Flavonoids in Inflammatory Bowel Disease: A Review

Vezza, Teresa; Rodríguez-Nogales, Alba; Algieri, Francesca; Utrilla, M. Pilar; Rodríguez-Cabezas, M. Elena; Gálvez, Júlio

doi:10.3390/nu8040211

Cited by 190 publications

(179 citation statements)

References 136 publications

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“…In addition, their criteria for bleeding were different from ours and they did not measure stool consistency and clinical activity of colitis. intestine (13).…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Honey and Spirulina Platensis on Acetic Acid-Induced Ulcerative Colitis in Rats

Rezaei

Eftekhari

Tanideh

et al. 2018

Iran Red Crescent Med J

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Background: Overproduction of reactive oxygen species (ROS) causes increased lipid peroxidation, decreased intestinal epithelial barrier integrity, and ultimately mucosal disruption and ulceration. Several studies have confirmed the antioxidant, antiinflammatory, and immunomodulatory properties of Spirulina Platensis (SP), edible blue -green algae, in various inflammatory diseases. In addition, natural honey, a source of phenolic and flavonoid compounds, is a powerful antioxidant, which can help prevent chronic oxidative stress and subsequent inflammation. Objectives: In this study, we examined and compared the protective effects of SP and honey on ulcerative colitis induced by acetic acid (AA) in rats. Methods: Forty male rats were allocated into five groups (N = 8) and received pretreatment for 32 consecutive days. The administrations were as follows: group 1 (control) and group 2 (AA-colitis group): normal saline, group 3: 1 ml honey/day, group 4: 1 ml honey/day plus 1 g/kg SP, and group 5: 1 g/kg SP. Colitis was induced on the 30th day in groups 2 to 5. On day 32, the clinical activity was determined and anesthetized animals were sacrificed. Serum interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α (TNF-α), glutathione peroxidase (GPx), reduced glutathione (GSH), total antioxidant capacity (TAC), superoxide dismutase (SOD), colonic tissues myeloperoxidase (MPO), prostaglandin E2 (PGE2), malondialdehyde (MDA), nitric oxide (NO), and colonic weight/length ratio were determined. In addition, histopathological changes of the colon were observed microscopically.

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“…In addition, their criteria for bleeding were different from ours and they did not measure stool consistency and clinical activity of colitis. intestine (13).…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Honey and Spirulina Platensis on Acetic Acid-Induced Ulcerative Colitis in Rats

Rezaei

Eftekhari

Tanideh

et al. 2018

Iran Red Crescent Med J

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“…Current dietary interventions to reduce intestine inflammation and thus, lessen the pain associated with such conditions include treatment with both macro- and micronutrients. For example, in rodent models of colitis and/or in vitro studies investigating anti-inflammatory therapeutics milk oligosaccharides, PUFAs, and polyphenolic compounds such as flavonoids are shown to significantly reduce intestinal inflammation (Lara-Villoslada, et al 2006; Vezza, et al 2016). Given this, it is a logic extension to use dietary approaches for protecting against obesity-associated intestinal inflammation.…”

Section: Nutritional Approaches For Suppression Of Obesity-associamentioning

confidence: 99%

Nutritional approaches for managing obesity-associated metabolic diseases

Botchlett

Woo

et al. 2017

Journal of Endocrinology

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Obesity is an ongoing pandemic and serves as a causal factor of a wide spectrum of metabolic diseases including diabetes, fatty liver disease, and cardiovascular disease. Much evidence has demonstrated that nutrient overload/overnutrition initiates or exacerbates inflammatory responses in tissues/organs involved in the regulation of systemic metabolic homeostasis. This obesity-associated inflammation is usually at a low-grade and viewed as metabolic inflammation. When it exists continuously, inflammation inappropriately alters metabolic pathways and impairs insulin signaling cascades in peripheral tissues/organs such as adipose tissue, the liver and skeletal muscle, resulting in local fat deposition and insulin resistance and systemic metabolic dysregulation. In addition, inflammatory mediators, e.g., proinflammatory cytokines, and excessive nutrients, e.g., glucose and fatty acids, act together to aggravate local insulin resistance and form a vicious cycle to further disturb local metabolic pathways and exacerbate systemic metabolic dysregulation. Owing to the critical role of nutrient metabolism in the control of the initiation and progression of inflammation and insulin resistance, nutritional approaches have been implicated as effective tools for managing obesity and obesity-associated metabolic diseases. Based on the mounting evidence generated from both basic and clinical research, nutritional approaches are commonly used for suppressing inflammation, improving insulin sensitivity, and/or decreasing fat deposition. Consequently, the combined effects are responsible for improvement of systemic insulin sensitivity and metabolic homeostasis.

