Flow chemistry vs. flow analysis

Trojanowicz, Marek

doi:10.1016/j.talanta.2015.07.043

Cited by 23 publications

(13 citation statements)

References 124 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It seems, however, that, in terms of the scale of reported processes, the choice of the employed physico-chemical unit operations, and the adoption of similar instrumental constructions, the closest similarity can be found between flow analysis and laboratory flow synthesis. Although this was already pointed out in an earlier review [94], as well as in the Website review [95], there is still almost a complete lack of interrelation between scientists contributing to each field, i.e., organic chemists working on flow synthesis and analysts working on flow analysis, which inclined us to present the development trends in these two areas of flow chemistry once again.…”

Section: Similarities In Development Trends In Flow Analysis and Flowmentioning

confidence: 99%

Flow Chemistry in Contemporary Chemical Sciences: A Real Variety of Its Applications

Trojanowicz

2020

Molecules

Self Cite

View full text Add to dashboard Cite

Flow chemistry is an area of contemporary chemistry exploiting the hydrodynamic conditions of flowing liquids to provide particular environments for chemical reactions. These particular conditions of enhanced and strictly regulated transport of reagents, improved interface contacts, intensification of heat transfer, and safe operation with hazardous chemicals can be utilized in chemical synthesis, both for mechanization and automation of analytical procedures, and for the investigation of the kinetics of ultrafast reactions. Such methods are developed for more than half a century. In the field of chemical synthesis, they are used mostly in pharmaceutical chemistry for efficient syntheses of small amounts of active substances. In analytical chemistry, flow measuring systems are designed for environmental applications and industrial monitoring, as well as medical and pharmaceutical analysis, providing essential enhancement of the yield of analyses and precision of analytical determinations. The main concept of this review is to show the overlapping of development trends in the design of instrumentation and various ways of the utilization of specificity of chemical operations under flow conditions, especially for synthetic and analytical purposes, with a simultaneous presentation of the still rather limited correspondence between these two main areas of flow chemistry.

show abstract

Section: Similarities In Development Trends In Flow Analysis and Flowmentioning

confidence: 99%

Flow Chemistry in Contemporary Chemical Sciences: A Real Variety of Its Applications

Trojanowicz

2020

Molecules

Self Cite

View full text Add to dashboard Cite

show abstract

“…Voltammetry measurements can be performed in quiescent, under solution stirring or in flow that improves the mass transport to the working electrode and lowers the detection limit to reach the range important from the clinical point of view. Moreover, using flow or batch injection analysis speeds up the test time and improves the throughput of samples [25]. Since Ags and Abs are not intrinsically electroactive, a label is usually linked to the Ag or the Ab to produce the electrochemical signal [26].…”

Section: Platform Design For Ad Biosensorsmentioning

confidence: 99%

Electrochemical Biosensors as Potential Diagnostic Devices for Autoimmune Diseases

et al. 2019

View full text Add to dashboard Cite

An important class of biosensors is immunosensors, affinity biosensors that are based on the specific interaction between antibodies and antigens. They are classified in four classes based on the type of employed transducer: electrochemical, optical, microgravimetric, and thermometric and depending on the type of recognition elements, antibodies, aptamers, microRNAs and recently peptides are integrating parts. Those analytical devices are able to detect peptides, antibodies and proteins in various sample matrices, without many steps of sample pretreatment. Their high sensitivity, low cost and the easy integration in point of care devices assuring portability are attracting features that justify the increasing interest in their development. The use of nanomaterials, simultaneous multianalyte detection and integration on platforms to form point-of-care devices are promising tools that can be used in clinical analysis for early diagnosis and therapy monitoring in several pathologies. Taking into account the growing incidence of autoimmune disease and the importance of early diagnosis, electrochemical biosensors could represent a viable alternative to currently used diagnosis methods. Some relevant examples of electrochemical assays for autoimmune disease diagnosis developed in the last several years based on antigens, antibodies and peptides as receptors were gathered and will be discussed further.

show abstract

“…A similar comment could be done in relation to flow chemistry, which essentially exploits the same concepts involved in flow analysis, although the previous developments in the analytical field have been rarely mentioned. 52 A recent work entitled "Flow chemistry vs. flow analysis" 53 highlighted the similarities observed in the flow approaches designed either to analytical or synthetic aims as well as the synergistic developments which could be achieved by considering the advances in these fields in conjunct. The author also envisioned that the term "flow chemistry" will encompass the approaches for analytical and synthetic purposes in the future.…”

Section: Looking Forward: Research Perspectives On Flow Analysismentioning

confidence: 99%

Flow Analysis: Looking Back and Forward

Rocha¹

2018

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

Flow analysis changed significantly the way of performing chemical analysis by (i) mechanization of analytical procedures in a continuous flowing stream with minimal sample intercontamination; (ii) analytical measurements without attaining chemical equilibria, thus increasing the applicability of kinetic methods and allowing the exploitation of non-quantitative processes; (iii) exploitation of concentration gradients and (iv) use of unstable reagents or measurement of unstable products. Flow-based procedures are generally characterized by high sample throughput, improved precision, minimized waste generation, and often better selectivity. The performance of detection systems is usually improved because of the in-line sample conditioning and measurements under reproductive dynamic conditions and timing. However, after achieving several innovations, perspectives for further developments have been questioned mainly because of the recent decrease in the number of publications on flow analysis. The aim of this review is then to discuss the impact of flow-based methods on chemical analysis, emphasizing recent applications and developments, including miniaturization, bioanalysis, microextractions, green analytical chemistry and synergic hyphenation with other techniques and processes. The author's personal view about research perspectives in the field is also presented.

show abstract

Flow chemistry vs. flow analysis

Cited by 23 publications

References 124 publications

Flow Chemistry in Contemporary Chemical Sciences: A Real Variety of Its Applications

Flow Chemistry in Contemporary Chemical Sciences: A Real Variety of Its Applications

Electrochemical Biosensors as Potential Diagnostic Devices for Autoimmune Diseases

Flow Analysis: Looking Back and Forward

Contact Info

Product

Resources

About