Floating capsules containing alginate-based beads of salbutamol sulfate: In vitro–in vivo evaluations

Malakar, Jadupati; Datta, Prabir Kumar; Purakayastha, Saikat Das; Dey, Sanjay; Nayak, Amit Kumar

doi:10.1016/j.ijbiomac.2013.11.014

Cited by 55 publications

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References 30 publications

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“…A c c e p t e d M a n u s c r i p t 5 high solubility and swellability of the pectinate beads in aqueous fluid typically resulted in 79 poor encapsulation and premature release of the entrapped drug molecules (Nayak and Pal,80 2013; Nayak et al, 2014). Interestingly, previous studies have revealed that the blending of …”

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confidence: 99%

“…Quadratic models including interactive and polynomial terms were generated 155 to analyze each response. The equation can be expressed as (Nayak et al, 2014):…”

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confidence: 99%

“…An increase in polymer level exhibited 452 lower drug release rate. The matrices with higher polymer contents could bind more tightly to 453 water molecules to form a viscous gel structure, which might block the pores on the surface 454 of the beads and eventually sustain the drug release from these beads(Nayak et al, 2014).455 Moreover, a higher level of polymer produced beads of larger particle size, which in turn456 resulted in an increased drug diffusional path-length (Nayak et al, 2014). On the other hand, 457 an increase in LM-pectin concentration in polymer blend was accompanied by 458 a decrease in drug release rate.…”

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confidence: 99%

“…various interactions like hydrogen bonding, van der Waal's forces and ionic interactions533 and thus, IPN matrices imparted mucoadhesivity(Pliszczak et al, 2012;Nayak et al, 2014).534 It was noticed that the ex vivo wash-off of the formulations containing a higher proportion of 535 polymer was slower than those formulations with low polymer contents. The slow wash-off 536 observed for the beads with higher polymer contents could be caused by higher unionization functional groups (mainly carboxyl moieties) of the polymers in the acidic medium,538 resulting in decreased solubility with enhanced adhesive strength (Nayak et al, The % buoyancy (a) and % mucoadhesion (b) of the Zn-pectinate-SG IPN beads 541 containing ziprasidone HCl at 8 h in simulated gastric fluid (pH 1.2).…”

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Mucoadhesive-floating zinc-pectinate–sterculia gum interpenetrating polymer network beads encapsulating ziprasidone HCl

Bera¹,

Boddupalli²,

Nayak

2015

Carbohydrate Polymers

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101

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confidence: 99%

“…Quadratic models including interactive and polynomial terms were generated 155 to analyze each response. The equation can be expressed as (Nayak et al, 2014):…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Mucoadhesive-floating zinc-pectinate–sterculia gum interpenetrating polymer network beads encapsulating ziprasidone HCl

Bera¹,

Boddupalli²,

Nayak

2015

Carbohydrate Polymers

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101

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“…Now a day, a variety of drug delivery devices has been explored to retain in the gastrointestinal tract (GIT) [1][2][3]. In both academia and industry, a lot of efforts have been made towards the development of numerous types of gastro retentive deliveries for several drug candidates [4][5].…”

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Floating-Bioadhesive Matrix Tablets of Hydralazine HCL Made of Cashew Gum and HPMC K4m

Hasnain

Rishishwar

Ali

2017

Int J Pharm Pharm Sci

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Objective: The objective of this paper was to prepare and evaluate floating-bioadhesive cashew gum-hydroxypropyl methylcellulose (HPMC K4M) matrix tablets for the gastro-retentive release of hydralazine HCl. Methods:The cashew gum-HPMC K4M matrix tablets of hydralazine HCl were prepared by direct compression method with the incorporation of sodium bicarbonate and citric acid as effervescent agents. Drug contents, weight variations, hardness, friability, in vitro swelling, in vitro floatation, ex vivo mucoadhesion and in vitro drug release of these matrix tablets were evaluated.Results: Drug contents, weight variations, hardness and friability of these matrix tablets were within the compendia limits. These tablets were floated well in vitro over 12 h in simulated gastric fluid (SGF, pH 1.2) with minimum lag time. The ex vivo adhesion of these matrix tablets with goat intestinal mucosa exhibited good bioadhesion in a wash off test. All these cashew gum-HPMC K4M floating-bioadhesive matrix tablets of hydralazine HCl showed in vitro sustained releases of hydralazine HCl over 12 h in SGF, pH 1.2. The in vitro hydralazine HCl followed Korsmeyer-Peppas kinetic model and anomalous (non-Fickian) diffusion mechanism. The drug-polymer compatibility analysis by FTIR spectroscopy indicated the absence of any drug-polymer interaction within this cashew gum-HPMC K4M floating-bioadhesive matrix tablets of hydralazine HCl. Conclusion:The results clearly indicate a promising potential of the use of cashew gum as matrix forming a material with HPMC K4M to prepare matrix tablets for gastro retentive delivery of hydralazine HCl through the combined approach of floatation and bioadhesion to reduce the dosing rate with better patient compliances.

