Florid cutaneous papillomatosis with adenocarcinoma of stomach in a 35 year old male

Singhi, M. K.; Gupta, LK; Bansal, Mohit; Jain, V. K.; Kachhawa, Dilip

doi:10.4103/0378-6323.16238

Cited by 15 publications

(12 citation statements)

References 4 publications

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“…There have been reports suggesting coexistence of acanthosis nigricans and the sign of Leser-Trélat and florid cutaneous papillomatosis in patients with gastric adenocarcinoma [4,5] which is the commonly associated malignancy but in our case the associated primary is a squamous cell carcinoma of the esophagus which is unusual.…”

mentioning

confidence: 52%

A myriad of paraneoplastic dermatoses

Varghese

Sobhanakumari

Issac

et al. 2011

Indian J Dermatol Venereol Leprol

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Sir, Paraneoplastic dermatoses, describes those benign disorders in which there is a direct and often parallel course of the dermatosis with an underlying malignancy. Their presence serves as an important marker of a potentially-associated neoplastic process. We are reporting a case with multiple cutaneous paraneoplastic manifestations seen in association with an upper gastrointestinal (GI) malignancy.A 76-year-old man presented with generalized, pruritic, hyperpigmented raised lesions for 4 years and hyperpigmentation over the sides of neck, axilla, and thighs for 4 years.On examination, patient appeared emaciated; pallor was present and there was no significant lymphadenopathy or systemic findings. He had hyperpigmented velvety plaques over neck, axilla, groin, areola, and lips suggestive of acanthosis nigricans (AN); numerous verrucous papules and plaques with a stuck-on appearance over trunk, face, scalp, and proximal extremities suggestive of seborrheic keratosis [ Figure 1]; palms showed hyperkeratosis and altered dermatoglyphics suggestive of tripe palms and verrucous papules typifying verruca vulgaris seen over extensor surfaces of extremities [ Figure 2]. Net LetterHow to cite this article: Varghese SA, Sobhanakumari K, Issac CM, Seena P. A myriad of paraneoplastic dermatoses. Indian J Dermatol Venereol Leprol 2011;77:626.

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confidence: 52%

A myriad of paraneoplastic dermatoses

Varghese

Sobhanakumari

Issac

et al. 2011

Indian J Dermatol Venereol Leprol

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“…AN with sudden onset, rapid progression, profound hyperkeratosis, and hyperpigmentation with coexisting pruritus and unexplained weight loss in older adults is usually associated with malignancy. 13 In our case, a malignancy was suspected due to the rapid progression of skin lesion, involvement of oral mucosal membrane, and history of heavy smoking. Malignant AN has been mostly reported to be associated with tumors of gastrointestinal tract (90%), especially with carcinoma of stomach; 5 liver, gall bladder, and bile duct cancers; 14 , 15 and carcinoma of colon.…”

Section: Discussionmentioning

confidence: 85%

A case of acanthosis nigricans as a paraneoplastic syndrome with squamous cell lung cancer

Karakaş

Esin

Laçin

et al. 2016

OTT

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A 55-year-old man presented with oral mucosal ulcers, blackening of both hands, and hyperpigmentation on axillary, anal, and inguinal regions for the last 3 months, which were all progressive. The patient was referred to the oncology department with the diagnosis of acanthosis nigricans for investigation of an underlying malignancy. He was a smoker. A computed tomography scan of thorax revealed enlarged mediastinal lymphadenopathies and a lesion on the left upper lobe. Fine-needle aspiration biopsy of the mediastinal lesion was consistent with squamous cell carcinoma, and biopsies of the skin and oral mucosal lesion also further confirmed the diagnosis of acanthosis nigricans. After docetaxel and cisplatin chemotherapy, a significant improvement in his skin and mucosal lesions was observed with almost complete resolution of the pulmonary lesion and the mediastinal lymph nodes.

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“…The paraneoplastic dermatoses that have been reportedly associated with gastric adenocarcinoma are acanthosis nigricans, tripe palms, and florid cutaneous papillomatoses. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

Darier′s disease in gastric malignancy: An unusual paraneoplastic phenomenon

et al. 2015

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Darier's disease is an autosomal dominant genodermatosis resulting from ATP2A2 gene mutation. A 62-year-old male presented at our outpatient (OPD) with sudden-onset numerous dirty, warty papules over the head, neck, and back since 2 months. Histopathology of the skin lesions revealed acantholytic dyskeratosis suggestive of Darier's disease. He was referred to the gastroenterology department for some gastrointestinal (GI) symptoms where he was diagnosed with adenocarcinoma of the stomach and was subsequently operated. On his next visit to our department for follow-up, we found a marked diminution of the skin lesions in the absence of any specific treatment. In view of the above finding, we concluded that paraneoplastic dermatosis in the form of Darier's disease occurred in this patient. Paraneoplastic Darier's disease with gastric adenocarcinoma is not yet described in dermatology literature and is hence reported here.

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Florid cutaneous papillomatosis with adenocarcinoma of stomach in a 35 year old male

Cited by 15 publications

References 4 publications

A myriad of paraneoplastic dermatoses

A myriad of paraneoplastic dermatoses

A case of acanthosis nigricans as a paraneoplastic syndrome with squamous cell lung cancer

Darier′s disease in gastric malignancy: An unusual paraneoplastic phenomenon

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