Flavonoids can replace α‐tocopherol as an antioxidant

Acker, F.A.A. van; Schouten, Olga; Haenen, Guido R.M.M.; Vijgh, W.J.F. van der; Bast, Aalt

doi:10.1016/s0014-5793(00)01517-9

Cited by 231 publications

(136 citation statements)

References 21 publications

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“…Reductions in GPx activity noted in the CsA treated rats in the present study are consistent with results obtained by others [3]. Flavonoids usually contain one or more aromatic hydroxyl groups in their moiety, which is responsible for their antioxidant activity [58]. Naringenin have already been pharmacologically evaluated as a potential antioxidant [50].…”

Section: Discussionsupporting

confidence: 92%

Therapeutic efficacy of naringin on cyclosporine (A) induced nephrotoxicity in rats: Involvement of hemeoxygenase-1

Chandramohan

Parameswari

2013

Pharmacological Reports

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Abstract:Background: Clinically, chronic nephrotoxicity may lead to renal functional impairment and progress to end stage renal failure. The renoprotective effect of a flavonoid naringin (NG) against cyclosporine A (CsA)-induced nephrotoxicity was investigated in this study. Methods: Nephrotoxicity was induced in male albino Wistar rats by injecting 25 mg/kg body weight of CsA for a period of 21 days. CsA-induced rats were also cotreated with 40 mg of NG/kg body weight, orally. Results: After the experimental period, the levels of lipid peroxides (TBARS) and hydroxyl radical (OH ) were found to be elevated, whereas the levels of SOD, catalase, glutathione, vitamin C, E and A were decreased in CsA-induced rats. NG co-treatment significantly decreased the levels of lipid peroxides and hydroxyl radicals and restored the levels of enzymic and non-enzymic antioxidants in renal tissues. Histological analysis revealed that CsA administration caused severe and widespread necrosis with dilatation of proximal tubules, vacuolization, tubular cell desquamation and intraluminal cast formation with massive infiltration of inflammatory cells. CsA-induced histopathological renal changes were minimal in animals which received NG treatment. The western blot and confocal microscopic expression of heme oxygenase-1 was restored by NG. In CsA-induced animals the expression was reduced compared to NG treated animals. Conclusions: The present study reveals that NG can act as effective renoprotective drug against CsA-induced toxicity.

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Section: Discussionsupporting

confidence: 92%

Therapeutic efficacy of naringin on cyclosporine (A) induced nephrotoxicity in rats: Involvement of hemeoxygenase-1

Chandramohan

Parameswari

2013

Pharmacological Reports

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“…Flavonoids are known to have powerful antioxidant properties, which are generally attributed to the presence of phenolic hydroxyl groups. The presence of one or more aromatic hydroxyl moiety is responsible for their antioxidant activity (van Acker et al 2000). Chemically, bikaverin is a polyketide with a tetracyclic benzoxanthone structure.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Bikaverin on H2O2-Induced Oxidative Stress Mediated Neuronal Damage in SH-SY5Y Cell Line

et al. 2014

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The generation of free radicals and oxidative stress has been linked to several neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease, and Amyotrophic lateral sclerosis. The use of free radical scavenging molecules for the reduction of intracellular reactive oxygen species is one of the strategies used in the clinical management of neurodegeneration. Fungal secondary metabolism is a rich source of novel molecules with potential bioactivity. In the current study, bikaverin was extracted from Fusarium oxysporum f. sp. lycopersici and its structural characterization was carried out. Further, we explored the protective effects of bikaverin on oxidative stress and its anti-apoptotic mechanism to attenuate H 2 O 2 -induced neurotoxicity using human neuroblastoma SH-SY5Y cells. Our results elucidate that pretreatment of neurons with bikaverin attenuates the mitochondrial and plasma membrane damage induced by 100 lM H 2 O 2 to 82 and 26 % as evidenced by MTT and LDH assays. H 2 O 2 induced depletion of antioxidant enzyme status was also replenished by bikaverin which was confirmed by Realtime Quantitative PCR analysis of SOD and CAT genes. Bikaverin pretreatment efficiently potentiated the H 2 O 2 -induced neuronal markers, such as BDNF, TH, and AADC expression, which orchestrate the neuronal damage of the cell. The H 2 O 2 -induced damage to cells, nuclear, and mitochondrial integrity was also restored by bikaverin. Bikaverin could be developed as a preventive agent against neurodegeneration and as an alternative to some of the toxic synthetic antioxidants.