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Formulation characterization and in vitro evaluation of acacia gum–calcium alginate beads for oral drug delivery systems

Benfattoum

Haddadine

Bouslah

et al. 2017

Polymers for Advanced Techs

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In the present work, new matrix bead formulations based on linear and branched polysaccharides have been developed using an ionic gelation technique, and their potential use as oral drug carriers has been evaluated. Using calcium chloride as a cross-linking agent and sodium diclofenac (SD), as a model drug, acacia gum-calcium alginate matrix beads were formulated.The response surface methodology based on 3 2 factorial design was used as a statistical method to evaluate and optimize the effects of the biopolymers-blend ratio and the concentration of calcium chloride on the particle size (mm), density (g/cm 3 ), drug encapsulation efficiency (%), and the cumulative drug release after 8 hours (R 8h ,%). The optimized beads with the highest drug encapsulation efficiency were examined for a drug-excipients compatibility by powder X-ray diffraction, differential scanning calorimetry, thermo-gravimetric analysis, and Fourier transforminfrared spectroscopy analyses. The swelling and degradation of the matrix beads were found to be influenced by the pH of medium. Higher degrees of swelling were observed in intestinal pH than in stomach pH. Accordingly, the drug release study showed that the amount of SD released from the acacia gum-calcium alginate beads was higher in intestinal pH than in stomach pH. Therefore, the in vitro drug release from the SD-loaded beads appears to follow the controlledrelease (Hixson-Crowell) pattern involving a case-2 transport mechanism operated by swelling and relaxation of the polymeric blend matrix. KEYWORDS acacia gum-calcium alginate, beads, branched polysaccharide, linear polysaccharide, oral drug delivery 1 | INTRODUCTION Polysaccharides represent a class of natural chemical compounds characterized by repetitive structural units with a wide degree of dispersion. 1 A growing interest in these chemical compounds has resulted in the identification of a number of important biochemical and biomedical applications, not only because of their low cost, biocompatibility, biodegradability, high swelling capability, and stability in various pHs but also because of their potential use in controlled drug delivery systems. 1-4 Different forms of natural polysaccharides such as nanostructures, 5,6 films, 7 tablets, 8,9 and hydrogels 10 have been reported in the literature. Recently, attention has been focused on the development of ionic polysaccharide hydrogel beads for use as oral drug carriers. 11 Different ionic polysaccharide beads based on sodium alginate (SA), 12 chitosan, 13 and pectin 14 have been extensively developed and examined for the encapsulation of a wide range of drugs. 15,16 However, major limitations of these ionic beads are the small drug encapsulation capacity due to drug leaching through the pores and the fast degradation in alkaline pH media resulting in burst release of drugs. 17 To overcome the limitations of these ionic polysaccharide beads, the combination of ionic and natural polysaccharides has been proposed. 18,19 Most of the reported results using this approach are based ...

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Floating capsules containing alginate-based beads of salbutamol sulfate: In vitro–in vivo evaluations

Cited by 55 publications

References 30 publications

Mucoadhesive-floating zinc-pectinate–sterculia gum interpenetrating polymer network beads encapsulating ziprasidone HCl

Mucoadhesive-floating zinc-pectinate–sterculia gum interpenetrating polymer network beads encapsulating ziprasidone HCl

Floating-Bioadhesive Matrix Tablets of Hydralazine HCL Made of Cashew Gum and HPMC K4m

Formulation characterization and in vitro evaluation of acacia gum–calcium alginate beads for oral drug delivery systems

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