Flavoxate Hydrochloride in the Treatment of Detrusor Instability

Delaere, K.P.J.; Michiels, Hege; Debruyne, F. M. J.; Moonen, W.A.

doi:10.1159/000280154

Cited by 26 publications

(7 citation statements)

References 7 publications

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“…None of the available drugs has been shown to have a selective effect on the urinary bladder [25], Flavoxate has a papaverin-like 'direct ' smooth muscle relaxant effect, but the mechanism of action is still not clarified. The clinical effect of flavoxate in the treatment of overactive detrusor function is not well documented [46][47][48],…”

Section: Drugs Inhibiting Detrusor Contractilitymentioning

confidence: 99%

Clinical Pharmacology of the Lower Urinary Tract

Lose¹,

Andersen²

1986

Eur Urol

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Section: Drugs Inhibiting Detrusor Contractilitymentioning

confidence: 99%

Clinical Pharmacology of the Lower Urinary Tract

Lose¹,

Andersen²

1986

Eur Urol

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“…Flavoxate is reported to have local anaesthetic properties (Pedersen et al, 1973) which may contribute to its action in the relief of spasm caused by infection or mechanical irritation (Delaere et al, 1977). Local application of cocaine to the mucosa of isolated innervated guinea pig bladder blocks the contractile response to pelvic nerve stimulation (Bissada et al, 1979b).…”

Section: Mucosa Of Bladder and Urethramentioning

confidence: 99%

The lower urinary tract.

Robinson¹

1982

Brit J Clinical Pharma

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The bladder and urethra are concerned with the collection and storage of urine, the voiding of this urine at consciously chosen times once continence has been acquired and the ability to prevent leakage between these times. To achieve these functions the structure and response of the bladder and urethra must Figure 1 Innervation of bladder and urethra with diagrammatic representation of central nervous pathways (Fletcher & Bradley, 1978). Sympathetic pathways (----) synapse chiefly in the hypogastric plexus and parasympathetic (-.-.-.-) in the pelvic/vesical plexus. The striated sphincters are innervated by somatic ( ) nerves.lr-.

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“…A number of authors prefer flavoxate anticholinergics for the treatment of urge incontinence in view of its better benefit-risk ratio [8]; moreover, there is some evidence for therapeutic success in patients initially treated unsuccessfully with anticholinergics [9].…”

Section: Introductionmentioning

confidence: 99%

Using Flavoxate as Primary Medication for Patients Suffering from Urge Symptomatology

1999

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A drug utilization observation study collected data on a total of 1800 patients given flavoxate (Spasuret 200) over 2 weeks for urge incontinence. Efficacy and tolerance parameters were determined. A subgroup of 618 patients without urinary tract infections or benign prostatic hyperplasia were treated with flavoxate only. The subgroup (n = 618) showed a reduction of dysuria (37%), nocturia (53%), and both daytime (61%) and nighttime urge (69%). Bladder volume at first urge sensation increased by 55.1+/-58.8 ml (36%), which was comparable to data from the entire group (1800 patients). In 89.2% of all patients the residual urine volume was stable or decreased. Undesirable side effects occurred in 1.8% of cases. Both groups showed better results with flavoxate four times daily (800 mg), compared to three times daily (600 mg). Flavoxate is effective and well tolerated and causes no additional problems due to residual urine or side effects.

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Flavoxate Hydrochloride in the Treatment of Detrusor Instability

Cited by 26 publications

References 7 publications

Clinical Pharmacology of the Lower Urinary Tract

Clinical Pharmacology of the Lower Urinary Tract

The lower urinary tract.

Using Flavoxate as Primary Medication for Patients Suffering from Urge Symptomatology

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