonal expansion and a higher rate of turnover (i.e. appearance and disappearance) of HTLV-1-infected clones. In Strongyloides co-infected patients and those with IDH, proliferation of the most abundant HTLV-1+ T-cell clones is independent of the genomic environment of the provirus, in sharp contrast to patients with HTLV-1 infection alone. This implies that new selection forces are driving oligoclonal proliferation in Strongyloides co-infection and IDH. We conclude that strongyloidiasis and IDH increase the risk of development of HTLV-1-associated diseases by increasing the rate of infection of new clones and the abundance of existing HTLV-1+ clones.

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Section: Introductionmentioning

confidence: 99%

Strongyloidiasis and Infective Dermatitis Alter Human T Lymphotropic Virus-1 Clonality in vivo

et al. 2013

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“…Human T-cell leukemia virus type I (HTLV-I) was the first retrovirus identified in humans, isolated from a patient with cutaneous lymphoma (Poiesz et al 1980 ). HTLV-I is the cause of not only adult T-cell leukemia/lymphoma (ATL) (Uchiyama et al 1977 ; Hinuma et al 1981 ) but also HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP) (Osame et al 1986 ), HTLV-I-associated uveitis (HU) (Ohba et al 1989 ; Mochizuki et al 1992 ) and infective dermatitis (McGill et al 2012 ; de Oliveira et al 2010 ).…”

Section: Introductionmentioning

confidence: 99%

A case of post-transplant adult T-cell leukemia/lymphoma presenting myelopathy similar to but distinct from human T-cell leukemia virus type I (HTLV- I)-associated myelopathy

et al. 2014

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IntroductionAdult T-cell leukemia/lymphoma (ATL) responds poorly to conventional chemotherapy, but allogeneic stem cell transplantation (allo-SCT) may improve disease prognosis. Herein, we report a female patient with human T-cell leukemia virus type I (HTLV-I)-associated myelopathy (HAM)-like myelopathy following allo-SCT for ATL.Case reportShe developed crural paresis 14 months after allo-SCT. Initially, she was diagnosed with central nervous system (CNS) relapse of ATL and treated with intrathecal injection and whole brain and spine irradiation. Her symptoms recurred 5 months later, when a cerebrospinal fluid (CSF) specimen showed increased CD4 + CXCR3 + CCR4+ cell numbers and levels of neopterin and CXCL10 (IP-10).DiscussionThese results suggest the possible involvement of a certain immunological mechanism such as HAM in her symptoms, irrespective of the lack of anti-HTLV-I antibody in her CSF. Because a definitive diagnosis of CNS manifestation of ATL is sometimes difficult, multi-modal laboratory data are required for differential diagnosis.

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“…In this study, four cases of ID were found, such as Okajima et al ., who found three cases of ID in their work, however, other studies have not reported patients with this diagnosis . It should be considered that patients from this and the other cited studies were predominantly adults and although cases of ID have been reported in adults, the disease is rare and is considered a form of childhood dermatitis …”

Section: Discussionmentioning

confidence: 45%

“…However, cases of ID have been reported in adults as well. It is presented as an exudative eruption involving mainly seborrheic areas such as: scalp, forehead, eyelids, paranasal sinuses, external ear, periauricular region, neck, armpits, and inguinal region . Differential diagnosis should be made with atopic dermatitis and seborrheic dermatitis …”

Section: Introductionmentioning

confidence: 99%

Dermatological manifestations in patients with human T‐cell lymphotropic virus at a reference service in Amazon

et al. 2019

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Introduction Individuals infected with the human T‐cell lymphotropic virus type 1 (HTLV‐1) commonly present skin lesions, which may be a warning sign for the diagnosis of infection. This study describes the most prevalent skin manifestations in HTLV carriers attended at the clinic of Núcleo de Medicina Tropical (NMT) of the Universidade Federal do Pará (UFPA) in Belém, Pará, Brazil. Methods This is a study of a series of cases of patients infected with human T‐cell lymphotropic virus types 1 and 2 (HTLV‐1/2) treated at NMT UFPA between 1999 and 2016. A descriptive analysis of data was applied. Results Among 788 surveyed medical records in the service, 15.10% (n = 119) were referred to the dermatology clinic. From the series of cases that presented with skin lesions, 66.39% were female and 33.61% were male, and the average age of this group was 48 years. There was a predominance of patients with noninfectious inflammatory manifestations (64.2%), followed by infectious ones (24.6%), and 1.58% with lymphoproliferative diseases. As for the group of lesions, 45.26% of the erythematous‐squamous type were observed, followed by dyschromia (24.21%), and eczematous (14.74%). One patient with a diagnosis of adult T‐cell leukemia/lymphoma, another with parapsoriasis, and four with infective dermatitis are highlighted. Conclusion Skin disorders in the HLTV positive patient are important causes of referral to the dermatologist with etiological and skin lesions groups diversity. In the series of cases studied, lymphoproliferatives diseases and infective dermatitis associated with HTLV‐1 were presented as a challenge for the diagnosis and clinical management of these patients.

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Flower cells in patients with infective dermatitis associated with HTLV-1

Cited by 16 publications

References 17 publications

Strongyloidiasis and Infective Dermatitis Alter Human T Lymphotropic Virus-1 Clonality in vivo

Strongyloidiasis and Infective Dermatitis Alter Human T Lymphotropic Virus-1 Clonality in vivo

A case of post-transplant adult T-cell leukemia/lymphoma presenting myelopathy similar to but distinct from human T-cell leukemia virus type I (HTLV- I)-associated myelopathy

Dermatological manifestations in patients with human T‐cell lymphotropic virus at a reference service in Amazon

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