Floating Microspheres - An Excellent Approach for Gastric Retention

Sudheer, Preeti; Kumar, H. N. Naveen; Thomas, Litha; Nethravathi, D. R.

doi:10.18579/jpcrkc/2015/14/4/89442

Cited by 3 publications

(4 citation statements)

References 6 publications

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“…Floating Microspheres: 33,34,35,36,37 There are various methods of preparation of floating microspheres.…”

Section: Methods Of Preparation Of Gastro-retentivementioning

confidence: 99%

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2020

IJPSR

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“…Floating Microspheres: 33,34,35,36,37 There are various methods of preparation of floating microspheres.…”

Section: Methods Of Preparation Of Gastro-retentivementioning

confidence: 99%

“…Factors to Be Considered for Development of GRDDS: 2,26,31,33 Density: Dosage forms having less density than gastric contents (1.004 g/L) have a tendency of floating drug delivery system.…”

Section: Disadvantages Of Grdds: 1 26 29mentioning

confidence: 99%

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2020

IJPSR

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“…well while maintaining warmth, and then the mixture is cooled to 25°C. Further cooling to 10°C solidifies the coating [44,45].…”

Section: Non-solvent Additionmentioning

confidence: 99%

Advances in the Preparation Techniques of Floating Microspheres with Exploration of AI Tool in Product Development

2023

PDRAJ

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This review paper focuses on recent developments in gastroretentive drug delivery systems for controlled release oral drug administration. Gastric emptying’s variability presents challenges to drug delivery systems, making gastroretentive drug delivery systems increasingly popular for retaining drugs in the stomach and ensuring gradual release. Traditional oral delivery systems often fail to overcome gastrointestinal obstacles, resulting in incomplete drug release, decreased efficacy. Thus, achieving prolonged gastric residence times is crucial, particularly for drugs with upper small intestine absorption windows. Gastro retentive drug delivery system provide for prolonged drug release in the upper digestive system, improving bioavailability for drugs with narrow therapeutic windows, extending dosing intervals, and enhancing patient compliance. The purpose of this review is to discuss recent advancements in the preparation techniques for floating drug delivery systems and highlights the incorporation of AI-Enabled design and optimization in drug release behavior. These technologies enhance precision and efficiency in gastroretentive drug delivery systems development, promising further improvements in drug delivery effectiveness and patient adherence.

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“…It is one of the most comprehensively used routes of drug administration because of its evident advantages of ease of administration enhanced patient fulfillment, and ease. (Sudheer et al, 2014).Numerous studies have been carried out to increase the dissolution rate of drugs by decreasing the size of particles, by creating nano and microparticles. Another method of expanding the dissolution rate is the adsorption of the drug onto a high-surface-area carrier (Sworth et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Enhancement of dissolution rate through design and techniques of liquisolid tablets formulation

Tiwari¹,

Yadav²,

Sharma³

2020

Adv Pharm J

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The solubility and dissolution properties of every drug are vital determinants of its oral bioavailability. A large portion of the recently evolved drugs are lipophilic and poorly water-soluble. Upgrading the dissolution and bioavailability of these medications is a main challenge for the pharmaceutical industry. During the development of another medication, it is imperative to guarantee its fundamental bioavailability. Here comes the requirement for a Liquisolid procedure which is a novel and promising way to deal with beat the outcomes. The strategy depends on the dissolving the insoluble medication in the nonvolatile solvent and admixture of drug solution with a reasonable carrier and coating materials to change over into acceptably flowing and compressible powders. The Liquisolid technique can also be used for the enhancement and retardation of drug release. The target of this article is to introduce a review of the Liquisolid strategy, the formulation, and designing of the liquisolid system and review the progress of its applications in pharmaceutics. Low cost, easy processing and great potentials in industrial production are the main advantages of this approach.

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Floating Microspheres - An Excellent Approach for Gastric Retention

Cited by 3 publications

References 6 publications

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Advances in the Preparation Techniques of Floating Microspheres with Exploration of AI Tool in Product Development

Enhancement of dissolution rate through design and techniques of liquisolid tablets formulation

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