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“…Flavonoids are found in berries, tea, cocoa, soybeans, grains, and plant leaves, are a class of organic polyphenolic compounds [2] . It is through various mechanisms including protection against oxidative stress, and preservation of epithelial barrier function and immunomodulatory properties that flavonoids are used in acute or chronic intestinal inflammation [3] . Dietary flavonoids (quercetin and morin) have marked effects on the fatty acid composition of blood plasma, liver, or breast muscle lipids in vitamin E-deficient chicks [4] .…”

Section: Introductionmentioning

confidence: 99%

Dut Yaprağından Elde Edilen Flavonoidler ile Candida Tropicalis’in Buzağılarda Performans ve Besin Sindirilebilirliği Üzerine Etkileri

Zhang¹,

Qu²,

Yan³

et al. 2017

Kafkas Univ Vet Fak Derg

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Flavonoids from mulberry leave (FML) are natural flavonoids, and Candida tropicalis (CT) is yeast like microbe. In this study, forty-eight male calves were selected with born weight (40.5±0.7 kg) and 20±2 days age, divided into 4 groups randomly. FML was supplemented in a dairy calf starter at 2 g/d per calf before weaning, or 4 g/d per calf after weaning (FML group), while CT was added in a dairy calf starter at 1 g/d per calf (CT group). Our results showed that FML could be used to enhance body weight (BW) of calves through enhancing apparent digestibility of ether extract (EE) of the diet, and increased the levels of serum growth hormone (GH) and insulin-like growth factors 1 (IGF-1) in calves after the age of 56 days. CT enhanced the BW of calves before weaning through increasing the apparent digestibility of neutral detergent fiber (NDF) of the diet, and elevated the apparent digestibility of EE of the diet of calves after weaning through increasing the level of serum IGF-1 in calves. Furthermore, the mixture of FML and CT plays a synergistic role in enhancing growth, improving feed intake and nutriment digestibility. In conclusion, FML and CT could be used as additives to increase growth and nutrient digestibility in calves. Keywords: Calves, Flavonoids from mulberry leave, Candida tropicalis, Nutriment digestibility, Hormone level Dut Yaprağından Elde Edilen Flavonoidler İle Candida tropicalis'in Buzağılarda Performans ve Besin Sindirilebilirliği Üzerine Etkileri ÖzetDut yaprağından elde edilen flavonoidler (FML) doğal flavonoidler olup Candida tropicalis (CT) de mantar benzeri mikroplardır. Bu çalışmada, doğumda 40.5±0.7 kg ağırlığa sahip 20±2 günlük kırk sekiz erkek buzağı kullanılarak rastgele 4 gruba ayrıldı. FML sütten kesme öncesi her bir buzağı için 2 g/d olarak buzağı başlangıç yemi içerisinde veya her bir buzağı için 4 g/d olarak sütten kesme sonrası (FML grup), CT ise her bir buzağı için 1 g/d olarak buzağı başlangıç yemi içerisinde (CT grup) verildi. Çalışma sonucunda FML'nin diyetin eter ekstraktının (EE) sindirilebilirliğini ve serum büyüme hormonu (GH) ve insülin benzeri büyüme faktörü 1 (IGF-1)'in seviyelerini belirgin bir şekilde arttırmak yoluyla 56 günlükten sonrasında buzağıların vücut ağırlığını (BW) geliştirmek amacıyla kullanılabileceği tespit edilmiştir. CT; buzağıların vücut ağırlığını sütten kesme öncesinde diyetteki nötr deterjan fiberin sindirilebilirliğini belirgin ölçüde geliştirdi ve serum IGF-1'in seviyesini yükseltmek suretiyle sütten kesme sonrasında diyetteki eter ekstraktının sindirilebilirliğini belirgin ölçüde artırdı. FML ve CT karışımı büyümeyi geliştirme, gıda tüketimini ve besin sindirilebilirliğini iyileştirmekte sinerjistik bir rol oynadı. Sonuç olarak, FML ve CT büyüme ve besin sindirilebilirliğini artırmak amacıyla buzağılarda bir katkı olarak kullanılabilir.

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Flavonoids in Inflammatory Bowel Disease: A Review

Cited by 190 publications

References 136 publications

Protective Effects of Honey and Spirulina Platensis on Acetic Acid-Induced Ulcerative Colitis in Rats

Protective Effects of Honey and Spirulina Platensis on Acetic Acid-Induced Ulcerative Colitis in Rats

Nutritional approaches for managing obesity-associated metabolic diseases

Dut Yaprağından Elde Edilen Flavonoidler ile Candida Tropicalis’in Buzağılarda Performans ve Besin Sindirilebilirliği Üzerine Etkileri

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