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“…Feeding of orange juice, grapefruit juice or pure flavanones has been shown to inhibit several types of chemically induced carcinogenesis in laboratory animals (So et al, 1996Yang et al, 1997). The mechanisms of action are unclear, but hesperetin and=or naringenin have been reported to inhibit estrone sulfatase (Huang et al, 1997) and cytochrome P-450 isoenzymes (Ghosal et al, 1996), to bind to estrogen receptors (Kuiper et al, 1998;Hunter et al, 1999) and to sex hormonebinding globulin (Dechaud et al, 1999), and to act as antioxidants (van Acker et al, 2000;Fuhrman & Aviram, 2001). Furthermore, flavanones have been shown to affect cholesterol metabolism in rats (Bok et al, 1999) and in HepG2 cells (Borradaile et al, 1999), and in a recent study, ingestion of orange juice increased HDL cholesterol levels in hypercholesterolemic human subjects (Kurowska et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables

et al. 2002

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Objectives: To determine the fasting plasma concentrations of quercetin, hesperetin and naringenin in human subjects consuming their habitual diets, and diets either high or low in fruit and vegetables. To investigate whether plasma concentrations of flavanones can serve as biomarkers of their intake. Design: This was a cross-over, strictly controlled dietary intervention consisting of a 2 week baseline period, and two 5 week dietary periods with a 3 week wash-out period in between. The low-vegetable diet contained few fruit and vegetables and no citrus fruit. The high-vegetable diet provided various fruits and vegetables daily including on average one glass of orange juice, one-half orange and one-half mandarin. Subjects: Thirty-seven healthy females. Results: The high-vegetable diet provided 132 mg of hesperetin and 29 mg of naringenin. The low-vegetable diet contained no flavanones. The mean plasma hesperetin concentration increased from 12.2 nmol=l after the low-vegetable diet to 325 nmol=l after the high-vegetable diet. The respective increase for naringenin was from < 73.5 nmol=l for all subjects to a mean value of 112.9 nmol=l. The mean plasma quercetin concentration was 52 nmol=l after the baseline period, during which habitual diets were consumed, and it did not change significantly during the intervention. Interindividual variation in the plasma levels of hesperetin and naringenin was marked and, after the baseline and wash-out periods, and the low-vegetable diet, a majority of the samples had plasma flavanone levels below the limit of detection. After the high-vegetable diet, hesperetin and naringenin were detectable in 54 and 22% of all samples. Quercetin was detectable in nearly all samples after all study periods. Conclusion: Hesperetin, naringenin and quercetin are bioavailable from the diet, but the plasma concentrations of hesperetin and naringenin are poor biomarkers of intake.

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Flavonoids can replace α‐tocopherol as an antioxidant

Abstract: Endogenous antioxidants such as the lipid-soluble vitamin E protect the cell membranes from oxidative damage.

Cited by 231 publications

References 21 publications

Therapeutic efficacy of naringin on cyclosporine (A) induced nephrotoxicity in rats: Involvement of hemeoxygenase-1

Therapeutic efficacy of naringin on cyclosporine (A) induced nephrotoxicity in rats: Involvement of hemeoxygenase-1

Neuroprotective Effects of Bikaverin on H2O2-Induced Oxidative Stress Mediated Neuronal Damage in SH-SY5Y Cell Line

Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables

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